Biophysical Society 60th Annual Meeting

2166-Pos Board B310 CLASS I ANTI-ARRHYTHMICS DIFFERENTIALLY REGULATE CARDIAC SODIUM CHANNEL VOLTAGE-SENSING DOMAINS. Angela R. Schubert , Wandi Zhu, Jonathan R. Silva 2167-Pos Board B311 BIOPHYSICAL CHARACTERIZATION OF TWO NAV1.4 MUTATIONS IDENTI- FIED IN PATIENTS WITH COLD-INDUCED MYOTONIA AND PERIODIC PARALYSIS. Hugo Poulin, Pascal Gosselin-Badaroudine, Karima Habbout, Savine Vicart, Damien Syternberg, Serena Giuliano, Sophie Nicole, Said Bendahhou, Mohamed Chahine 2168-Pos Board B312 MODELING ION CHANNEL KINETICS WITH PARAMETER CON- STRAINTS. Cynthia B. Lombardo , Marco A. Navarro, Autoosa Salari, Lorin DEFINING THE PROTEIN:PROTEIN INTERACTION INTERFACE OF FGF14:NAV1.6 COMPLEX. Aditya K. Singh, Syed R. Ali , Fernanda Laezza 2170-Pos Board B314 ACTIVATION DYNAMICS OF SODIUM ION CHANNEL. Matthew Harrigan , Vijay Pande Voltage-gated Ca Channels (Boards B315 - B341) 2171-Pos Board B315 SWITCHABLE CARDIAC L TYPE CA 2+ CHANNEL TRANSCRIPT BY MINER- ALOCORTICOID PATHWAY. Thassio Mesquita, Gaelle Auguste, Jessica Sabourin, Gema Ruiz Hurtado, Valérie Rouffiac, Florian Le-Billan, Jérôme Fagart, Florence Lefebvre, Say Viengchareun, Eric Morel, Ana Maria Gomez, Marc Lombès, Jean Pierre Benitah 2172-Pos Board B316 TOWARD A NEW THERAPEUTIC STRATEGY IN THE TREATMENT OF TIMOTHY SYNDROME.  Ivy E. Dick , Rosy Joshi-Mukherjee, Wanjun Yang, Worawan B. Limpitikul, David T. Yue 2173-Pos Board B317 FUNCTIONAL RESCUE OF CALMODULINOPATHY IPSC-DERIVED CARDIO- MYOCYTES -- A FORAY INTO PERSONALIZED MEDICINE. Worawan B. Limpitikul , Pattraranee Limphong, Ivy E. Dick, Myoung Hyun Choi, Wanjun Yang, Jennifer Babich, David J. Tester, Michael J. Ackerman, Gordon F. Tomaselli, David T. Yue 2174-Pos Board B318 TOWARDS A STRUCTURAL PERSPECTIVE OF CALCIUM REGULATION OF L-TYPE CALCIUM CHANNELS. Rahul Banerjee , Manu Ben-Johny, Ivy Ellen Dick, David Tuckchow Yue 2175-Pos Board B319 BLOCKING OF T-TYPE CALCIUM CHANNELS BY TTA-A2 REVEALS A CON- SERVATIVE BINDING SITE FOR STATE-DEPENDENT ANTAGONISTS. Eduardo Chavez-Colorado, Zazil Herrera-Carrillo, Juan C. Gomora 2176-Pos Board B320 FUNCTIONAL AND MOLECULAR INTERACTION OF PHENYLALKYLAMINES AND DIHYDROPYRIDINES WITH THE MODEL CALCIUM CHANNEL CAV- AB. Tamer M. Gamal El-Din , Teresa M. Swanson, Lin Tang, Ning Zheng, William A. Catterall 2177-Pos Board B321 NITRIC OXIDE INHIBITS HIGH VOLTAGE-ACTIVATED CALCIUM CHANNELS THROUGH S-NITROSYLATION. Menghua Zhou , Alexis Bavencoffe, Hui-Lin Pan S. Milescu 2169-Pos Board B313 CID TRAVEL AWARDEE

2154-Pos Board B298 A SYSTEMATIZED APPROACH TO INVESTIGATE CA 2+ SYNCHRONIZATION IN IPSC-DERIVED CARDIOMYOCYTE NETWORKS. Aled R. Jones, David H. Edwards, Michael J. Cummins, Alan J. Williams, Christopher H. George 2155-Pos Board B299 NUCLEATION OF CALCIUMWAVES IN CARDIAC CELLS: THE ROLE OF NETWORK CONNECTIVITY. Gonzalo Hernandez-Hernandez , Yohannes Shiferaw, Enric Alvarez-Lacalle 2156-Pos Board B300 CATECHOLAMINERGIC STIMULATION OF NEURONAL NA + CHAN- NELS ACCOUNTS FOR TRIGGERED ARRHYTHMIA MECHANISM IN CPVT. Przemysław B. Radwański , Hsiang-Ting Ho, Bin Liu, Andriy Belevych, Antonis Armoundas, Wolfgang Dillmann, Bjorn Knollmann, Peter Mohler, Thomas Hund, Sándor Györke 2157-Pos Board B301 EFFECTS OF BETA-ADRENERGIC STIMULATION ON RAT FAILING CARDIO- MYOCYTES. Claudia Crocini , Raffaele Coppini, Cecilia Ferrantini, Ping Yan, Leslie M. Loew, Elisabetta Cerbai, Corrado Poggesi, Francesco S. Pavone, Leonardo Sacconi 2158-Pos Board B302 CONDITIONS THAT PROMOTE GOLGI CA 2+ RELEASE FACILITATE TRAFFICK- ING OF VEGFR-1 TO THE SURFACE MEMBRANE IN RAT VENTRICULAR MYOCYTES. Hannah M. Kirton , Zhaokang Yang, Derek S. Steele 2159-Pos Board B303 PROPENSITY AND SEVERITY OF CARDIAC ALTERNANS IS ENHANCED IN HEART FAILURE. Giedrius Kanaporis , Lothar A. Blatter 2160-Pos Board B304 NOVEL CALMODULIN MUTATION (CALM3-A103V) ASSOCIATED WITH CPVT SYNDROME ACTIVATES ARRHYTHMOGENIC CA WAVES AND SPARKS. Nieves Gomez-Hurtado , Dmytro O. Kryshtal, Christopher N. Johnson, Walter J. Chazin, Nicole J. Boczek, Melissa L. Will, David J. Tester, Michael J. Ackerman, Bjorn C. Knollmann Voltage-gated Na Channels II (Boards B305 - B314) 2161-Pos Board B305 EDUCATION TRAVEL AWARDEE POINT-MUTATIONS IN SKELETAL MUSCLE VOLTAGE-GATED SODIUM CHANNELS CONFER RESISTANCE TO TETRODOTOXIN: BUT AT A COST? Robert E. del Carlo , Normand Leblanc, Edmund D. Brodie, Jr., Chis R. Feldman 2162-Pos Board B306 INHIBITION OF A VOLTAGE-GATED SODIUM CHANNEL BY PROPOFOL INVOLVES MODULATION OF SLOW INACTIVATION. Elaine Yang , Vincenzo Carnevale, Manuel Covarrubias 2163-Pos Board B307 A MODIFIED NEURONAL CELL LINE FOR HIGH THROUGHPUT ANALYSIS OF VOLTAGE-GATED SODIUM CHANNELS. Carlos G. Vanoye , Tatiana V. Abramova, Jean-Marc L. DeKeyser, Alfred L. George 2164-Pos Board B308 DIII OF VOLTAGE-GATED NA + CHANNELS INTERACTS WITH INACTIVATION IN THE TIME DOMAIN OF INTERMEDIATE INACTIVATION. Eric J. Hsu , Wandi Zhu, Zoltan Varga, Angela R. Schubert, Jonathan R. Silva 2165-Pos Board B309 MAPPING THE NAV1.7 CHANNEL INTERACTION WITH THE CONOTOXIN KIIIA.  Ian H. Kimball , Phuong T. Nguyen, Jon T. Sack, Vladimir Yarov-Yarovoy

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