Biophysical Society 60th Annual Meeting

3033-Pos Board B410 β-MYHC MUTATIONS LINKED TO EARLY-ONSET HCM AND DCM SHOW DIFFERENCES IN PRE-STEADY AND STEADY STATE KINETIC PARAM- ETERS. Carlos D. Vera Velazquez , Jonathan Walklate, Michael A. Geeves, Leslie A. Leinwand 3034-Pos Board B411 ARACHIDONIC ACID DIRECTLY BINDS AND ACTIVATES BETA-CARDIAC MYOSIN IN THE REGULATED CARDIAC ACTOMYOSIN COMPLEX. Manuel H. Taft , Giulia Falorsi, Michael B. Radke, Salma Pathan-Chhatbar, Nikolas Hundt, Claudia Thiel, Mirco Müller, Vincenzo Lombardi, Dietmar J. Board B412 MODELLING OF DOUBLE HIT MUTATIONS IN THORACIC AORTIC ANEU- RYSM DISEASE THAT HAVE VARIABLE IMPACT ON PHENOTYPE. Brett D. Hambly , Elizabeth Robertson, Stefanie S. Portelli, Yaxin Lu, Murat Kekic, Richmond Jeremy 3036-Pos Board B413 ELECTROSTATICS OF ACTOMYOSIN INTERFACE AND THE RATE OF RIGOR BINDING.  Jinghua Ge , Bhavana Ambil, Furong Huang, Yuri E. Nesmelov 3037-Pos Board B414 MYOSIN II HEAD INTERACTION IN PRIMITIVE SPECIES. Kyounghwan Lee, Shixin Yang, Xiong Liu, Edward D. Korn, Floyd Sarsoza, Sanford I. Bern- stein, Luther Pollard, Matthew J. Lord, Kathleen M. Trybus, Roger Craig 3038-Pos Board B415 EDUCATION TRAVEL AWARDEE CHARACTERIZATION OF A UNIQUE MYOSIN IIIA DEAFNESS MUTATION WHICH ENHANCES ACTIN-SLIDING VELOCITY BUT ABOLISHES FILOPODIA TIP LOCALIZATION. Manmeet H. Raval , Lina Jamis, William Unrath, Omar A. Quintero, M’hamed Grati, Jasmine Crenshaw, Xue Zhong Liu, Christopher M. Yengo 3039-Pos Board B416 LARGE VESICLE MOVES IN ROLLING MANNER BY MYOSIN 5C ALONG AC- TIN TRACKS.  Justin J. Raupp , Alexander Pattyn, Laura K. Gunther, Xuequn Chen, Takeshi Sakamoto 3040-Pos Board B417 MYOSIN 19 IS AN OUTER MITOCHONDRIAL MEMBRANE MOTOR AND EFFECTOR OF STARVATION INDUCED FILOPODIA WITH UNIQUE KINETIC FEATURES. Arnon Henn , Boris Shneyer, Marko Usaj 3041-Pos Board B418 COMPARING THE MOTILITY OF MYOSIN X WITH PARALLEL AND ANTI- PARALLEL DIMERIZATION DOMAINS. Matthew A. Caporizzo , Claire E. Fishman, Osamu Sato, Mitsuo Ikebe, Yale E. Goldman 3042-Pos Board B419 DYNAMIC ACTIN NETWORKS UTILIZED TO SUPPORT SIMULTANEOUS PRO- CESSIVE MOTILITY OF TWO DIFFERENT MYOSIN MOTOR CLASSES. Alicja Santos , Ronald S. Rock 3043-Pos Board B420 EDUCATION TRAVEL AWARDEE FLUORESCENCE INTERFERENCE CONTRAST MICROSCOPY (FLIC) - A NEW TOOL TO STUDY THE COLLECTIVE MOTOR DYNAMICS. Agata K. Krenc , Jagoda Rokicka, Ronald S. Rock Cytoskeletal Assemblies and Dynamics (Boards B421 - B437) 3044-Pos Board B421 MEASURING THE ON-RATE OF MEMBRANE-CYTOSKELETON BONDS AT THE NEAR-EQUILIBRIUM REGION. Vivek Rajasekharan , Varun K. A. Sreenivasan, Jeffrey N. Myers, Fred A. Pereira, Brenda Farrell Manstein 3035-Pos

3020-Pos Board B397 THE CYCLIC AMP SIGNALING PATHWAY AND DIRECT PKA PHOSPHORYLA- TION REGULATE POLYCYSTIN-2 (TRPP2) CHANNEL FUNCTION. María del Rocío Cantero , Irina F. Velázquez, Andrew J. Streets, Albert C.M. Ong, Horacio F. Cantiello 3021-Pos Board B398 REGULATION OF POLYCYSTIN-2 TRPP2 ASSOCIATED CATION CURRENTS IN THE RENAL EPITHELIAL CELL LINE LLC-PK1 BY THE CALCIUM-SENSING RE- CEPTOR. Xiao Qing Dai, Paula L. Perez , Mariano Smoler, María del Rocío Cantero, Horacio F. Cantiello 3022-Pos Board B399 FURTHER EVIDENCE OF AN ALTERNATIVE ION PERMEATION PATHWAY IN THE NOCICEPTOR TRPM3. Katharina Held , Annelies Janssens, Thomas Voets, Joris Vriens 3023-Pos Board B400 TRPM3 EXHIBITS SLIGHT TEMPERATURE SENSITIVITY IN THE PLANAR LIPID BILAYER SYSTEM AND REQUIRES THE PRESENCE OF PIP 2 . Lusine Demirkhanyan , Kunitoshi Uchida, Swapna Asuthkar, Alejandro Cohen, Makoto Tominaga, Eleonora Zakharian 3024-Pos Board B401 ROLE OF THE KINASE DOMAIN IN TRPM7 CHANNEL ACTIVITY AND FUNC- TION. Ceredwyn E. Hill , Mustafa D. Ahmadzai 3025-Pos Board B402 TESTOSTERONE IS A HIGHLY POTENT AND SPECIFIC AGONIST OF TRPM8. Zahir Hussain, Lusine Demirkhanyan, Swapna Asuthkar, Eleonora Board B403 UBIQUITIN-MEDIATED TRPM8 PROTEIN DEGRADATION IN THE PATHO- GENESIS OF PROSTATE CANCER. Swapna Asuthkar , Alejandro Cohen, Lusine Demirkhanyan, Eleonora Zakharian 3027-Pos Board B404 COMPETITIVE PIRT AND PI(4,5)P2 INTERACTIONS MODULATE TRPM8. Nicholas J. Sisco, Parthasarathi Rath, Wade D. Van Horn 3028-Pos Board B405 IMPLICATIONS OF HUMAN TRPM8 CHANNEL GATING FROM SENSING DOMAIN AND MENTHOL BINDING STUDIES. Parthasarathi Rath 3029-Pos Board B406 BIOPHYSICAL CHARACTERIZATION OF HUMAN TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8) ION CHANNEL MODULATION BY PHOSPHOINOSITIDE REGULATOR OF TRP (PIRT).  Jacob K. Hilton , Nicholas J. Sisco, Parthasarathi Rath, Wade D. Van Horn 3030-Pos Board B407 TARGETING SEQUENCE AND FUNCTION-DEPENDENCE OF SUBCELLULAR LOCALIZATION OF TRANSIENT RECEPTOR POTENTIAL MUCOLIPIN CHAN- NELS.  Jian Xiong , Xinghua Feng, Michael X. Zhu Myosins (Boards B408 - B420) 3031-Pos Board B408 STRUCTURAL COORDINATION OF THE MYOSIN POWERSTROKE.  Joseph Muretta , John Rohde, David D. Thomas 3032-Pos Board B409 MECHANISM OF COOPERATIVE FORCE GENERATIONS BETWEEN SKEL- ETAL MYOSINS. Motoshi Kaya , Yoshiaki Tani, Takumi Washio, Toshiaki Hisada, Hideo Higuchi Zakharian 3026-Pos

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