Biophysical Society 60th Annual Meeting

3045-Pos Board B422 INTERNATIONAL TRAVEL AWARDEE DYNAMIC INSTABILITY EMERGES FROMMICROMECHANICS AND CHEMI- CAL KINETICS OF MICROTUBULE PROTOFILAMENTS.  Ishutesh Jain , Ranjith Padinhateeri 3046-Pos Board B423 INTERNATIONAL TRAVEL AWARDEE EFFECT OF BRANCHING ON FORCE-VELOCITY CURVES AND LENGTH FLUCTUATIONS OF ACTIN NETWORKS. Deepak K. Hansda , Shamik Sen, Ranjith Padinhateeri 3047-Pos Board B424 GLASSY DYNAMICS OF PASSIVE AND ACTIVE NETWORK MATERIALS: A MICROSCOPIC THEORY. Shenshen Wang , Peter Wolynes 3048-Pos Board B425 BOUNDARY EFFECTS ON ACTIVE ACTIN GELS. Felix Keber , Andreas Bausch 3049-Pos Board B426 FROM NANOSCALE TO MESOSCALE: INTEGRATING ADVANCED MICROS- COPY TECHNIQUES TO REVEAL THE ULTRASTRUCTURE AND COORDINAT- ED DYNAMICS OF MECHANOSENSORY PODOSOMES. Koen van den Dries, Marjolein BMMeddens, Elvis Pandzic, Ben Joosten, Johan A. Slotman, Leila Nahidiazar, Kees Jalink, Adriaan B. Houtsmuller, Paul W. Wisemann, Alessandra Cambi 3050-Pos Board B427 STRUCTURE AND DYNAMICS OF FILOPODIA STUDIED BY ELECTRON CRYO- TOMOGRAPHY AND SINGLE MOLECULE FLUORESCENCE IMAGING.  Andrew Howe, James Streetley, Michelle Peckham, Peter B. Rosenthal, Justin E. Molloy 3051-Pos Board B428 ACTIN FILAMENTS BUNDLING MECHANISMS BY FASCIN IN FILOPODIA WERE REVEALED WITH CRYO-ET. Shinji Aramaki , Kouta Mayanagi, Kazuhiro Aoyama, Takuo Yasunaga 3052-Pos Board B429 SUBSTRATE REGULATION OF CYTOSKELETAL ORDER AND BEATING STRAIN DYNAMICS OF CARDIOMYOCYTES. Kinjal Dasbiswas, Ohad Cohen, Sam Safran 3053-Pos Board B430 A MISSENSE MUTATION IN THE OBSCURIN GENE LEADS TO HYPERTRO- PHIC CARDIOMYOPATHY DUE TO DEREGULATED CALCIUM CYCLING. Li- Yen R. Hu, Maegen Ackermann, Peter Hecker, Benjamin Prosser, Brendan King, Kelly O’Connell, Larry Asico, Pedro Jose, Nathan Wright, Jonathan Lederer, Aikaterini Kontrogianni-Konstantopoulos 3054-Pos Board B431 TWO ISOFORMS OF MYOSIN-II ACCOUNT FOR THE TENSION OF THE FIS- SION YEAST CYTOKINETIC RING. Shuyuan Wang , Harvey F. Chin, Erdem Karatekin, Thomas D. Pollard, Ben O’Shaughnessy 3055-Pos Board B432 FULL T-CELL ACTIVATION BUT NOT EARLY SIGNALING REQUIRES ACTIN REMODELING. Marco Fritzsche , Christian Eggeling 3056-Pos Board B433 3-D TOPOLOGICAL ARRANGEMENT OF CYTOSKELETON MODULATED BY ENVIRONMENTAL MECHANICS. Chiao-Yu Tseng , Emilio Sanchez, Chin-Lin Guo 3057-Pos Board B434 STORAGE AND ABRUPT RELEASE OF ELASTIC ENERGY IN THE MICRO- TUBULE-EG5 NETWORK. Takayuki Torisawa, Daisuke Taniguchi, Shuji Ishihara, Kazuhiro Oiwa

3058-Pos Board B435 QUANTIFYING THE EFFECT OF ELECTRIC FIELDS IN THE FREQUENCY RANGE OF 100-500 KHZ ON MITOTIC SPINDLE STRUCTURES. Zeev Bom- zon , Cornelia Wenger, Moshe Giladi, Noa Urman, Rosa S. Schneiderman, Tali Voloshin Sela, Ya’ara Porat, Mijal Munster, Roni Blat, shay sherbo, Uri Weinberg, Eilon Kirson, Pedro C. Miranda, YoramWasserman, Yoram Palti 3059-Pos Board B436 BRIGHTNESS CHARACTERIZATION OF SUN1 AND SUN2 BY Z-SCAN FLUORESCENCE FLUCTUATION SPECTROSCOPY. Cosmo A. Saunders, Jared Hennen, Elizabeth M. Smith, Joachim D. Mueller, GW Gant Luxton 3060-Pos Board B437 DYNAMIC FORCE PATTERNS PROMOTE COLLECTIVE CELL MIGRATION.  Teresa Zulueta-Coarasa , Rodrigo Fernandez-Gonzalez Cell Mechanics, Mechanosensing, and Motility III (Boards B438 - B463) 3061-Pos Board B438 THE VINCULIN D1 DOMAIN STABILIZES αE-CATENIN IN A STRONG ACTIN BINDING STATE. Nicolas A. Bax 3062-Pos Board B439 MECHANOSENSITIVITY OF ACTIN TURNOVER ALLOWS CELLS TO MAIN- TAIN HOMEOSTASIS AGAINST MYOSIN-II CONTRACTILE FLUCTUATIONS IN THE CYTOSKELETON. Shuyuan Wang, Sathish Thiyagarajan , Mark A. Smith, Elizabeth Blankman, Laura M. Chapin, Mary C. Beckerle, Ben O’Shaughnessy 3063-Pos Board B440 MODELING MECHANICALLY-INDUCED GROWTH CONE ADVANCE RE- VEALS THE IMPORTANCE OF MICROMETER-SCALE ELASTIC ADHESION STRUCTURES IN RIGIDITY SENSING. Ahmad I M Athamneh , Rodolfo Amezcua, Arvind Raman, Daniel M. Suter 3064-Pos Board B441 BINDING FORCES OF SINGLE αMβ2 INTEGRIN-FIBRINOGEN INTERAC- TIONS ON LIVING CELLS. Wayne B. Christenson 3065-Pos Board B442 THE MECHANICAL PROPERTIES OF TALIN ROD DOMAIN. Mingxi Yao , Benjamin T. Goult, Michael P. Sheetz, Jie Yan 3066-Pos Board B443 FRUSTRATED PHAGOCYTIC SPREADING DYNAMICS END IN DISTINCT NON-MUSCLE MYOSIN II DEPENDENT CONTRACTION. Daniel T. Kovari , Wenbin Wei, Jan-Simon Toro, Ruth E. Fogg, Karen Porter, Jennifer E. Curtis 3067-Pos Board B444 ROLE OF TOPOGRAPHIC CUES ON CANCER CELL PROLIFERATION. Parthiv Kant Chaudhuri 3068-Pos Board B445 CELL MECHANICAL PROPERTIES AND CANCER METASTASIS: EFFECTS OF CANCER DRUGS AND RADIOTHERAPY. Sruti V. Prathivadhi-Bhayankaram, Carolyn E. Taylor, Jianhao Ning, Michael Nichols, Andrew E. Ekpenyong 3069-Pos Board B446 EVALUATING BREAST CANCER CELL MORPHOLOGY AS A PREDICTOR OF INVASIVE CAPACITY. Michelle J. Ziperstein , Asja Guzman, Laura J. Board B447 THE ROLE OF HETEROGENEITY IN CANCER CELL MIGRATION. Christoph Mark , Claus Metzner, Julian Steinwachs, Lena Lautscham, Ben Fabry 3071-Pos Board B448 MECHANICAL INDUCTION OF THE TUMORIGENIC β-CATENIN PATHWAY BY TUMOUR GROWTH PRESSURE IN VIVO. Emmanuel Farge Kaufman 3070-Pos

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