Biophysical Society 60th Annual Meeting

290-Pos Board B70 UNDERSTANDING CONFORMATIONAL CHANGES IN PERIPLASMIC BINDING PROTEINS. Nahren M. Mascarenhas, Shachi Gosavi 291-Pos Board B71 GENERALIZED ALLOSTERY IN THROMBIN.  Jiajie Xiao , Freddie R. Salsbury Jr Membrane Protein Structure and Folding I (Boards B72 - B102) 292-Pos Board B72 THE MODEL STRUCTURES OF C5A RECEPTOR (C5AR): INSIGHTS INTO AGONISM, INVERSE AGONISM AND ANTAGONISM. Soumendra Rana 293-Pos Board B73 DESIGN PRINCIPLES OF MEMBRANE PROTEIN STRUCTURES. Diane Nguyen, Vladimir Yarov-Yarovoy 294-Pos Board B74 DUAL TOPOLOGY GENERATION OF EMRE. Nicholas Woodall , Ying Yin, James Bowie 295-Pos Board B75 OPENING ION-TRANSFER PATHS OF CHANNELRHODOPSIN. Christian Spakowski , Joachim Heberle, Ana-Nicoleta Bondar 296-Pos Board B76 IMPROVED 3D STRUCTURE PREDICTION OF BETA-BARREL MEMBRANE PROTEINS BY USING EVOLUTIONARY COUPLING CONSTRAINTS, REDUCED STATE SPACE AND AN EMPIRICAL POTENTIAL FUNCTION. Wei Tian, Jie Liang, Hammad Naveed 297-Pos Board B77 COARSE-GRAINED MODELING OF MEMBRANE PROTEIN INTEGRATION VIA THE SEC TRANSLOCON. Michiel J.M. Niesen , Connie Y. Wang, Thomas F. Miller III 298-Pos Board B78 DETERMINANTS OF MULTISPANNING MEMBRANE PROTEIN INTEGRA- TION MEDIATED BY THE SEC TRANSLOCON. Reid C. Van Lehn , Bin Zhang, Thomas F. Miller III 299-Pos Board B79 HETEROGENEITY OF THE HYDROPHOBIC CORE OF A MEMBRANE PRO- TEIN COMPLEX. Satarupa Bhaduri , Stanislav D. Zakharov, S Saif Hasan, Valentyn Stadnytskyi, Łukasz Bujnowicz, Marcin Sarewicz, Artur Osyczka 300-Pos Board B80 PROBING CONFORMATIONAL EQUILIBRIA IN FLEXIBLE RECOGNITION BY MOLECULAR DYNAMICS AND EPR.  Jennifer M. Hays , Marissa Kieber, Tsega Solomon, Linda Columbus, Peter M. Kasson 301-Pos Board B81 COMPUTATIONAL STUDY OF ANTHRACYCLINE INTERACTIONS WITH MEMBRANE-EMBEDDED P-GLYCOPROTEIN. Eric K. Wong , J. Alfredo Freites, Douglas J. Tobias 302-Pos Board B82 NMR RESTRAINED PROTEIN STRUCTURE CALCULATIONS IN IMPLICIT WATER/MEMBRANE ENVIRONMENTS. Ye Tian , Charles Schwieters, Stanley Opella, Francesca Marassi 303-Pos Board B83 PREDICTING THE ROLE OF A SINGLE AMINO ACIDS IN THE DIMERIZATION OF TRANSMEMBRANE HELICES. Yao Xiao , Mark Teese, Dieter Langosch

275-Pos Board B55 SIALIC ACID INDUCED CONFORMATIONAL ENSEMBLE SHIFTS IN THE HEMAGGLUTININ-NEURAMINIDASE PROTEIN OF THE NEWCASTLE DISEASE VIRUS. Nalvi D. Duro , Priyanka Dutta, Sameer Varma 276-Pos Board B56 MOLECULAR INSIGHTS FOR THE ROLE OF KEY RESIDUES OF CALRETICU- LIN IN ITS BINDING ACTIVITIES. Hongyi Yang, Joanne E. Murphy-Ullrich, Yuhua Song 277-Pos Board B57 UNIQUE FLEXIBILITY PATTERNS OF PDB ENTRIES. Monique M. Tirion 278-Pos Board B58 LOSS IN ALLOSTERIC REGULATIONS THROUGH STRUCTURAL DYNAMICS LEAD TO DISEASE. Avishek Kumar , Tyler J. Glembo, Banu Ozkan 279-Pos Board B59 UNIVERSALITY OF VIBRATIONAL SPECTRA OF GLOBULAR PRO- TEINS. Hyuntae Na, Guang Song, Daniel ben-Avraham 280-Pos Board B60 THE DEGENERACY OF PROTEIN NORMAL MODES. Hyuntae Na , Guang Song 281-Pos Board B61 STATISTICAL PHYSICS OF THE CAUSALITY AND ENERGETICS IN ALLOSTERIC COMMUNICATION. Enrico Guarnera , Igor N. Berezovsky 282-Pos Board B62 INTERNATIONAL TRAVEL AWARDEE SPECTRUS: A DIMENSIONALITY REDUCTION APPROACH FOR IDENTIFY- ING DYNAMICAL DOMAINS IN PROTEIN COMPLEXES FROM LIMITED STRUCTURAL DATASETS. Luca Ponzoni , Guido Polles, Vincenzo Carnevale, Cristian Micheletti 283-Pos Board B63 MODE LOCALIZATION IN THE COOPERATIVE DYNAMICS OF PROTEIN RECOGNITION.  Jeremy T. Copperman , Marina G. Guenza 284-Pos Board B64 TUNING ALLOSTERY IN RANDOM SPRING NETWORKS.  Jason W. Rocks , Nidhi Pashine, Irmgard Bischofberger, Carl P. Goodruch, Sidney R. Nagel, Andrea J. Liu 285-Pos Board B65 REVEALING THE MECHANISM FOR CONFORMATIONAL CHANGES FROM STRUCTURALLY RICH ENSEMBLES. Laura Orellana , Ozge Yoluk, Modesto Orozco, Erik Lindahl 286-Pos Board B66 FOLDING RATE AND TRANSITION PATH TIME OF A SINGLE-MOLECULE PROTEIN. Amar Nath Gupta 287-Pos Board B67 FASTER BINDING FREE-ENERGY LANDSCAPE CALCULATION BY VIRTUAL- STATE COUPLED ADAPTIVE UMBRELLA SAMPLING. Bhaskar Dasgupta , Higo Junichi, Haruki Nakamura 288-Pos Board B68 EDUCATION TRAVEL AWARDEE DYNAMICS OF AGGREGATING MUTANTS OF THE P53 DNA BINDING DOMAIN REVEAL A NOVEL “DRUGGABLE” POCKET. Mohan R. Pradhan , Zahra Ouray, Srinivasaraghavan Kannan, David P. Lane, Chandra S. Verma 289-Pos Board B69 CALCULATING MULTI-BODY COOPERATIVITY PARAMETERS FOR CALCIUM BINDING TO CALMODULIN THROUGH COARSE-GRAINED SIMULATIONS. Prithviraj Nandigrami , John J. Portman .

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