Biophysical Society 60th Annual Meeting

Voltage-gated K Channels and Mechanisms of Voltage Sensing and Gating I (Boards B302 - B331) 522-Pos Board B302 WATER TRANSPORT ACROSS THE VOLTAGE SENSOR OF SHAKER K-CHAN- NELS DURING ACTIVATION.  Ignacio Diaz-Franulic , David Naranjo 523-Pos Board B303 HYDRATION AND THE ELECTRIC FIELD IN THE VOLTAGE SENSING DOMAIN OF THE KV1.2 CHANNEL: QUANTUM CALCULATIONS SHOW S4 DOESN’T MOVE, BUT WATER AND PROTONS MOVE. Alisher M. Kariev, Michael E. Green 524-Pos Board B304 WATER AND A PROTON SHIFT BETWEEN A TYROSINE AND A GLUTAMATE ARE TWO KEYS TO GATING IN KV1.2; A HYPOTHESIS BASED ON QUAN- TUM CALCULATIONS: THE SENSOR IS DYNAMIC, BASED ON HYDROGEN BOND REARRANGEMENTS, PRINCIPALLY IN WATER ROTATIONAL DEGREES OF FREEDOM, PLUS A PROTON PATHWAY. Alisher M. Kariev , Michael E. Green 525-Pos Board B305 STRUCTURAL INSIGHTS OF THE CALCIUMMEDIATED REORGANIZATION OF THE CALMODULIN/KV7.2 CHANNEL COMPLEX. Alvaro Villarroel , Ganeko Bernardo-Seisdedos, Alessandro Alaimo, Carolina Gomis-Perez, Araitz Alberdi, Covadonga Malo, Pilar Areso, Oscar Millet 526-Pos Board B306 CID TRAVEL AWARDEE BIOCHEMICAL ANALYSIS OF THE REGULATION OF KV7 CHANNELS BY PIP2 AND CALMODULIN. Crystal R. Archer , Benjamin T. Enslow, Mark S. Shapiro 527-Pos Board B307 CENTRIN 4 IS A BINDING PARTNER OF RAT EAG1 K + CHANNELS. Po-Hao Hsu, Chih-Yung Tang , Chung-Jiuan Jeng 528-Pos Board B308 GATING CURRENT MODELS COMPUTED WITH CONSISTENT INTERAC- TIONS. Tzyy-Leng Horng, Robert S. Eisenberg , Chun Liu, Francisco INTERNATIONAL TRAVEL AWARDEE A MOLECULAR SUBSTRATE FOR LONG QT IN HIV PATIENTS: TAT PROTEIN REDUCES IKR IN HUMAN INDUCED PLURIPOTENT STEM CELLS-DERIVED CARDIOMYOCYTES. Zeineb Es-Salah-Lamoureux , Mariam Jouni, Nadjet Belbachir, Marine Gandon-Renard, Bruno Beaumelle, Isabelle Baró, Flavien Charpentier, Kazem Zibara, Patricia Lemarchand, Nathalie Gaborit, Gildas Loussouarn 530-Pos Board B310 CHARACTERIZATION OF A FAST VOLTAGE-SENSING PROTEIN USING VOLTAGE-CLAMP FLUOROMETRY. Ferenc Papp , Jaime Smith, Orsolya Szilagyi, Tsg-Hui Chang, Kenton J. Swartz 531-Pos Board B311 PATCH-CLAMP FLUOROMETRY BASED DETERMINATION OF RELATIVE ION PERMEABILITY FOR HCN CHANNELS. Khade L. Grant, Chang Liu, Lei Zhou 532-Pos Board B312 DISTANCE-RESOLVING VOLTAGE CLAMP FLUOROMETRY (DRVCF) QUANTIFIES INTRAMOLECULAR TRANSITIONS IN THE HUMAN BK AND CI-VSP VOLTAGE SENSORS UNDER PHYSIOLOGICALLY-RELEVANT CONDI- TIONS. Antonios Pantazis , Riccardo Olcese 533-Pos Board B313 EFFECT OF SMALL-MOLECULES ON S4 MOVEMENT AND GATING OF NOR- MAL AND MUTATED IKM CHANNELS. Rene Barro-Soria Bezanilla 529-Pos Board B309

534-Pos Board B314 PROBING THE S4-S5 LINKER MOVEMENT DURING ACTIVATION IN KV CHANNELS. Tanja Kalstrup , Rikard Blunck 535-Pos Board B315 THE EFFECT OF MEMBRANE CHOLESTEROL CONTENT ON THE GATING MECHANISM OF VOLTAGE GATED POTASSIUM CHANNELS. Pal Pap, Zoltan Petho, Gyorgy Panyi, Zoltan Varga 536-Pos Board B316 THE CONSTRICTED FILTER CONFORMATION: A GENERAL PROPERTY FOR C-TYPE INACTIVATION OF DIFFERENT POTASSIUM CHANNELS?  Jing Li , Jared Ostmeyer, Mikolai Fajer, Benoit Roux 537-Pos Board B317 A RECIPROCAL VOLTAGE SENSOR-TO-PORE COUPLING IN C-TYPE INACTI- VATION. Luca Conti , Jakob Renhorn, Anders Gabrielsson, Fredrik Tures- son, Sara Liin, Erik Lindahl, Fredrik Elinder 538-Pos Board B318 DYN-MEDIATED INTERNALIZATION OF KCNQ1/KCNE1 CHANNELS UNDER SUSTAINED CPKC ACTIVATION. Xiaorong Xu Parks , Elsa Ronzier, Jin O- Uchi, Coeli M. Lopes 539-Pos Board B319 TRAFFICKING DEFICIENT KV11.1 (HERG) MUTATIONS LINKED TO LONG QT SYNDROME LOCALIZE TO DIFFERENT ENDOPLASMIC RETICULUM SUB- COMPARTMENTS. Jennifer L. Smith, Corey L. Anderson, Criag T. January, Brian Delisle 540-Pos Board B320 INTERACTIONS BETWEEN THE C-LINKER AND THE S4-S5 LINKER MEDIATE GATING IN CNGA1 CHANNELS. Manuel Arcangeletti, Monica Mazzolini, Claudio Anselmi, Debora Grosa , Sourav Maity, Arin Marchesi, Luisa Na- politano, Vincent Torre 541-Pos Board B321 ENGINEERING SUBUNIT AND NONSENSE SUPPRESSION STOICHIOMETRY IN POTASSIUM CHANNELS.  John D. Lueck , Adam L. Mackey, Jason D. Galpin, Christopher A. Ahern 542-Pos Board B322 SLACK CHANNELS NULL MICE EXHIBIT INCREASED SENSITIVITY TO ME- CHANICAL STIMULI BUT NORMAL RESPONSE TO THERMAL STIMULI. Ran Wang, Ying Song, Jie Xu, Meng-Jiao Tan, Tian-Yu Cao, Shun-Heng Gao, Meng-Han Sun, Fei-Fei Zhang, Zhe Zhang 543-Pos Board B323 EQUILIBRIUM FLUCTUATION RELATIONS FOR GATING CHARGE IN VOLT- AGE SENSITIVE MEMBRANE PROTEINS: A MICROSCOPIC CAPACITOR MODEL APPROACH.  ILSOO KIM , Arieh Warshel 544-Pos Board B324 MEMBRANE FORCES REGULATE VOLTAGE SENSOR MOVEMENT. Mehdi Torbati, Vikash Chaurasia, Kranthi Mandadapu, Ashutosh Agrawal 545-Pos Board B325 GATING CHARGE CALCULATIONS: PROBING VOLTAGE-SENSING PRO- TEINS THROUGH COMPUTATIONAL ELECTROPHYSIOLOGY.  Jan-Philipp Machtens , Rodolfo Briones, Bert L. de Groot, Christoph Fahlke 546-Pos Board B326 COMPUTATIONAL CHARACTERIZATION OF CONFORMATIONAL TRANSI- TIONS IN THE VOLTAGE-SENSING DOMAIN OF CI-VSP. Rong Shen , Qufei Li, David Medovoy, Yilin Meng, Benoît Roux, Eduardo Perozo 547-Pos Board B327 MODELING OF THE SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTAS- SIUM CHANNEL AND CARDIAC ALTERNANS. Matthew Kennedy , Donald M. Bers, Nipavan Chiamvimonvat, Daisuke Sato

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