Biophysical Society 60th Annual Meeting

548-Pos Board B328 WHAT DETERMINES THE CHARYBDOTOXIN SPECIFICITY AMONG KV1 POTASSIUM CHANNELS? Drew C. Tilley , Sarel Fleishman, Jon T. Sack, Vladimir Yarov-Yarovoy 549-Pos Board B329 THE MOLECULAR MECHANISM OF THE DUAL SPIDER TOXIN EFFECT ON VOLTAGE GATED K + CHANNELS. Sara Liin, Anders Gabrielsson, Fredrik Elinder, Erik Lindahl 550-Pos Board B330 IN-SILICO ELECTROPHYSIOLOGY: ON THE ACTIVATION OF VOLTAGE-GATED ION CHANNELS USING MOLECULAR DYNAMICS SIMULATIONS. Mounir Tarek , Lucie Delemotte, Marina Kasimova, Michael L. Klein, Vincenzo Carnevale 551-Pos Board B331 INSERTION OF CROSSLINKABLE AMINO ACIDS INTO THE I KS CHANNEL COMPLEX DEMONSTRATES A VARIABLE KCNQ1:KCNE1 STOICHIOMETRY OF UP TO 4:4. Maartje F.E. Westhoff , Christopher I. Murray, Emely Thompson, Robert Emes, Jodene Eldstrom, David Fedida Voltage-gated Na Channels I (Boards B332 - B361) 552-Pos Board B332 MOLECULAR SCALE PREDICTION OF LIDOCAINE INTERACTION WITH THE PORE DOMAIN OF HUMAN NAV1.5. Kevin DeMarco , Céline Boiteux, Toby W. Allen, Vladimir Yarov-Yarovoy, Colleen E. Clancy 553-Pos Board B333 A COMPUTATIONAL MODELING INVESTIGATION INTO SCN10A LINKED BRUGADA SYNDROME. Marcus Vincent , Pei-Chi Yang, Colleen E. Clancy 554-Pos Board B334 FACILITATION OF RAPID TEMPORAL PROCESSING BY ION CHANNEL COOP- ERATIVITY SUGGESTS COORDINATION THROUGH MEMBRANE ELECTRO- MECHANICS. Mussie K. Araya , William E. Brownell 555-Pos Board B335 COMPUTATIONAL MODELING OF SODIUM CHANNEL INACTIVATION. Kin Lam , Zhe Wu, Klaus Schulten 556-Pos Board B336 MOLECULAR DYNAMICS SIMULATIONS OF THE OPEN STATE STRUCTURE OF A BACTERIAL VOLTAGE-GATED SODIUM CHANNEL REVEAL THE BIND- ING MECHANISMS OF CHANNEL BLOCKERS. Song Ke , B. Ann Wallace, Jakob P. Ulmschneider, Martin B. Ulmschneider 557-Pos Board B337 COMPUTATIONAL STUDY OF BINDING OF μ-CONOTOXIN GIIIA (μ-CTX) TO NAVRH AND NAVAB. Dharmeshkumar J. Patel 558-Pos Board B338 BINARY ARCHITECTURE OF THE NAV1.2-β2 SIGNALING COMPLEX.  John M. Gilchrist , Samir Das, Filip Van Petegem, Frank Bosmans 559-Pos Board B339 STRUCTURAL COMPARISONS OF IMMUNOGLOBULIN FOLDS OF HUMAN NAVβ SUBUNITS. Samir Das , John Gilchrist, Frank Bosmans, Filip Van Board B340 CALMODULIN AND FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR CO-REGULATION OF THE NAV1.5 CHANNEL IN LQT3 MUTA- TIONS. Chaojian Wang , Haidun Yan, Geoffrey S. Pitt 561-Pos Board B341 INTRACELLULAR CALCIUM DIFFERENTIALLY AFFECTS SCN5A MIXED SYN- DROME MUTATIONS. Mena Abdelsayed , Peter C. Ruben Petegem 560-Pos

562-Pos Board B342 STRUCTURAL DIFFERENCES IN CALMODULIN BOUND TO VOLTAGATE- GATED SODIUM CHANNEL IQ MOTIFS. Ryan Mahling , C. Andrew Fowler, Liam Hovey, Liping Yu, Lokesh Gakhar, Zesen Lin, Nisha Pandey, Toni Martins, Madeline A. Shea 563-Pos Board B343 FUNCTIONAL MODIFICATION OF BACTERIAL VOLTAGE-GATED SODIUM CHANNELS BY BATRACHOTOXIN. Rocio K. Finol-Urdaneta , Jeffrey R. McArthur, Rachelle Gaudet, Robert J. French 564-Pos Board B344 MECHANOSENSITIVITY OF THE BACTERIAL VOLTAGE-GATED SODIUM CHANNEL NACHBAC. Constanza A. Alcaino , Peter R. Strege, Cheryl E. Bernard, Gianrico Farrugia, Arthur Beyder 565-Pos Board B345 EFFECTS OF LATE SODIUM CURRENT (INAL) BLOCKADE DURING ACUTE MYOCARDIAL ISCHEMIA. Carlotta Ronchi , Marcella Rocchetti, Eleonora Torre, Riccardo Rizzetto, Joyce Bernardi, Gaspare Mostacciulo, Antonio Zaza 566-Pos Board B346 NOVEL STORM-BASED QUANTITATIVE ASSESSMENT OF RELATIVE PROTEIN LOCALIZATION REVEALS NEW ROLE FOR SODIUM CHANNEL β1 SUBUNIT IN CARDIAC CONDUCTION. Rengasayee Veeraraghavan , Robert G. Gourdie 567-Pos Board B347 BIOPHYSICAL AND PHARMACOLOGICAL CHARACTERIZATION OF MUL- TIPLE NAV SUBTYPES ON QUBE. Mads P. Korsgaard , Anders Lindqvist, Søren Friis, Mette T. Christensen 568-Pos Board B348 CYSTEINE RESIDUES C489 AND C1135 OF NAV 1.5 PLAY A CRITICAL ROLE IN PRODUCING LATE SODIUM CURRENT THROUGH NNOS-DEPENDENT S-NITROSYLATION OF NAV 1.5.  Jianding Cheng , John W. Kyle, Graham S. Adsit, Carmen R. Valdivia, Alyson K. Fisher, Jonathan C. Makielski 569-Pos Board B349 MODULATION OF A BACTERIAL VOLTAGE-GATED SODIUM CHANNEL BY THE ANTI-EPILEPTIC DRUG LACOSAMIDE. Celine Boiteux, Chris French , Toby W. Allen 570-Pos Board B350 PATIENT-SPECIFIC INDUCED PLURIPOTENT STEM CELL CARDIAC MYO- CYTES AS PREDICTORS OF SUDEP RISK. Chad R. Frasier , Helen Zhang, James Offord, David S. Auerbach, Jack M. Paren, Lori L. Isom 571-Pos Board B351 BIOPHYSICAL, MOLECULAR AND PHARMACOLOGICAL CHARACTERIZA- TION OF NAV CHANNELS FROM INDUCED PLURIPOTENT STEM CELLS DERIVED CARDIOMYOCYTES. Aurélie Mercier , Adrien Moreau, Olivier Thériault, Mohamed Chahine 572-Pos Board B352 MICE WITH A NULL ALLELE FOR NAV1.4 EXHIBIT PSEUDO-MYASTHENIA, BUT ARE NOT SUSCEPTIBILE TO PERIODIC PARALYSIS. Fenfen Wu, Wentao Mi, Yu Fu, Steve C. Cannon 573-Pos Board B353 SCN4A PORE MUTATION PATHOGENETICALLY CONTRIBUTES TO AUTOSO- MAL DOMINANT ESSENTIAL TREMOR AND MAY INCREASE SUSCEPTIBIL- ITY TO EPILEPSY. Alberto Bergareche, Marcin J. Bednarz , Elena Sánchez, Catharine E. Krebs, Javier Ruiz-Martinez, Patricia De la Riva, Vladimir Makarov, Ana Gorostidi, Karin Jurkat-Rott, Jose Felix Marti-Masso, Coro Paisán-Ruiz

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