Biophysical Society 61st Annual Meeting | Program Guide

TRP Channels I (Boards B325–B336)

574-Pos Board B339 MYOFIBRILLAR REGULATORY MECHANISMS OF STRETCH ACTIVATION IN MAMMALIAN STRIATED MUSCLE.  Joel C. Robinett , Laurin M. Hanft, Kerry S. McDonald 575-Pos Board B340 EFFECT OF CALCIUM ON MYOSIN BINDING TO A REGULATED THIN FILA- MENT FROM SINGLE MOLECULE TO ENSEMBLE. Thomas Longyear, Sam Walcott , Edward P. Debold 576-Pos Board B341 COORDINATED VARIATIONS IN MYOSIN LIGHT CHAIN AND TROPONIN T ISOFORMS AND IN MAXIMAL SHORTENING VELOCITY IN HUMAN SLOW SKELETAL MUSCLE FIBERS. Peter J. Reiser 577-Pos Board B342 COMPUTATIONAL SIMULATIONS OF LOAD-DEPENDENT MYOSIN KINETICS DURING MUSCLE SHORTENING AND LENGTHENING. Axel J. Fenwick , Bertrand C.W. Tanner 578-Pos Board B343 CLEAVAGE OF SKELETAL MUSCLE MYOSIN LOOPS 1 AND 2 LEADS TO A DECREASED FUNCTION. Yu-Shu Cheng , Oleg Matusovskiy, Dilson Rassier 579-Pos Board B344 FORCE AND POWER OF A SYNTHETIC MYOSIN II-BASED MA- CHINE. Pasquale Bianco , Irene Pertici, Luca Melli, Giulia Falorsi, Danut- Adrian Cojoc, Tamás Bozó, Miklos Kellermayer, Vincenzo Lombardi 580-Pos Board B345 DISSECTING ACTOMYOSIN MECHANOCHEMISTRY USING BLEBBISTATIN AS A PHARMACOLOGICAL TOOL. Mohammad A. Rahman , Dilson Rassier, Alf Månsson 581-Pos Board B346 DEVELOPMENT AND PHENOTYPE STUDIES OF A SLOW SKELETAL TROPO- NIN T E180 NONSENSE MUTATION KNOCK-IN MOUSE LINE. Han-Zhong Feng , J.-P. Jin 582-Pos Board B347 SKELETAL MYOSIN-BINDING PROTEIN C MODULATES ACTOMYOSIN CONTRACTILITY IN AN ISOFORM-DEPENDENT MANNER. Amy Li , Shane Nelson, Kyounghwan Lee, Samantha Previs, Karen Brack, Michael Previs, Suresh Govindan, Sakthivel Sadayappan, Roger Craig, David Warshaw 583-Pos Board B348 EXPRESSION OF MYOSIN STORAGE MYOPATHY MUTATIONS IN DRO- SOPHILA DISRUPTS MUSCLE FUNCTION, MYOFIBRILLAR STRUCTURE AND CAUSES DEFECTS IN THICK FILAMENT ASSEMBLY. Meera C. Viswanathan , Rick Tham, William A. Kronert, William Schmidt, Floyd Sarsoza, Adrianna S. Trujillo, Sanford I. Bernstein, Anthony Cammarato 584-Pos Board B349 A SIMPLIFIED FLEXIBLE CHAIN MODEL OF CALCIUM REGULATED MYOSIN- ACTIN INTERACTION. Leonard P. Heinz , Rainer H. A. Fink 585-Pos Board B350 RECONSTRUCTION OF FUNCTIONAL INSECT FLIGHT MUSCLE FIBERS WITH RABBIT SKELETAL MUSCLE ACTIN. Hiroyuki Iwamoto 586-Pos Board B351 THE SKELETAL MUSCLE MOLECULAR CLOCK REGULATES TITIN ISOFORM EXPRESSION. Lance A. Riley , Xiping Zhang, Karyn A. Esser 587-Pos Board B352 CACIUM-INDUCED SR CALCIUM LEAK IN DYSFERLIN-NULL MURINE MUSCLE FIBERS. Valeriy Lukyanenko , Joaquin Muriel, Robert J. Bloch

560-Pos Board B325 BINDING OF EXTRACELLULAR CA 2+ TO THE SPECIFIC AMINO ACIDS IS REQUIRED FOR HEAT-EVOKED ACTIVATION OF TRPA1. Erkin Kurganov , Shigeru Saito, Claire T. Saito, Makoto Tominaga 561-Pos Board B326 OLIGOMERIC AND THERMAL STABILITY OF TRPA1 COILED-COIL DOMAIN BY POLYPHOSPHATES. Gilbert Q. Martinez , Luke D. Cody, Sharona E. Board B327 TOWARD ELUCIDATING THE HEAT ACTIVATION MECHANISM OF THE TRPV1 CHANNEL GATING BY MOLECULAR DYNAMICS SIMULATION. Han Wen, Feng Qin, Wenjun Zheng 563-Pos Board B328 THE EMERGING ROLE OF HUMAN TRPV1 S1 S4 SENSING DOMAIN IN CHANNEL GATING. Minjoo Kim , Nicholas Sisco, Jacob Hilton, Wade Van Horn 564-Pos Board B329 INACTIVATION IN TRPV1 ION CHANNELS. Leon D. Islas , Ana Sanchez- Moreno, Gisela Rangel-Yescas, Ernesto Ladron de Guevara, Tamara Rosenbaum 565-Pos Board B330 KINETIC ANALYSIS OF VANILLOID-INDUCED ACTIVATION IN TRPV1 CHAN- NEL. Simon Vu , Bo Hyun Lee, Jie Zheng 566-Pos Board B331 Education Travel Awardee RATIONAL DESIGN AND VALIDATION OF A VANILLOID-SENSITIVE TRPV2 ION CHANNEL. Fan Yang , Simon Vu, Vladimir Yarov-Yarovoy, Jie Zheng 567-Pos Board B332 LOCALIZATION OF THE TEMPERATURE SENSORS TO THE PORE DOMAIN OF THE TRPV1 CHANNEL. Feng Zhang , Sonya Hanson, Andres Andres Jara-Oseguera1, Kenton Swartz 568-Pos Board B333 TRANSFER OF TRPV1 SODIUM BINDING SITE INTO TRPV2. Katherine E. Huffer , Andrés Jara-Oseguera, Kenton J. Swartz 569-Pos Board B334 INVESTIGATING THE PUTATIVE ACTIVATION GATE IN THE SELECTIVITY FILTER OF THE TRPV1 CHANNEL. Andres Jara-Oseguera , Kenton J. Swartz 570-Pos Board B335 THE MECHANISM OF REGULATION OF TRPV6 CHANNELS BY PI(4,5) P 2 . Marina Kasimova, Aysenur Yazici, Chike Cao, Phanindra Velisetty, Vincenzo Carnevale, Tibor Rohacs 571-Pos Board B336 THE ROLE OF THE SENSING DOMAIN (S1-S4) IN TRPM8 TEMPERATURE AND MENTHOL DEPENDENT GATING. Parthasarathi Rath Skeletal Muscle Mechanics, Structure, and Regulation (Boards B337–B354) 572-Pos Board B337 MODULATION OF FAST TRANSIENTS BY COMPLIANCE OF CROSSBRIDGES AND MYOFILAMENTS. Srboljub M. Mijailovich , Djordje Nedic, Boban Stojanovic, Thomas C. Irving, Michael A. Geeves 573-Pos Board B338 INCREASED NON-UNIFORMITY IN IN VIVO SARCOMERE LENGTH DURING A TETANIC CONTRACTION. Eng Kuan Moo , Timothy R. Leonard, Walter Herzog Gordon 562-Pos

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