Biophysical Society 61st Annual Meeting | Program Guide

Transporters and Exchangers I (Boards B392 –B405)

613-Pos Board B378 THE HERG1/BETA1 INTERACTION COMPROMISES THE MECHANO-RECIPROCITY OF PANCREATIC CANCER. Stefano Coppola , Annarosa Arcangeli, Thomas Schmidt 614-Pos Board B379 MECHANICAL PROPERTIES OF NORMAL BREAST CELLS AND METASTATIC CANCER CELLS IN CO-CULTURE. Hyunsu Lee , Amanda Smelser, Josiah Low, Martin Guthold, Keith Bonin 615-Pos Board B380 KAPPA-ACTIN ALTERS HEPATOCELLULAR CARCINOMA PHYSIOLOGY IN CIRRHOTIC MICROENVIRONMENT. Chi-Shuo Chen , Cheng-Yi Lin, Chi-Hung Ho, Wei-Chi Wu 616-Pos Board B381 IS SHAPE OF CANCER CELL CORRELATED WITH ITS INVASIVENESS? Elaheh Alizadeh , Samanthe M. Lyons, Jordan M. Castle, Jacqueline Irene Foss, Ashok Prasad 617-Pos Board B382 STABILITY ON THE EDGE: PROBING THE BIOPHYSICAL MECHANISMS OF POLARITY MAINTENANCE AT THE LEADING EDGE OF MOTILE NEUTRO- PHIL-LIKE HL-60 CELLS. Rikki M. Garner , Elena Koslover, Julie Theriot 618-Pos Board B383 CID Travel Awardee UNDERSTANDING THE MECHANICS OF NEUTROPHIL MIGRATION IN THREE- DIMENSIONAL EXTRACELLULAR MATRICES.  Joshua Francois , Ruedi Meili, Juan Carlos del Alamo, Richard Firtel, Juan C. Lasheras 619-Pos Board B384 CPOW Travel Awardee NOVEL MECHANISM FOR DRIVING AMOEBOID-LIKE MOTILITY OF HU- MAN NEUTROPHILS UNDER AN ELECTRIC FIELD, BASED ON INTRACEL- LULAR PROTON CURRENTS AND CYTOPLASM STREAMING. Hagit Peretz Soroka , Reuven Tirosh, Murray Alexander, Jolly Hipolito, Francis Lin 620-Pos Board B385 Education Travel Awardee MACROPHAGES ARE SENSITIVE TO SUBSTRATE ELASTICITY DURING PHAGOCYTOSIS. Wolfgang Gross , Franziska Zecherle, Kathrin Weidner- Hertrampf, Holger Kress 621-Pos Board B386 INVESTIGATING ACTIN MECHANICS DURING PHAGOCYTIC UPTAKE AND TRANSPORT. Konrad Berghoff , Steve Keller, Holger Kress 622-Pos Board B387 B CELL ANTIGEN EXTRACTION IS REGULATED BY PHYSICAL PROPERTIES OF ANTIGEN PRESENTING CELLS. Katelyn M. Spillane , Pavel Tolar 623-Pos Board B388 REVEALING THE MECHANICAL BASIS OF T CELL SIGNALING. Khalid Salaita 624-Pos Board B389 MECHANICS OF BLOOD CELLS WITH MARGINAL BAND : COMPETITION BETWEEN CORTICAL TENSION AND RIGIDITY. Serge A. Dmitrieff , Adolfo Alsina, Mathur Aastha, Nédélec François 625-Pos Board B390 MULTISCALE MODELING OF RED BLOOD CELLS SQUEEZING THROUGH SUBMICRON SLITS. Huijie Lu , Zhangli N. Peng 626-Pos Board B391 ROLLING ADHESION OF MALARIA-INFECTED RED BLOOD CELLS. Anil Kumar Dasanna

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627-Pos Board B392 MARKOV STATE-BASED QUANTITATIVE KINETIC MODEL OF SODIUM RELEASE FROM THE DOPAMINE TRANSPORTER. Asghar Razavi , George Khelashvil, Harel Weinstein 628-Pos Board B393 OLIGOMERIZATION OF HUMAN DOPAMINE TRANSPORTER (HDAT).  Kumaresan Jayaraman , Harald H. Sitte, Thomas Stockner 629-Pos Board B394 TWO MECHANISMS IN ONE FAMILY: PACKAGING OF GLUTAMATE INTO SYNAPTIC VESICLES AGAINST A PROTON GRADIENT, A TRANSPORTER DRIVEN BY MEMBRANE POTENTIAL, VERSUS A HOMOLOG DRIVEN DOWNHILL WITH PROTON GRADIENTS. Robert M. Stroud 630-Pos Board B395 SUBSTRATE BINDING TO SEROTONIN TRANSPORTERS REDUCES MEM- BRANE CAPACITANCE. Verena Burtscher , Matej Hotka, Walter Sandtner 631-Pos Board B396 EXPLORING LIGAND-BINDING KINETICS IN THE S2 SITE OF MHST BY AT- OMISTIC SIMULATIONS AND MARKOV MODELS. Ara M. Abramyan , Cathy Xue, Lei Shi 632-Pos Board B397 COMPUTATIONAL INVESTIGATION OF THE SEROTONIN TRANSPORTER CONFORMATION AND RESET MECHANISM. Emily M. Benner , Jeffry D. Board B398 CHARACTERIZING OUTWARD- TO INWARD-FACING TRANSITION PATH- WAY OF DOPAMINE TRANSPORTER. Zhiyu Zhao , Emad Tajkhorshid 634-Pos Board B399 Education Travel Awardee STRUCTURAL INSIGHTS INTO SODIUM-DEPENDENT SUGAR TRANSPORT- ERS AND THEIR INHIBITION MECHANISM. Paola Bisignano , Chakrapani Kalyanaraman, Chiara Ghezzi, Ernest M. Wright, Jeff Abramson, Aviv Paz, Matthew P. Jacobson, Rosmarie Friemann, Michael Grabe 635-Pos Board B400 UPTAKE DYNAMICS IN THE LACY MEMBRANE PROTEIN TRANSPORT- ER. Dari Kimanius, Stephen White, Erik Lindahl, Ronald Kaback, Magnus Andersson 636-Pos Board B401 ELEVATOR-LIKE MECHANISM OF TRANSPORT IN THE EIIC GLUCOSE SU- PERFAMILY OF TRANSPORTERS. Zhenning Ren , Yin Nian, Jumin Lee, Jason McCoy, Wonpil Im, Ming Zhou 637-Pos Board B402 SUBSTRATE-INDUCED CONFORMATIONAL CHANGE IN LEUT. Yuan-Wei Zhang, Lucy R. Forrest, Gary Rudnick 638-Pos Board B403 MEMBRANE REMODELING BY GLT PH IN THE INWARD- AND OUTWARD- FACING CONFORMATIONS EXPLAINS LACK OF PROTOMER COOPERATIV- ITY. Wenchang Zhou , Claudio Anselmi, Horacio Poblete, Ali Karimi, Lucy Forrest, Jose Faraldo-Gomez 639-Pos Board B404 PROTEIN-PROTEIN INTERACTION BETWEEN SODIUM-COUPLED MONO- CARBOXYLATE TRANSPORTER 1 (SMCT1) AND PDZ DOMAIN-CONTAINING RING FINGER DOMAIN 3 (PDZRN3). Yusuke Otsuka Madura 633-Pos

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