Biophysical Society 62nd Annual Meeting | Program Guide

Platform Voltage-gated K Channels I 8:15 am–10:15 am, Esplanade, Room 155

1855-Plat 8:45 am ASSESSING THE TRANSLOCATION OF CELL PENETRATING PEPTIDES USING FORCE MEASUREMENTS, ELECTROPHYSIOLOGY AND EMULSIONS.  Simon Kulifaj , Sophie Cribier, Vincent Vivier, Nicolas Rodriguez, Kieu Ngo 1856-Plat 9:00 am MELITTIN-INDUCED PERMEABILIZATION, RE-SEALING, AND RE-PERMEA- BILIZATION OF E. COLI MEMBRANES.  Zhilin Yang , Heejun Choi, James Weisshaar 1857-Plat 9:15 am THE ANTIMICROBIAL PEPTIDE PISCIDIN P1 USES WEAK SPOTS IN MEM- BRANES AS SITES OF ACTION.  Laura Lucas, Roderico Acevedo, Myriam Cotten, Ella Mihailescu 1858-Plat 9:30 am AB-INITIO PREDICTION OF ANTIMICROBIAL PEPTIDES CHANNELS IN MEMBRANES.  Jakob Ulmschneider 1859-Plat 9:45 am ANTIMICROBIAL SELECTIVITY AND MEMBRANE LEAKAGE MECHANISMS: THE ROLE OF LIPIDS.  Anja Stulz, Larissa Akil, Karen Lienkamp, Maria Hoernke 1860-Plat 10:00 am THE CELL CYCLE DEPENDENCE OF THE ACTIVITY OF ANTIMICROBIAL PEPTIDES RESULTS IN A HIGHER RESISTANCE OF STARVING CELLS TO THE PEPTIDES. Mehdi Snoussi, Mehrnaz Siavoshi, Paul Talledo, Sattar Taheri-Araghi Subgroup Chairs Meeting 9:00 am–10:30 am, South, Level Three, Room 313 Career Development Center Workshop Looking Beyond Academia: Identifying Your Career Options Using MyIDP, Linkedin, and More 9:30 am–10:30 am, South, Lower Level, Room 2 Not sure where your professional future lies or how to approach the process in an organized and strategic manner? This presentation provides a framework and resources for moving forward with confidence towards the next step in your professional future. In addition, it will provide specific examples of how to build out your knowledge of a new potential career field and forge valuable connections that can facilitate a successful transition. Exhibits 10:00 am–4:00 pm, Exhibit Hall ABC Coffee Break 10:15 am–11:00 am, Exhibit Hall ABC

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Co-Chairs David Jones, University of Wisconsin Francesco Tombola, University of California, Irvine 1845-Plat 8:15 am

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THE HERG PAS DOMAIN FACILITATES GATING CHARGE DEACTIVATION AT PHYSIOLOGICAL TEMPERATURE.  David K. Jones , Carol Harley, Anthony Amolo, Joao Morais-Cabral, Gail A. Robertson 1846-Plat 8:30 am EXPLOITING Π-STACKING INTERACTIONS TO IMPROVE INHIBITION OF THE HV1 CHANNEL BY AROMATIC GUANIDINE DERIVATIVES.  Chang Zhao , Liang Hong, Jason D. Galpin, Christopher A. Ahern, Francesco Tombola 1847-Plat 8:45 am IDENTIFICATION OF THE C-LINKER AND CNBD RESIDUES ACCOUNTING FOR THE HIGH EFFICACY OF CAMP ACTIVATION IN HCN2 CHANNELS.  Claudia P. Alvarez Baron , Vadim A. Klenchin, Baron Chanda 1848-Plat 9:00 am ATOM-BY-ATOM TUNING OF AN ELECTROSTATIC POTASSIUM-CHANNEL MODULATOR. Malin Silverå Ejneby , Xiongyu Wu, Nina E. Ottosson, E. Peter Münger, Ingemar Lundström, Peter Konradsson, Fredrik Elinder 1849-Plat 9:15 am AN ALLOSTERIC ACTION MECHANISM OF A K + PORE BLOCKER REVEALED AT THE ATOMIC LEVEL.  Izhar Karbat , Hagit Altman-Gueta, G. Tibor Szanto, Shelly Hamer-Rogotner, Orly Dym, Felix Frolow, Dalia Gordon, Gyorgy Panyi, Michael Gurevitz, Eitan Reuveny 1850-Plat 9:30 am VOLTAGE-GATED CHANNEL REGULATION BY AN amINO ACID TRANSPORTER.  Victoria A. Baronas , Runying Yang, Harley T. Kurata 1851-Plat 9:45 am MOLECULAR MECHANISM UNDERLYING A TRADITIONAL ANTICONVUL- SANT: SYNERGISTIC KCNQ2/3 POTASSIUM CHANNEL ACTIVATION BY DUAL COMPONENTS OF MALLOTUS OPPOSITIFOLIUS EXTRACT.  Rían Manville , Maria Papanikolaou, Geoffrey W. Abbott 1852-Plat 10:00 am THE MORBIDITY OF EPILEPSY AND CARDIAC ARRHYTHMIA IS ATTRIBUTED TO COMMON CHANNELOPATHY OF GENETIC MUTANTS OF SLACK CHAN- NELS.  Yun Xu, Fei-Fei Zhang, Jie Xu, Wen Sun, Xiao-Yun Zhao, Qiong-Yao Tang, Zhe Zhang Platform Membrane Active Peptides and Toxins 8:15 am–10:15 am, Esplanade, Room 156 Co-Chairs Mibel Aguilar, Monash University, Australia WilliamWimley, Tulane University 1853-Plat 8:15 am MEMBRANES MATTER: PREDICTING DRUG TOXICITY.  R. Lea Sanford , Jeanne Chiaravalli-Giganti, Wesley Chao, J. Fraser Glickman, Olaf S. Andersen 1854-Plat 8:30 am MECHANISM OF ACTION OF PH-TRIGGERED, MEMBRANE ACTIVE PEP- TIDES: EFFECT OF NEGATIVE CHARGE.  Sarah Y. Kim , William C. Wimley, Kalina Hristova

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Exhibitor Presentation Sophion Bioscience A/S 10:30 am–12:00 pm, Exhibit Hall, Room 6

Ion Channel Profiling and Electrophysiological Characterization Using Automated Patch Clamp (QPatch), Cell Line Generation, and iPSC Derived Cardiomyocytes: Tools for Finding Antibodies and Peptides for Ion Channel Targets Successful ion channel drug discovery requires the integration of multiple technologies and workflows. Sophion Bioscience is a leader in automated patch clamp technology, providing medium to high throughput, auto- mated patch clamp to the pharmaceutical industry and universities. The QPatch is a fully automated patch clamp system, executing simultaneous

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