Biophysical Society 62nd Annual Meeting | Program Guide

2382-Pos Board B398 THE GQ-GPCR PATHWAY EVOKES TIGHTLY CONTROLLED TRPV1 ACTIVA- TION. Adina T. Hazan 2383-Pos Board B399 ACTIVATION OF TRPV1 BY CAPSAICIN ANALOGS WITH A SHORTER OR LONGER NECK. Simon Vu , Vikrant Singh, Fan Yang, Heike Wulff, Jie Zheng 2384-Pos Board B400 EXPRESSION AND PURIFICATION OF THE PAIN RECEPTOR TRPV1 FOR SPECTROSCOPIC ANALYSIS. Phanindra Velisetty, Richard A. Stein, Francisco J. Sierra Valdez , Valeria Vásquez, Julio F. Cordero-Morales 2385-Pos Board B401 CELL UNROOFING TO STUDY THE PI3K-TRPV1 INTERACTION. Gabriela Bergollo Drouyn , Anastasiia Stratiievska, Sharona Gordon 2386-Pos Board B402 RECIPROCAL REGULATION OF PI3K BY TRPV1 DURING INFLAMMA- TION. Anastasiia Stratiievska , Gabriela Bergollo, Sara Nelson, Sharona Gordon 2387-Pos Board B403 BINDING OF CAPSAICIN SLOWS DOWN PROTON-INDUCED TRPV1 ACTIVA- TION. Bo Hyun Lee , Jie Zheng 2388-Pos Board B404 FUNCTIONAL ANALYSIS OF TRPV1 CHANNELS WITH A GENETICALLY ENCODED CROSS-LINKER. Deny Cabezas-Bratesco , Christopher A. Ahern, Sebastián Brauchi 2389-Pos Board B405 REGULATION OF TRPV 1 EXPRESSION IN NON-NEURONAL TISSUES BY BDNF, SP 1 , AND SP 4 . Rebecca Brenner , Padmamalini Baskaran, Baskaran Thyagarajan 2390-Pos Board B406 CHALCONES DERIVATIVES AS POTENT INHIBITORS OF TRPV1 ACTIV- ITY. Bruna Benso , Carolyne Lespay-Rebolledo, Lisandra Flores, Miguel Zárraga, Sebastian Brauchi 2391-Pos Board B407 MECHANISMS BY WHICH BOTULINUM NEUROTOXIN A SUPPRESSES PAIN. Baskaran Thyagarajan , Louis Premkumar, Padmamalini Baskaran 2392-Pos Board B408 SUB-CHRONIC ORAL SAFETY ANALYSIS OF METABOCIN TM . Padmamalini Baskaran, Laurel Markert, Liesl Zimmerman, Jane Bennis, Baskaran Thyagarajan 2393-Pos Board B409 TRPV2 IS CRUCIAL FOR THE DEVELOPMENT OF EXCITATION-CONTRAC- TION COUPLING IN NEONATAL CARDIOMYOCYTES. Yuki Katanosaka , Yoshihiro Ujihara, Yumiko Chiba, Satoshi Mohri, Keiji Naruse 2394-Pos Board B410 MOLECULAR MECHANISM OF TRPV2 CHANNEL PORE DYNAMICS DURING LIGAND ACTIVATION. Amrita Samanta , Yuhang Liu, Franklin Mayca Pozo, George R. Dubyak, Taylor E.T. Hughes, Seungil Han, David T. Lodowski, Vera Y. Moiseenkova-Bell 2395-Pos Board B411 EVOLUTIONARY VARIATIONS IN HLH DOMAIN MODULATE THE FAST INACTIVATION PHASE IN CALCIUM SELECTIVE TRP CHANNELS. Lisandra Flores Aldama , Daniel Bustos, Juan G. Opazo, Wendy González, Sebastián Brauchi 2396-Pos Board B412 SELECTIVE INHIBITION OF THERMOSENSITIVE TRPV3 CHANNEL BY NATURAL COUMARIN OSTHOLE FOR ITCH RELIEF. Xiaoying Sun , Lilan Sun, Ningning Wei, Kewei Wang

2369-Pos Board B385 ALPHA-B HELIX OF THE RCK1 DOMAIN IS A SHARED STRUCTURAL ELE- MENT FOR BOTH VOLTAGE AND CALCIUM ACTIVATION OF BK CHAN- NELS. Yanyan Geng , Zengqin Deng, Guohui Zhang, Alice Butler, Jianmin Cui, Peng Yuan, Lawrence Salkoff, Karl L. Magleby 2370-Pos Board B386 ROLE OF AN INTRASUBUNIT CA 2+ BRIDGE DEPENDENT ACTIVATION OF BK CHANNELS. Alberto J. Gonzalez-Hernandez , Aravind Kshatri, Teresa Giraldez 2371-Pos Board B387 COUPLING BETWEEN SENSORS AND THE ACTIVATION GATE IN BK CHAN- NELS PROBED BY A CHEMICAL COMPOUND. Guohui Zhang, Xianjin Xu, Hongwu Liang, Jingyi Shi, Kelli McFarland, Xiaoqin Zou, Jianmin Cui 2372-Pos Board B388 QUANTITATIVE ANALYSIS OF SUBCELLULAR NANODOMAINS FORMED BY BK AND VOLTAGE-GATED CALCIUM CHANNELS. Alejandro Cerrada , Aravind Kshatri, Roger Gimeno, Teresa Giráldez 2373-Pos Board B389 NOVEL TOPOLOGY OF BK CHANNEL BETA1 SUBUNIT PREDICTED ON THE BASIS OF THE “POSITIVE-INSIDE” RULE POINTS AT AN INTRACELLULAR LO- CATION OF THE LOOP. Maria Simakova, Shivantika Bisen, Kelsey Cleland, Avia Rosenhouse-Dantsker, Alex Dopico, Anna Bukiya 2374-Pos Board B390 ELIMINATING WARRANTLESS ASSUMPTIONS FACILITATES CONSIDER- ATION OF AN ELECTROSTATIC MODEL OF ION-CHANNEL ACTIVATION. H. Richard Leuchtag 2375-Pos Board B391 MULTICOMPONENT CONDUCTION AND SELECTIVITY OF BIOLOGICAL CHANNELS. Dmitry G. Luchinsky , Will A T Gibby, Igor Kh Kaufman, Miro- slav Barabash, Dogan A. Timucin, Peter V E McClintock TRP Channels I (Boards B392–B416) 2376-Pos Board B392 DECRYPTING THE HEAT ACTIVATION MECHANISM OF TRPV1 CHANNEL BY MOLECULAR DYNAMICS SIMULATION. Wenjun Zheng , Han Wen 2377-Pos Board B393 HEAT SENSITIVE GATING MECHANISM OF TRPV1 CHANNEL REVEALED BY MOLECULAR DYNAMICS SIMULATION. Soon Woo Park , Soojin Jo, Moon Ki Kim 2378-Pos Board B394 THERMAL DIFFUSION PATHWAYS OF TRPV1. Fernando D. Gonzalez-Nilo , Ignacio Diaz-Franulic, Romina V. Sepulveda, Felipe A. Gomez-Becerra, German Mi o-Galaz, Ramon Latorre 2379-Pos Board B395 ROLE OF HYDROPHOBIC SOLVATION IN TRPV1 TEMPERATURE SENSI- TIVITY. Marina Kasimova, Aysenur Yazici, Yevgen Yudin, Tibor Rohacs, Vincenzo Carnevale 2380-Pos Board B396 ROTATIONAL BROWNIAN MOTION OF TRPV1 CHANNEL OBSERVED BY SYNCHROTRON DIFFRACTED X-RAY TRACKING AND LABORATORY X-RAY BLINKING ANALYSIS. Kazuhiro Mio , Masahiro Kuramochi, Ken Matsubara, Keigo Ikezaki, Muneyo Mio, Hiroshi Sekiguchi, Tai Kubo, Yuji C. Sasaki 2381-Pos Board B397 A BIMODAL ACTIVATION MECHANISM UNDERLIES SCORPION TOXIN- INDUCED PAIN. Shilong Yang, Fan Yang , Bei Zhang, Bo Hyun Lee, Bowen Li, Lei Luo, Jie Zheng, Ren Lai

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