Biophysical Society 62nd Annual Meeting | Program Guide

2409-Pos Board B425 IDENTIFICATION OF A MODULATORY SITE OF ACTION FOR THE VOLATILE ANESTHETIC ISOFLURANE IN TREK1 TANDEM PORE POTASSIUM CHAN- NELS. Paul M. Riegelhaupt , Kellie A. Woll, Thomas T. Joseph, Kiran A. Vaidya, Crina M. Nimigean, Roderic G. Eckenhoff 2410-Pos Board B426 VX-770-MEDIATED POTENTIATION OF NUMEROUS HUMAN CFTR DISEASE MUTANTS IS INFLUENCED BY PHOSPHORYLATION LEVEL. Guiying Cui , Brandon Stauffer, Barry Imhoff, Andras Rab, Nael McCarty 2411-Pos Board B427 FLOS MAGNOLIAE AND ITS CHEMICAL CONSTITUENTS MODULATE CL - SECRETION VIA ANO1 CL - CHANNEL INHIBITION IN HUMAN AIRWAY EPITHELIAL CELLS. Hyun Jong Kim , Yu-Ran Nam, Joo Hyun Nam, Woo Kyung Kim 2412-Pos Board B428 IDENTIFICATION OF POTENT AND SELECTIVE INHIBITORS TO INVESTIGATE THE ROLE OF EPITHELIAL SODIUM CHANNELS IN NEURODEGENERA- TION. Victoria Miller , John Atack, Martin Gosling 2413-Pos Board B429 DIVERSE PHARMACOLOGICAL EFFECTS OF CARBON MONOXIDE-RELEAS- ING MOLECULES ON MITOCHONDRIAL BK CHANNEL. Daria Rotko , Piotr Bednarczyk, Adam Szewczyk 2414-Pos Board B430 FLEXIBILITY OF A TRANSMEMBRANE HELIX UNDERLIES DRAMATIC REVER- SAL OF NET ANESTHETIC EFFECTS IN A PENTAMERIC LIGAND-GATED ION CHANNEL. Stephanie A. Heusser , Marie Lycksell, Xueqing Wang, Rebecca J. Howard, Erik Lindahl 2415-Pos Board B431 OPTOGENETIC TECHNOLOGIES ENABLE HIGH THROUGHPUT ION CHAN- NEL DRUG DISCOVERY AND TOXICITY SCREENING. Riccardo Rizzetto , Viviana Agus, Sara Pizzi, Jean-Francois Rolland, Lia Scarabottolo, Susanne Renhelt, Daniela Malan, Tobias Bruegmann, Philipp Sasse, Krisztina Ju- hasz, Leo Doerr, Matthias Beckler, Michael George, Andrea Brüggemann, Niels Fertig 2416-Pos Board B432 MECHANISMS UNDERLYING RATE-DEPENDENT EFFECTS OF STATE- SPECIFIC BINDING OF SODIUM CHANNEL BLOCKERS IN CARDIAC TISSUE: INSIGHTS FROM IDEALIZED MODELS. Steffen S. Docken , Timothy J. Lewis, Colleen E. Clancy 2417-Pos Board B433 HIGHLY PARALLEL ALL-OPTICAL REAL-TIME INTERROGATION OF FAST VOLTAGE-GATED ION CHANNELS USING MOLECULAR WIRE VOLTAGE- SENSING COMPOUNDS. Thomas Lila, Jay Trautman, Stephen Smith, Andrew Blatz 2418-Pos Board B434 BUNYAVIRUSES ARE DEPENDENT ON K 2P CHANNELS TO INFECT CELLS.  Samantha Hover , John N. Barr, Steve AN Goldstein, Jamel Mankouri 2419-Pos Board B435 MINOCYCLINE AND DOXYCYCLINE INHIBIT ASIC CURRENTS IN DORSAL ROOT GANGLION NEURONS. Laura C. Caba Sánchez , Rosario Vega, Au- drey M. Ortega, Ricardo Félix, Enrique Soto 2420-Pos Board B436 AN SCN1B VARIANT FOUND IN A CHILD DIAGNOSED WITH EPILEPSY AND BRUGADA SYNDROME MODIFIES BRAIN-TYPE (NA V 1.1) AND CARDIAC- TYPE (NA V 1.5) SODIUM CURRENTS. Rebecca Martinez-Moreno , Helena Riuró, Elisabeth Selga, Michael F. Wangler, Ramon Brugada, Guillermo J. Pérez, Fabiana S. Scornik

2397-Pos Board B413 TARGETING INFLAMMATION IN POST-OPERATIVE ATRIAL FIBRILLATION: THE ROLE OF TRPV4 IN AUGMENT NEUTROPHIL INFILTRATION VIA UP- REGULATION IL6 AND CXCL2. Shao-Shao Zhang , Qiong-Feng Wu, Chen Qian, Huixia Liu, Bin-bin Wang, Jie Liao, Lei Chen, Yi-Mei Du 2398-Pos Board B414 BLOCKADE OF TRANSIENT RECEPTOR POTENTIAL VANILLOID 4 ENHANCES ANTIOXIDATIVE ACTIVITY AND ATTENUATES HYPOXIA/REOXYGENATION INJURY IN CARDIOMYOCYTES: INVOLVEMENT OF AKT/NRF2/ARE. Qiong- Feng Wu , Qian Dong, Shao-Shao Zhang, Bin-Bin Wang, Jie Liao, Lei Chen, Board B415 TRPV4 CHANNEL IS AN OSMOSENSOR AND MECHANOSENSOR IN PROXI- MAL TUBULE CELLS. Roberta Gualdani , Francois Seghers, Xavier Yerna, Philippe Gailly 2400-Pos Board B416 MOLECULAR DYNAMICS INSIGHTS INTO TRPV5 CHANNEL INHIBITION BY SMALL MOLECULES. Abhijeet Kapoor , Taylor E.T. Hughes, David T. Lodowski, Vera Y. Moiseenkova-Bell, Marta Filizola Ion Channels, Pharmacology, and Disease II (Boards B417–B439) 2401-Pos Board B417 STRUCTURAL MODELING OF HERG CHANNEL INTERACTIONS WITH DRUGS USING ROSETTA. Aiyana M. Emigh , Kevin R. DeMarco, Kazuharu Furutani, Slava Bekker, Jon T. Sack, Colleen E. Clancy, Igor Vorobyov, Vladi- mir Yarov-Yarovoy 2402-Pos Board B418 SUBUNIT ORGANIZATION OF K2P CHANNELS. Guillaume Sandoz 2403-Pos Board B419 INHIBITION OF NPC1 INCREASES NEURONAL EXCITABILITY BY CHANGING PHOSPHOINOSITIDE LEVELS. Oscar Vivas , Scott Tiscione, Eamonn Dickson 2404-Pos Board B420 MOLECULAR DETERMINANTS OF STEROID HORMONE AND DRUG IN- DUCED ARRHYTHMOGENESIS VIA HERG CHANNEL BLOCK.  Igor Vorobyov , Brandon M. Brown, Kevin R. DeMarco, Sergei Y. Noskov, Vladimir Yarov- Yarovoy, Heike Wulff, Colleen E. Clancy 2405-Pos Board B421 INCREASED PANNEXIN 1 EXPRESSION AND ACTIVITY IN VENTRICLE OF MDX DYSTROPHIC HEARTS. Frank J. Raucci, Jr , Kyunsoo Kim, Sabine Huke, Bjorn C. Knollmann 2406-Pos Board B422 MECHANISM OF SELECTIVE ACTION OF A SMALL MOLECULE ACTIVA- TOR OF PHOSPHOINOSITIDE-DEPENDENT GIRK CHANNELS. Yu Xu , Lucas Noah Cantwell, Yuchen Yang, Sumanta Garai, Abhijit Kulkarni, Takeharu Kawano, Ganesh Thakur, Diomedes Logothetis 2407-Pos Board B423 ENGINEERED TRANSFER RNA SUPPRESSION OF CFTR NONSENSE MUTA- TIONS.  John D. Lueck , Adam L. Mackey, Daniel T. Infield, Marshall R. Pope, Paul B. McCray, Christopher A. Ahern 2408-Pos Board B424 IPSC-DERIVED NEURONS HARBORING A KNOWN EPILEPSY MUTATION PROVIDE A ‘DISEASE-IN-A-DISH’ CAPABILITY THAT DISPLAYS ESTABLISHED AND NOVEL EPILEPTIC PHENOTYPES. Kile P. Mangan , Imran Quraishi, Ya- lan Zhang, Michael McLachlan, Benjamin Meline, Chris McMahon, Elisa- beth Enghofer, Christian Kannemeier, Eugenia Jones, Leonard Kaczmarek Yi-Mei Du 2399-Pos

T U

E S

D A Y

137