Biophysical Society 62nd Annual Meeting | Program Guide

2434-Pos CID Travel Awardee CONTROL OF MEMBRANE PERMEABILITY VIA VOLTAGE REGULATED LYS- ENIN CHANNELS. Philip Belzeski , Sheenah Bryant, Nisha Shrestha, Daniel Prather, Samuel Kosydar, Daniel Fologea 2435-Pos Board B451 ACCESS RESISTANCE IN ATOMICALLY THIN NANOPORES. Subin Sahu , Michael P. Zwolak 2436-Pos Board B452 BACKBONE amIDE NITROGEN ATOMS ARE KEY DETERMINANTS OF INTER- ANION DISCRIMINATION IN CLCS. Lilia Leisle , Eva Fortea, Jason Galpin, Christopher Ahern, Alessio Accardi 2437-Pos Board B453 SIMULATING THE PERMEATION OF FOSFOMYCIN FROM THE EXTRACEL- LULAR SPACE TO THE SITE OF ACTION IN GRAM-NEGATIVE BACTERIA.  Vinaya Kumar Golla , Karunakar Reddy Pothula, Ulrich Kleinekathöfer 2438-Pos Board B454 UNITARY WATER CHANNEL PERMEABILITY AND ARRHENIUS ACTIVATION ENERGY ARE INTRICATELY LINKED. Andreas Horner, Peter Pohl 2439-Pos Board B455 RECTIFYING IONIC CURRENT IN CONICAL SUB-MICROPORES FUNCTION- ALIZED WITH POLY-L-LYSINE. Chih-Yuan Lin , Cody Combs, Zuzanna S. Siwy 2440-Pos Board B456 PHOSPHATIDYLINOSITOL-(4,5)-BISPHOSPHATE IS A NECESSARY COFAC- TOR FOR TMEM16F ION CHANNEL ACTIVITIES. Wenlei Ye , Tina W. Han, Layla M. Nassar, Mario Zubia, Yuh Nung Jan, Lily Y. Jan 2441-Pos Board B457 COOPERATIVITY AND FLEXIBLE DOMAINS PARTICIPATION IN PIP AQUA- PORIN GATING. Karina Alleva , Florencia Scochera, Agustina Canessa Fortuna, CINTIA JOZEFKOWICZ, Victoria Vitali, Gerardo Zerbetto de Palma, Gabriela Soto, F. Luis Gonzalez Flecha 2442-Pos Board B458 A NEWMETHOD TO STUDY THE LYSOMAL ELECTRICAL ACTIVITY IN LIVING CELLS. Ella Matamala , Cristian Castillo, Kirill Kiselyov, Sebastian Brauchi 2443-Pos Board B459 CRYO ELECTRON TOMOGRAPHY AND REACTION-DIFFUSION SIMULA- TIONS REVEAL A MOLECULAR AND EVOLUTIONARY BASIS FOR CHARGED ARCHAEAL SURFACE LAYER PROTEINS. Po-Nan Li , Jonathan R. Herrmann, Frederic PB Poitevin, Rasika Ramdasi, Bradley B. Tolar, John Barger, David Stahl, Grant Jensen, Soichi Wakatsuki, Henry van den Bedem 2444-Pos Board B460 SUBUNIT DEPENDENT REGULATION OF LRRC8 MEDIATED VRAC CUR- RENTS BY OXIDATION. Antonella Gradogna, Paola Gavazzo, Anna Boccac- cio, Michael Pusch 2445-Pos Board B461 SUBTLE MODIFICATIONS OF THE PANNEXIN-1 N-TERMINUS RESULTS IN ALTERED CHANNEL ACTIVITY. Kevin Michalski , Toshi Kawate Cardiac Muscle Mechanics and Structure II (Boards B462–B480) 2446-Pos Board B462 PATHOGENIC MECHANISMS OF THE CARDIOMYOPATHY-ASSOCIATED ALPHA-TROPOMYOSIN VARIANT E192K AS REVEALED BY MULTISCALE MODELING AND EXPERIMENTS. Lorenzo R. Sewanan , Jinkyu Park, Michael J. Rynkiewicz, Stephen M. Hollenberg, Nikolaos Papoutsidakis, Daniel L. Jacoby, Jeffrey R. Moore, William Lehman, Yibing Qyang, Stuart G. Campbell Board B450

2421-Pos Board B437 NOVEL CNG CHANNELOPATHY MODEL GENERATED USING CRISPR/CAS9- MEDIATED GENOME EDITING IN ZEBRAFISH. Michael D. Varnum , Peter C. Meighan, Samuel S. Hunter, Lindsey M. Morey, Tshering Sherpa 2422-Pos Board B438 ACIDOSIS PROLONGS APD IN OPTICALLY MAPPED ADULT ZEBRAFISH WHOLE HEARTS AS A RESULT OF HERG CHANNEL BLOCK. Yu P. Shi , Cher- lene Chang, Marvin Gunawan, Eric Lin, Sanam Shafaattalab, Glen Tibbits, Tom Claydon 2423-Pos Board B439 STREPTOMYCIN ENTRY IS MEDIATED BY THE MECHANOSENSITIVE CHAN- NEL MSCCG OF CORYNEBACTERIUM GLUTAMICUM . Yoshitaka Nakaya- ma , Kosuke Komazawa, Navid Bavi, Kazuhiro Nobata, Ken-ichi Hashimoto, Hisashi Kawasaki, Boris Martinac Other Channels II (Boards B440–B461) 2424-Pos Board B440 UNDERSTANDING THE STRUCTURE AND FUNCTION OF THE DCAP CHANNEL FROM ACINETOBACTER BAUMANNII USING MD SIMULA- TIONS.  Jigneshkumar D. Prajapati , Satya Prathyusha Bhamidimarri, Michael Zahn, Dirk Bumann, Mathias Winterhalter, Bert van den Berg, Ulrich Kleinekathöfer 2425-Pos Board B441 GLIAL CHANNELS AND TRANSPORTERS THAT MEDIATE EXCRETION OF K + IN THE MICROENVIRONMENT BETWEEN GLIA AND NEURONS SHAPE NEURONAL OUTPUT IN C. ELEGANS . Christina Johnson , Ying Wang, Lu Han, Laura Bianchi 2426-Pos Board B442 THE HUMAN ERYTHROCYTE MECHANO-ACTIVATED K + CHANNEL A (HEMKCA): EFFECT OF BA 2+ ON BURST ACTIVITY. Yeimar Rortillo, Alejandro Mata, Jesus G. Romero 2427-Pos Board B443 THE ANNEXIN V TRANSMEMBRANE CHANNEL. Yichih Lin , Atsushi Miyagi, Simon Scheuring 2428-Pos Board B444 GAIN-OF-FUNCTION OF TMEM16E/ANO5 SCRAMBLING ACTIVITY CAUSED BY A MUTATION ASSOCIATED WITH THE BONE GENETIC DISEASE GNATHODIAPHYSEAL DYSPLASIA. Eleonora Di Zanni, Antonella Gradogna, Joachim Scholz-Starke, Anna Boccaccio 2429-Pos Board B445 SPHINGOSINE-1-PHOSPHATE-INDUCED ATP SECRETION IN MICROGLIA IS MEDIATED BY LRRC8 PROTEINS OF VOLUME-REGULATED ANION CHAN- NELS. Philipp Burow, Manuela Klapperstück, Fritz Markwardt 2430-Pos Board B446 ZINC INHIBITION OF AN INSECT VOLTAGE-GATED PROTON CHANNEL. Gus- tavo Chaves, Stefanie Bungert-Plümke, Arne Franzen, Boris Musset 2431-Pos Board B447 OPTICALLY ACTIVE, SELF-ASSEMBLED SOLID-STATE NANOPORES FOR SINGLE PARTICLE DETECTION. Andreas Schlegel , Paul V. Gwozdz, Christian Heyn, August Dorn, André Drews, Wolfgang Hansen, Robert H. Blick 2432-Pos Board B448 EXP2 IN THE ROLE OF THE SMALL MOLECULE PORE IN THE PARASITOPH- OROUS VACUOLE MEMBRANE OF PLASMODIUM FALCIPARUM . Matthias Garten , Josh R. Beck, Svetlana Glushakova, Armiyaw S. Nasamu, Jacquin C. Niles, Daniel E. Goldberg, Joshua Zimmerberg 2433-Pos Board B449 UNITARY WATER PERMEABILITY MEASUREMENTS VIA LIPID VESICLE SYSTEMS. Andreas Horner , Thomas Barta, Christof Hannesschläger, Peter Pohl

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