Biophysical Society 62nd Annual Meeting | Program Guide

2460-Pos CID Travel Awardee CARDIAC LIGHT CHAIN amYLOIDOSIS, UNDERSTANDING THE IMPLICA- TIONS OF CELLULAR TOXICITY IN A 3D MODEL. Keely Redhage , Chris Dick, Yi Lin, Marta Marin-Argany, Angela Williams, John S. Wall, Marina Ramirez-Alvarado 2461-Pos Board B477 SOLVING FOR THE RATE OF DIFFUSION IN CARDIAC TRANSVERSE TUBULES FROM FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING EXPERIMENTS. Cherrie HT Kong, Clive H. Orchard, Mark B. Cannell 2462-Pos Board B478 QUANTIFYING THE CONTRIBUTION OF CARDIOMYOCYTE METABOLIC DYSFUNCTION TO THE HEART MECHANICAL FUNCTION. Rachel Lopez , Xin Gao, Francoise Van den Bergh, Santosh Dasika, Daniel Beard 2463-Pos Board B479 COMPUTATIONAL AND EXPERIMENTAL INVESTIGATION OF TROPOMYO- SIN D230N AND S215L MUTATION SPECIFIC CORRELATES TO DISEASE.  Andrea Deranek , Anthony Baldo, Melissa L. Lynn, Mark T. McConnell, Michael R. Williams, Steven D. Schwartz, Jil C. Tardiff 2464-Pos Board B480 QUANTIFYING NUCLEAR REMODELING IN HEART FAILURE. Logan Bailey , Danny Smyl, Sven Bossuyt, Julie Bossuyt Cardiac Muscle Regulation II (Boards B481–B496) 2465-Pos Board B481 DEFINING A UNIFYING MECHANISM FOR SELECT CARIOMYOPATHY- LINKED VARIANTS OF DESMOPLAKIN. Heather R. Manring , Ronald Ng, Taylor Albertelli, Prameela Jyothi Bobbili, Olivia Carter, Tyler Stevens, Daniel Jacoby, Paul M. L. Janssen, Ahmet Kilic, Nathan Wright, Stuart Campbell, Maegen A. Ackermann 2466-Pos Board B482 TNNT2 RESTRICTIVE AND HYPERTROPHIC CARDIOMYOPATHY MUTATIONS DEPRESS THE INHIBITORY PROPERTIES OF THE TROPONIN-T1 FRAGMENT, IN VITRO . Aditi Madan , Sineej Madathil, William Schmidt, Larry S. Tobac- man, Anthony Cammarato 2467-Pos Board B483 DEFINING A NOVEL MECHANISMMEDIATING THE RATE OF HEART FAIL- URE PROGRESSION. Heather R. Manring , Prameela Jyothi Bobbili, Abigail Beer, Paul M. L. Janssen, Ahmet Kilic, Maegen A. Ackermann 2468-Pos Board B484 INFLUENCE OF CTN CA 2+ BINDING PROPERTIES AND COOPERATIVE MECHANISMS ON CARDIAC MUSCLE CONTRACTILE DYNAMICS. Srboljub M. Mijailovich , Djordje Nedic, Boban Stojanovic, Joseph D. Powers, Jen- nifer Davis, Michael A. Geeves, Michael Regnier 2469-Pos Board B485 CARDIAC MYOSIN STRUTURAL KINETICS ARE MODULATED BY MYK461. John Rohde, David D. Thomas, Joseph M. Muretta 2470-Pos Board B486 ALTERED SIGNALING PATHWAYS IN HEARTS OF amES DWARF MICE. Emily Eijansantos , Shuchita Tiwari, Aldrin Gomes 2471-Pos Board B487 TRIBUTYTIN INDUCES NEGATIVE INOTROPIC EFFECT, REDUCES CARDIAC SR CALCIUM CONTENT AND INCREASES CALCIUM SPARKS FREQUENCY IN CARDIOMYOCYTES.  Ivanita Stefanon , Cleydianne Luiza Vieira Pereira, Bruno Barcellos Jacobsen, Rogério Faustino Ribeiro Junior, Donald M. Bers Board B476

2447-Pos Board B463 NATIVE REDOX POSTTRANSLATIONAL MODIFICATIONS AS REGULA- TORS OF TITIN MECHANICAL PROPERTIES. Elías Herrero-Galán , Cristina Sánchez-González, Diana Velázquez-Carreras, Elena Bonzón-Kulichenko, Enrique Calvo, Jesús Vázquez, Jorge Alegre-Cebollada 2448-Pos Board B464 HIGH-RESOLUTION STRUCTURAL BASIS OF A DUAL TITIN/OBSCURIN COMPLEX WITH TWO WELL-SEPARATED SITES. Philipp Hornburg , Atsushi Fukuzawa, Mathias Gautel, Matthias Wilmanns 2449-Pos Board B465 Education Travel Awardee IMPACT OF DILATED CARDIOMYOPATHY MUTATION AND SMALL MOL- ECULE REGULATOR ON HUMAN BETA-CARDIAC MYOSIN. Wanjian Tang , William C. Unrath, Rohini Desetty, Christopher M. Yengo 2450-Pos Board B466 THE GIANT PROTEIN TITIN REGULATES THE LENGTH OF THE STRIATED MUSCLE THICK FILAMENT-TITIN RULES. Henk Granzier , Paola Tonino, Balazs Kiss, Joshua Strom, John Smith, Mei Methawasin, Justin Kolb 2451-Pos Board B467 SIMILAR EFFECTS OF HUMORAL OR MECHANICAL STRESS ON CELL-CELL CONTACTS IN CULTURED CARDIOMYOCYTES. Oliver Koldyka, Pragati Pandey, Thomas Iskratsch, Elisabeth Ehler 2452-Pos Board B468 MECHANOBIOLOGY OF MYOSIN MUTATIONS AND MYOFIBRIL REMODEL- ING IN IPSC-CARDIOMYOCYTES. Alison Schroer , Kristina Kooiker, Arjun Adhikari, Kathleen Ruppel, Daniel Bernstein, James Spudich, Beth Pruitt 2453-Pos Board B469 THE ROLE OF CTNT ISOFORM SWITCHING IN MODULATING SARCOMERIC CARDIOMYOPATHIES. Melissa L. Lynn , Teryn A. Holeman, Grace Benitez, Mark T. McConnell, Lauren Tal-Grinspan, Jil C. Tardiff 2454-Pos Board B470 DIFFERENCES IN MYOFILAMENT INTERACTIONS AND STRUCTURAL DYNAMICS BETWEEN MOUSE AND HUMAN CARDIAC MYOSIN-BINDING PROTEIN C. Thomas C. Bunch, Victoria C. Lepak, Brett A. Colson 2455-Pos Board B471 GENETICALLY ENGINEERED HUMAN STEM-CELL DERIVED CARDIOMYO- CYTES TO INVESTIGATE THE FUNCTION OF CRONOS TITIN. Rebecca Zaunbrecher , Kevin Beussman, Andrea Leonard, Marion von Frieling- Salewsky, Lil Pabon, Hans Reinecke, Xiulan Yang, Wolgang A. Linke, Nathan J. Sniadecki, Charles E. Murry, Michael Regnier 2456-Pos Board B472 ULTRASTRUCTURAL SURVEYS OF CARDIOMYOCYTES ISOLATED FROM FAILING HUMAN HEARTS. Patrick Robison , Christina Yingxian Chen, Matthew A. Caporizzo, Kenneth Bedi, Kenneth B. Margulies, Benjamin L. Prosser 2457-Pos Board B473 UNIQUE STRUCTURAL AND FUNCTIONAL EFFECTS OF ALPHA-TROPOMY- OSIN MUTATIONS IN HCM AND DCM. Teryn A. Holeman , Melissa L. Lynn, Jil C. Tardiff 2458-Pos Board B474 NEONATAL PERMEABILITY TRANSITION PORE CLOSURE IS ASSOCIATED WITH INCREASED CARDIAC FUNCTION. Ryan E. Alanzalon , George A. Porter 2459-Pos Board B475 EFFECT OF TRUNCATED MUTATIONS IN THE TITIN GENE ON CARDIAC FUNCTION. Petr G. Vikhorev , amy Li, Sean Lal, Cristobal G. dos Remedios, Steven B. Marston

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