Biophysical Society 62nd Annual Meeting | Program Guide

2513-Pos Board B529 A FLUID MEMBRANE ENHANCES THE VELOCITY OF CARGO TRANSPORT BY SMALL TEAMS OF KINESIN-1. Qiaochu Li , Kuo-Fu Tseng, Stephen J. King, Weihong Qiu, Jing Xu 2514-Pos Board B530 KINESIN ROTATES UNIDIRECTIONALLY WHILE WALKING ON MICROTU- BULES TRANSFERRING TORQUE ONTO CARGO. Avin Ramaiya, Basudev Roy, Michael Bugiel, Erik Schäffer 2515-Pos Board B531 NEW STRUCTURE AND ENERGY CYCLES OF KINESIN DIMERS WALKING ON MICROTUBULES REVEALED FROMMOLECULAR SIMULATIONS. Allicia Pan, Allen Pan, Bernard R. Brooks, Xiongwu Wu 2516-Pos Board B532 MICROTUBULES CAN INFLUENCE KINESIN’S FORESTEP-BACKSTEP DECI- SION. Algirdas Toleikis , Nicholas J. Carter, Robert A. Cross 2517-Pos Board B533 STRUCTURAL CHARACTERIZATION OF THE ATP-WAITING AND POST-HY- DROLYSIS STATES OF DIMERIC KINESIN-1 USING CRYO-EM. Hyo Keun Cha , Xueqi Liu, Garrett Debs, Daifei Liu, Charles Sindelar 2518-Pos Board B534 ENHANCED STABILITY OF KINESIN-1 AS A FUNCTION OF TEMPERA- TURE. Katelyn J. Chase , Florence Doval, Michael Vershinin 2519-Pos Board B535 ATOMIC FORCE SIMULATIONS REVEAL THAT THE LEADING HEAD OF KI- NESIN DIMERS GENERATES THE CARGO MOVING FORCE. Alicia Pan , Allen Pan, Xiongwu Wu 2520-Pos Board B536 COMPUTATIONAL AND BIOCHEMICAL ANALYSIS OF DISEASE-CAUSING MUTATIONS AT THE KINESIN-MICROTUBULE INTERFACE. Chelsea Kelland, Lauren Thornton, Hana Alkhafaf, Madhusoodanan Mottamal, Thomas M. Board B537 KINESIN-2 MOTORS ADAPT THEIR STEPPING BEHAVIOR FOR PROCESSIVE TRANSPORT ON AXONEMES AND MICROTUBULES. Willi L. Stepp , Georg Merck, Felix Mueller-Planitz, Zeynep Ökten 2522-Pos Board B538 NOVEL KINESIN-3 MOTOR BEHAVIOR IS REGULATED BY TAU. Dominique V. Lessard , Christopher L. Berger 2523-Pos Board B539 MORELLOFLAVONE AS A NOVEL INHIBITOR FOR KINESIN EG5. Tomisin Happy Ogunwa, Kenichi Taii, Shuya Yano, Kei Sadakane, Yuka Kawata, Shinsaku Maruta, Takayuki Miyanishi 2524-Pos Board B540 NOVEL PHOTOCHROMIC POTENT INHIBITOR OF MITOTIC KINESIN EG5 COMPOSED OF SPIROPYRAN DERIVATIVES. Kei Sadakane, Kenichi Taii, Shinsaku Maruta 2525-Pos Board B541 PHOTO-REGULATION OF MITOTIC KINESIN EG5 USING NOVEL PHOTO- CHROMIC INHIBITOR THAT FORMS THREE ISOMERIZATION STATES.  Islam M.D. Alrazi , Kei Sadakane, Shinsaku Maruta 2526-Pos Board B542 TWO OPPOSING MODES OF CYTOPLASMIC DYNEIN REGULATION BY LIS1. ZawM. Htet , Morgan E. DeSantis, Michael A. Cianfrocco, Phuoc T. Tran, Andres E. Leschziner, Samara L. Reck-Peterson Huckaba 2521-Pos

2500-Pos Education Travel Awardee MECHANISM OF MICROTUBULE STABILIZATION BY KINESIN-5. Geng-Yuan Chen , Ana B. Asenjo, Hernando J. Sosa, William O. Hancock 2501-Pos Board B517 MOLECULAR REQUIREMENTS FOR THE TRANSITION FROM LATERAL TO END-ON MICROTUBULE BINDING AND DYNAMIC COUPLING. Ekaterina L. Grishchuk , Manas Chakraborty, Anatoly V. Zaytsev, Maxim Godzi, Ekat- erina Tarasovetc, Ana C. Figueiredo, Fazly I. Ataullakhanov 2502-Pos Board B518 MICROTUBULE STRUCTURAL STATE RECOGNITION BY END BINDING PROTEIN 1. Taylor A. Reid , Courtney Coombes, Holly Goodson, Melissa K. Gardner 2503-Pos Board B519 STRUCTURAL MODEL FOR PREFERENTIAL MICROTUBULE MINUS END BINDING BY CAMSAP CKK DOMAINS. Joseph Atherton, , Kai Jiang, Marcel Stangier, Yanzhang Luo, Shasha Hua, Klaartje Houben, Guido Scarabelli, Agnel Joseph, Anthony Roberts, Barry Grant, Maya Topf, Michel Stein- metz, Marc Baldus, Anna Akhmanova, Carolyn Moores 2504-Pos Board B520 STRUCTURAL CHANGES IN TAU UNDERLIE STATIC AND DIFFUSIVE BIND- ING TO THE MICROTUBULE LATTICE. Alisa Cario , Jamie Stern, Christopher Board B521 THE EFFECT OF SITE-SPECIFIC TAU MUTATIONS ON MICROTUBULE BUNDLE STRUCTURES. Christine Tchounwou 2506-Pos Board B522 Education Travel Awardee ROLE OF ANTI-TAU ANTIBODIES ON MICROTUBULE POLYMERIZATION AND STABILITY.  Iva Ziu , Matthew Imhof, Saba Anwar, Sanela Martic* 2507-Pos Board B523 N-TERMINAL INSERTS IMPACT THE GLOBAL CONFORMATION OF TAU AND THE TAU-TUBULIN COMPLEX. Kristen McKibben , Elizabeth Rhoades 2508-Pos Board B524 DISPARATE ROLES OF ALPHA AND BETA CTTS IN MICROTUBULE SEVER- ING. Rohith Anand Varikoti 2509-Pos Board B525 MODULATION OF MACROMOLECULAR BIOLOGICAL STRUCTURES BY DIVALENT IONS. Bretton J. Fletcher , Chaeyeon Song, Phillip Kohl, Peter Chung, Herbert P. Miller, Youli Li, Myung Chul Choi, Leslie Wilson, S.C. Feinstein, Cyrus R. Safinya 2510-Pos Board B526 DETERMINING THE IMPORTANT PARAMETERS IN BIOLOGICAL MODELS USING NUMERICAL PARAMETER COMPRESSION. Chieh-Ting Hsu , Gary Brouhard, Paul Francois Board B516 L. Berger 2505-Pos

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Kinesins, Dyneins, and Other Microtubule-based Motors I (Boards B527–B545)

2511-Pos Board B527 BIASED BINDING MECHANISM ALONE CAN EXPLAIN THE PREFERENTIAL FORWARD STEPPING OF KINESIN-1. Kohei Matsuzaki, Hiroshi Isojima, Hiroyuki Noji, Michio Tomishige 2512-Pos Board B528 NONEQUILIBRIUM ENERGETICS OF SINGLE MOLECULE MOTOR, KINE- SIN-1. Takayuki Ariga , Michio Tomishige, Daisuke Mizuno

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