Biophysical Society 62nd Annual Meeting | Program Guide

207-Plat 4:00 pm STAC PROTEINS ASSOCIATE WITH THE DOMAIN OF THE CA V 1.1 II-III LOOP CRITICAL FOR EC COUPLING.  Alexander Polster , Benjamin R. Nelson, Symeon Papadopoulos, Eric N. Olson, Kurt G. Beam 208-Plat 4:15 pm STRUCTURAL INSIGHTS INTO THE STAC ADAPTOR PROTEIN AND VOLTAGE-GATED CALCIUM CHANNEL INTERACTION.  Siobhan Wong King Yuen , Marta Campiglio, Ching-Chieh Tung, Bernhard Flucher, Filip Van 4:30 pm DE NOVO RECONSTITUTION OF SKELETAL MUSCLE VOLTAGE-INDUCED CALCIUM RELEASE.  Stefano Perni , Manuela Lavorato, Kurt G. Beam 210-Plat 4:45 pm EVERY ACTION POTENTIAL ACTIVATES STORE-OPERATED CA 2+ ENTRY IN SKELETAL MUSCLE.  Xaver Koenig, Bradley S. Launikonis 211-Plat 5:00 pm ROLE OF THE CACC CHANNEL ANO1 IN ELECTROMECHANICAL COUPLING OF MURINE PULMONARY ARTERY SMOOTH MUSCLE.  Katie Mayne, Michael D. Young, Nathan Grainger, Julius C. Baeck, Kenton M. Sanders, Sean M. Ward, Iain A. Greenwood, Simon A. Bulley, Jonathan H. Jaggar, Normand Leblanc 212-Plat 5:15 pm EXPRESSION OF ORAI1 RESTORES NORMAL SARCOPLASMIC CALCIUM RELEASE IN CMPT MICE. Mónika T. Sztretye , Péter Szentesi, László Cser- noch, Beatrix Dienes 213-Plat 5:30 pm FIBROBLAST-MEDIATED ATRIAL MECHANICAL DYSFUNCTION IN HFPEF AND HYPERTENSIVE HEART DISEASE.  David Bode , Rafael Doerr, Diana Lindner, Michael Schwarzl, Dirk Westermann, Uwe Primessnig, Burkert Pieske, Frank R. Heinzel, Felix Hohendanner 214-Plat 5:45 pm SURFACE MECHANOSENSORS AND THE FUNDAMENTAL CONUNDRUM OF HOMEOMETRIC REGULATION.  Rafael Shimkunas, Zhong Jian, Zana Coulibaly, Ye Chen-Izu, Leighton T. Izu Platform Computational Methods and Bioinformatics 4:00 pm–6:00 pm, Esplanade, Room 155 Co-Chairs Mary Maleckar, Allen Institute for Cell Science Karel Berka, Palacký University, Czech Republic 215-Plat 4:00 pm A DIMENSION REDUCTION METHOD FOR CRYO-EM IMAGE ANALYSIS.  4:15 pm IDENTIFYING METASTABLE STATES OF PROTEIN FOLDING WITH DEEP CLUSTERING TECHNIQUES.  Debsindhu Bhowmik , Arvind Ramanathan 217-Plat 4:30 pm EFFECTIVELY DETECT METASTABLE STATES OF PROTEINS BY NON-EQUI- LIBRIUM SIMULATIONS.  Xin Zhou 218-Plat 4:45 pm SEEKR: SIMULATION ENABLED ESTIMATION OF KINETIC RATES, A MULTI- SCALE APPROACH FOR THE CALCULATION OF PROTEIN-LIGAND ASSOCIA- TION AND DISSOCIATION KINETICS.  Benjamin R. Jagger , Lane W. Votapka, Rommie E. amaro 219-Plat 5:00 pm ACCURATE PREDICTION OF PROTEIN-LIGAND BINDING BY COMBINED MOLECULAR DYNAMICS-BASED DOCKING AND QM/MMMETHODS.  Iris Antes , Antoine Marion, Chen Zheng, Okke Melse Petegem 209-Plat I-Ping Tu 216-Plat

220-Plat 5:15 pm A NOVEL FINITE VOLUME METHOD FOR DIFFUSION EQUATION COUPLED WITH CELL SURFACE REACTION. Myles Kim 221-Plat 5:30 pm STUDYING STEM CELL ORGANIZATION USING “LABEL-FREE” METHODS AND A NOVEL GENERATIVE ADVERSARIAL MODEL.  Gregory Johnson, Rory Donovan-Maiye, Chek Ounkomol, Mary M. Maleckar 222-Plat 5:45 pm IN SILICO IDENTIFICATION OF RESCUE SITES BY DOUBLE FORCE SCAN- NING. Matteo Tiberti, Alessandro Pandini , Franca Fraternali, Arianna Fornili Platform Energy Transducing Complexes and Mitochondria in Cell Life and Death 4:00 pm–6:00 pm, Esplanade, Room 156 Co-Chairs Anjali Pandit, Leiden University,The Netherlands Elena Pohl, University of Veterinary Medicine Vienna, Austria 223-Plat 4:00 pm CRYO-EM STRUCTURE OF ALTERNATIVE COMPLEX III/ AA 3 CYTOCHROME OXIDASE SUPERCOMPLEX FROM FLAVOBACTERIUM JOHNSONIAE .  Chang Sun , Padmaja Venkatakrishnan, Samir Benlekbir, Yuhang Wang, John Rubinstein, Robert B. Gennis, Emad Takjhorshid 224-Plat 4:15 pm MODULATION OF THE MITOCHONDRIAL POTASSIUM CHANNEL ACTIVITY BY INFRARED LIGHT.  Adam Szewczyk , Piotr Bednarczyk 225-Plat 4:30 pm STRUCTURAL DYNAMICS OF LIGHT-HARVESTING COMPLEX II IN NATIVE THYLAKOID MEMBRANES DETECTED BY SOLID-STATE NMR.  Anjali Pandit 226-Plat 4:45 pm STRUCTURE OF PHOTOSYSTEM I–INTERPLAY BETWEEN ROBASTNESS AND COMPLEXITY.  Nathan Nelson , Ido Caspy, Daniel Klaiman 227-Plat 5:00 pm HIGH-RESOLUTION SUB-ENSEMBLE OPTICAL SPECTROSCOPY STUDY OF PROTEIN DYNAMICS AND ENERGY TRANSFER IN PIGMENT-PROTEIN COMPLEXES.  Valter Zazubovits 228-Plat 5:15 pm Education Travel Awardee ROLE OF TYROSINE PHOSPHORYLATION OF MITOCHONDRIAL CALCIUM UNIPORTER IN REGULATING MITOCHONDRIAL CALCIUM HOMEOSTASIS.  Jessica L. Cao , Stephanie Adaniya, amy K. Landi, Dong Qin Yang, Bong Sook Jhun, Shey-Shing Sheu, Jin O-Uchi 229-Plat 5:30 pm UCP3: NEW INSIGHTS IN TISSUE DISTRIBUTION AND (TRANSPORT) FUNC- TION.  Elena E. Pohl , Gabriel Macher, Karolina Hilse 230-Plat 5:45 pm MITOCHONDRIAL DEFECTS IN PRIMARY OSTEOCYTES DERIVED FROM AN ALS MOUSE MODEL.  Huan Wang, Jianxun Yi, Xinyang Xu, Xuejun Li, Yajuan Xiao, Jingsong Zhou Exhibitor Presentation Molecular Devices LLC 4:30 pm–6:00 pm, Exhibit Hall, Room 6 Supercharge Your Patch-Clamp Data Acquisition and Analysis with the NEW pCLAMP 11 Software The patch-clamp technique remains the best method for evaluating ion channel physiology, and since 1983, Axon Instruments has been the gold standard in patch-clamp equipment. Axon Instruments continues to push the envelope with new innovations with best-in-class systems and software.

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