Biophysical Society 62nd Annual Meeting | Program Guide

399-Pos Board B169 IDENTIFICATION OF A SPECIFIC RESIDUE SIDE CHAIN CONTROLLING THE SELF-ASSEMBLY AND CYTOTOXICITY OF ISLET amYLOID POLYPEP- TIDE. Phuong Trang Nguyen , Elizabeth Godin, Ximena Zottig, Steve Bourgault 400-Pos Board B170 EXOSOMES FROM HUMAN PANCREATIC ISLETS SUPPRESS IAPP amYLOID FORMATION. Pernilla Wittung-Stafshede 401-Pos Board B171 HUMAN ISLET amYLOID POLYPEPTIDE: IDENTIFYING EARLY-STAGE AGGRE- GATION MECHANISMS THROUGH MOLECULAR SIMULATION.  Ashley Z. Guo , Juan J. de Pablo 402-Pos Board B172 AMYLIN (HIAPP) AGGREGATES ON THE MEMBRANE. Simli Dey , Anoop Rawat, Bappaditya Chandra, Barun Kumar Maity, Perunthiruthy K. Madhu, Sudipta Maiti 403-Pos Board B173 STRUCTURAL ANALYSES OF A LINKER REGION OF THE amYLOID PRECUR- SOR PROTEIN. Mizuho Imamura , Shingo Kanemura, Masaki Okumura, Shigeru Shimamoto, Yuji Hidaka 404-Pos Board B174 HSP70 DELAYS amYLOID AGGREGATION OF amYLIN BY INHIBITING PRIMARY NUCLEATION. Neeraja Chilukoti, Bankanidhi Sahoo, Mithun Maddheshiya, Kanchan Garai 405-Pos Board B175 CONFORMATIONAL CHANGES AND FLEXIBILITY FOR ARKA BINDING TO ABP1-SH3. Kristina Foley , Robyn Stix, Gabriella Gerlach, K. Aurelia Ball 406-Pos Board B176 CONFORMATIONAL CHANGES OF ARKA12. Robyn Stix , Kristina Foley, Gabriella Gerlach, K. Aurelia Ball 407-Pos Board B177 INITIAL BINDING INTERACTION BETWEEN ARKA AND ABP1SH3.  Gabriella Gerlach , Kristina Foley, Robyn Stix, Lia Ball 408-Pos Board B178 INTRINSICALLY DISORDERED PROTEINS LINK ALTERNATIVE SPLICING AND POST-TRANSLATIONAL MODIFICATIONS TO COMPLEX CELL SIGNALING AND REULATION. Jinhong Zhou, Suwen Zhao, A. K. Dunker 409-Pos Board B179 LARGE-SCALE ANALYSIS OF THE EVOLUTION OF FUNCTIONS MEDIATED BY INTRINSICALLY DISORDERED REGIONS. Mary O. G. Richardson , Alex S. Holehouse, Iris Langstein, Philipp Korber, Rohit V. Pappu 410-Pos Board B180 CONTROLLED LIQUID-LIQUID PHASE SEPERATION OF RECOMBINANT OLEOSIN. Ellen H. Reed , Daniel A. Hammer 411-Pos Board B181 CONTROLLABLE PROTEIN PHASE SEPARATION AND MODULAR RECRUIT- MENT TO INVESTIGATE BIOCHEMICAL COMPARTMENTALIZATION IN MEMBRANELESS ORGANELLES. Benjamin S. Schuster , Matthew C. Good, Daniel A. Hammer 412-Pos Board B182 MICROSCOPIC OBSERVATIONS OF PROTEIN BROWNIAN MOTIONS IN SUPERSATURATED SOLUTIONS. Kazuki Yoshimura , Msahiro Kuramochi, Yuji C. Sasaki 413-Pos Board B183 PROTEIN INTERACTIONS CONTROL DYNAMICS OF LIQUID COMPART- MENTS. Tyler S. Harmon , Frank Jülicher, Anthony A. Hyman

414-Pos Board B184 QUANTITATIVE MEASUREMENT OF STABILITY AND HETEROGENEITY OF PROTEIN amYLOIDS USING DISAGGREGATION BY CHEMICAL DENATUR- ANTS. Timir Baran Sil , Bankanidhi Sahoo, Subhas Chandra Bera, Kanchan Garai 415-Pos Board B185 THERMODYNAMIC AND HYDRODYNAMIC PROPERTIES OF A DOXORU- BICIN LABELED ELP-DRUG CARRIER. Valeria Zai-Rose , Wolfgang Kramer, Reid Bishop, John J. Correia DNA Replication, Recombination, and Repair (Boards B186–B209) 416-Pos Board B186 QUATERNARY INTERACTIONS AND DNA TWIST MODULATE THE COOP- ERATIVE BINDING OF AGT. Michael G. Fried , Manana Melikishvili 417-Pos Board B187 CID Travel Awardee CHARACTERIZING THE ENHANCED NANOSCALE TRANSLOCATION PROPERTIES OF HUNG2 FACILITATED BY ITS DISORDERED N-TERMINAL DOMAIN IN VITRO AND IN HUMAN CELLS. Gaddiel Rodriguez , Alexan- dre Esadze, Brian P. Weiser, Joseph D. Schonhoft, Philip A. Cole, James T. Stivers 418-Pos Board B188 DNA SYNTHESIS DETERMINES THE BINDING MODE OF THE HUMAN MITOCHONDRIAL SSB PROTEIN. Fernando Cerron, Jose Morin, Javier Jarillo, Elena Beltrán-Heredia, Grzegorz Ciesielski, Francisco Cao, Laurie S. Kaguni, Borja Ibarra 419-Pos Board B189 A NOVEL DNA REPAIR MECHANISM FOR THE PROCESSING OF LOW-LEVEL UV-INDUCED DAMAGE IN BACTERIA. Luke Springall, Craig Hughes, Mi- chelle Simons, Stavros Azinas, Bennett Van Houten, Neil Kad 420-Pos Board B190 IPMK AND PTEN REGULATE NUCLEAR PHOSPHOINOSITIDE-DEPENDENT ATR SIGNALING UPON DNA DAMAGE. Yu-Hsiu Wang , Anushya Hariharan, Giulia Bastianello, Yusuke Toyama, G. V. Shivashankar, Marco Foiani, Michael P. Sheetz 421-Pos Board B191 COORDINATED ACTIONS OF FOUR ATPASE SITES ON UVRA 2 DURING INITIATION OF NUCLEOTIDE EXCISION REPAIR. Brandon C. Case , Silas Hartley, David Jeruzalmi, Manju M. Hingorani 422-Pos Board B192 FUNCTION OF THE INTRINSICALLY DISORDERED N-TERMINUS OF URACIL DNA GLYCOSYLASE. Brian P. Weiser , Gaddiel Rodriguez, Alexandre Es- adze, Philip A. Cole, James T. Stivers 423-Pos Board B193 THE 5’ NUCLEASE DOMAIN OF DNA POLYMERASE I MEDIATES A NOVEL DNA TRANSFER PATHWAY DURING PROOFREADING. Raymond Pauszek , Rajan Lamichhane, Arishma Rajkarnikar Singh, Edwin van der Schans, David Millar 424-Pos Board B194 DIRECT OBSERVATION OF MUTYH AND THE CANCER-ASSOCIATED Y150C VARIANT BINDING TO OG:A MISMATCHES AT THE SINGLE MOLECULE LEV- EL. Shane R. Nelson , Andrea J. Lee, Scott D. Kathe, Thomas S. Hilzinger, April M. Averill, Susan S. Wallace, David M. Warshaw 425-Pos Board B195 FLUORESCENCE LIFETIME OF NADH REVEALS PARP-DEPENDENT IN- CREASE OF OXIDATIVE PHOSPHORYLATION CRITICAL FOR CELL SUR- VIVAL. Michael M. Murata , Xiangduo Kong, Kyoko Yokomori, Michelle A. Digman

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