Biophysical Society 62nd Annual Meeting | Program Guide

Ligand-gated Channels I (Boards B398–B425)

615-Pos

Board B385 7.1 BY NA V

Β1 SUBUNIT. Elisa Carrillo-Flores,

MODULATION OF K V Carlos A. Villalba-Galea 616-Pos

F R I D A Y

S U N D A Y

628-Pos Board B398 ACTIVATION AND DESENSITIZATION MECHANISM OF amPA RECEPTOR- TARP COMPLEX BY CRYO-EM. Shanshuang Chen, Yan Zhao , Yuhang Wang, Mrinal Shekhar, Emad Tajkhorshid, Eric Gouaux 630-Pos Board B400 QUANTIFYING KINETIC TRANSITIONS BETWEEN NMDA RECEPTOR GAT- ING MODES. Gary J. Iacobucci , Gabriela K. Popescu 629-Pos Board B399 SINGLE MOLECULE FRET STUDIES INTO THE EFFECTS OF SODIUM ON KAINATE RECEPTOR DYNAMICS. Douglas Litwin , Sana Shaikh, Vladimir Berka, Vasanthi Jayaraman 631-Pos Board B401 EFFECTS OF T686A MUTATION ON THE STRUCTURAL STABILITY OF THE amPA RECEPTOR LIGAND-BINDING DOMAIN. Hiraku Oshima , Suyong Re, Masayoshi Sakakura, Hideo Takahashi, Yuji Sugita 632-Pos Board B402 SUBUNIT INDEPENDENCE IN amPA TYPE GLUTAMATE RECEPTORS.  Jelena Baranovic , Andrew J. R. Plested 633-Pos Board B403 SINGLE-CHANNEL STUDY OF amPA RECEPTORS RESTRAINED BY AN INTER- SUBUNIT ZINC BRIDGE. Sebastian Opfermann , Jelena Baranovic, Andrew J. R. Plested 634-Pos Board B404 FUNCTIONAL VALIDATION OF HETEROMERIC KAINATE RECEPTOR MOD- ELS. Teresa Paramo, Patricia MGE Brown, Maria Musgaard, Derek Bowie, Philip Biggin 635-Pos Board B405 ASSEMBLY OF KAINATE AND amPA RECEPTORS. Mark L. Mayer , Huaying Zhao, Suvendu Lomash, Sagar Chittori, Carla Glasser, Peter Schuck 636-Pos Board B406 MEMBRANE LIPID COMPOSITIONS CONTROL DYE-PERMEABLE PORE OF THE P2X7 RECEPTOR. Akira Karasawa , Kevin Michalski, Polina Mikhelzon, Toshimitsu Kawate 637-Pos Board B407 CHARACTERIZATION OF HEARING LOSS-RELATED MUTATIONS IN ATP- ACTIVATED ION CHANNELS. Benjamin I. George , Mufeng Li, Kenton J. Swartz 638-Pos Board B408 MAGNESIUMMODULATION OF P2X RECEPTOR CHANNELS. Mufeng Li , Shai D. Silberberg, Kenton J. Swartz 639-Pos Board B409 ROLE OF THE LEFT FLIPPER DOMAIN IN THE HOMOTRIMERIC ASSEMBLY AND FUNCTION OF P2X RECEPTORS. Angela Hein , Achim Kless, Ralf Haus- mann, Fritz Markwardt, Günther Schmalzing 640-Pos Board B410 CONFOCAL MICROSCOPY OF SKATE ELECTRORECEPTORS: FLUORESCENT ANTIBODIES USED TO LOCALIZE CAV1.3 AND BK CHANNELS.  William T. Clusin 641-Pos Board B411 CRYSTAL STRUCTURE OF A MYCOBACTERIAL RCK DOMAIN. Alexandre G. Vouga , Katia K. Matychak, Michael E. Rockman, Sebastian Garcia, Sebas- tian Brauchi, Brad S. Rothberg

Board B386 Education Travel Awardee COMPREHENSIVE ASSESSMENT OF DISEASE MUTANT FORMS OF THE HUMAN KCNQ1 POTASSIUM CHANNEL. Hui Huang , Georg Kuenze, Jarrod Smith, Keenan Taylor, amanda Duran, Jens Meiler, Carlos Vanoye, Alfred George, Charles Sanders 617-Pos Board B387 A NON-CANONICAL VSD-PORE COUPLING IS RESPONSIBLE FOR THE AO STATE OF KCNQ1 CHANNELS. Panpan Hou 618-Pos Board B388 PROPERTIES OF POLYUNSATURATED FATTY ACID TAIL INFLUENCE AFFIN- ITY FOR IKS CHANNEL. Briana Watkins , Sara Liin, Peter Larsson 619-Pos Board B389 PROBING THE MOLECULAR MECHANISM OF POLYUNSATURATED FATTY ACID MODULATION OF THE I KS CHANNEL. Sammy Yazdi , Sara Liin 620-Pos Board B390 COMBINING POPULATION WHOLE EXOME SEQUENCING AND FUNCTION- AL ANALYSIS TO DETECT LQT1. Cassandra M. Hartle , Jonathan Z. Luo, Ann N. Stepanchick, Uyenlinh L. Mirshahi, Dustin N. Hartzel, Kandamurugu Manickam, Michael F. Murray, Tooraj Mirshahi 621-Pos Board B391 MUTATIONS IN KV7.5 CHANNELS ASSOCIATED WITH INTELLECTUAL DIS- ABILITY OR EPILEPTIC ENCEPHALOPATHY. Anna Lehman, Samrat Thouta , Grazia M. S. Mancini, Marjon van Slegtenhorst, Sakkubai Naidu, Sonal Desai, Kirsty McWalter, Richard Person, Jill Mwenifumbo, Ramona Salva- rinova, Ilaria Guella, Marna B McKenzie, Matthew J. Farrer, Anita Datta, Mary B. Connolly, Michelle Demos, Somayeh Mojard Kalkhoran, Damon Poburko, Jan M. Friedman, Thomas Claydon 622-Pos Board B392 ACTIVATION OF N -METHYL- D -ASPARTATE RECEPTOR INHIBITS ENKEPHA- LINERGIC NEURONS IN THE SUPERFICIAL DORSAL HORN OF MOUSE SPINAL CORD. Eiko Kato , Yuuichi Hori 623-Pos Board B393 EXOTIC PROPERTIES OF A VOLTAGE GATED PROTON CHANNEL IN THE SNAIL HELISOMA TRIVOLVIS . Vladimir V. Cherny, Sarah Thomas, Deri Morgan, Susan ME Smith, Thomas E. DeCoursey 624-Pos Board B394 GATING CURRENTS IN HV1 PROTON CHANNELS. Victor De La Rosa, I. Scott Ramsey 625-Pos Board B395 RAPID GATING KINETICS OF A VOLTAGE GATED PROTON CHANNEL IN THE SNAIL HELISOMA TRIVOLVIS . Sarah A. Thomas, Vladimir V. Cherny, Deri Morgan, Liana Artinian, Vincent L. Rehder, Thomas E. DeCoursey, Susan M. E. Smith 626-Pos Board B396 INSIGHT INTO THE ROLE OF HV1 C-TERMINAL DOMAIN IN DIMER STABILI- ZATION. Panisak Boonamnaj, Pornthep Sompornpisut 627-Pos Board B397 ZN 2+ MODULATES HV1 PROTON CHANNEL GATING VIA CONFORMATION- AL COUPLING TO AN INTRACELLULAR COULOMBIC NETWORK.  Ashley L. Bennett , Victor De La Rosa, I. Scott Ramsey

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