Biophysical Society 62nd Annual Meeting | Program Guide

669-Pos Board B439 NONEQUILIBRIUMMOLECULAR DYNAMICS (MD) SIMULATIONS OF MULTI-ION PERMEATION IN KCSA. Robert A. Farley , Sarah Holzmann, Cameron Kopp, Yi Shi, Yibo Wang, Sergei Noskov, Van A. Ngo 670-Pos Board B440 PERMEATION OF ANTIBIOTICS ACROSS PORINS. Mathias Winterhalter , Satya Prathysha Bhamidimarri, Ishan Ghai, Jiajun Wang 671-Pos Board B441 THE RESIDUES IN THE amINO TERMINAL AND FIRST EXTRACELLULAR DOMAINS AND INTRACELLULAR MAGNESIUM INFLUENCE CX50 UNITARY GAP JUNCTION CHANNEL CONDUCTANCE. Mary Grace Tejada, Swathy Sudhakar, Hiroshi Aoyama, Donglin Bai 672-Pos Board B442 INVESTIGATION OF ANION SELECTIVITY OF CLC-K CHANNELS. Laura Lagostena, Michael Pusch, Alessandra Picollo 673-Pos Board B443 Education Travel Awardee IONIC PERMEATION AND THE NATURE OF ION SELECTIVITY IN CLAUDIN PARACELLULAR CHANNELS. Priyanka Samanta , Yitang Wang, Shadi Fu- ladi, Jinjing Zou, Le Shen, Christopher Weber, Fatemeh Khalili-Araghi 674-Pos Board B444 BACTERIAL PORINS AS ELECTROSTATIC NANOSIEVES: EXPLORING TRANS- PORT RULES OF SMALL POLAR MOLECULES. Harsha Bajaj, Silvia Acosta Gutierrez, Igor Bodrenko, Giuliano Malloci, Mariano Andrea Scorciapino, Mathias Winterhalter, Matteo Ceccarelli 675-Pos Board B445 Education Travel Awardee MECHANISM OF PH GATING IN CX26 GAP JUNCTION CHANNELS RE- VEALED BY CRYOEM, CROSSLINKING AND HDX. Maciej Jagielnicki , Ali Khan, William E. McIntire, Michael D. Purdy, Venkat Dharmarajan, Patrick R. Griffin, Mark Yeager 676-Pos Board B446 THE EFFECT OF BARREL GEOMETRY ON ION CONDUCTION THROUGH E. COLI OMPX. Curtis Balusek , Dirk Linke, James C. Gumbart 677-Pos Board B447 A NEWLY AVAILABLE TOOL FOR FUNCTIONAL ANNOTATION OF ION CHANNEL STRUCTURES BASED ON MOLECULAR DYNAMICS SIMULA- TIONS. Gianni Klesse , Shanlin Rao, Phillip J. Stansfeld, Mark S. P. Sansom, Stephen J. Tucker 678-Pos Board B448 HYDROPHOBIC GATING: EXAMINATION OF RECENT ION CHANNEL STRUC- TURES. Shanlin Rao , Gianni Klesse, Stephen J. Tucker, Mark S.P. Sansom 679-Pos Board B449 CONFORMATIONAL LANDSCAPE OF SUBSTRATE SPECIFICITY IN THE FRUCTOSE TRANSPORTER GLUT5 DETERMINED VIA MBAR MOLECULAR DYNAMICS. Trevor Gokey , Jesi Lee, Anton B. Guliaev Skeletal Muscle Mechanics, Structure, and Regulation I (Boards B450–B463) 680-Pos Board B450 EVIDENCE FOR ACTIN FILAMENT STRUCTURAL CHANGES AFTER ACTIVE SHORTENING IN SKINNED MUSCLE BUNDLES. Venus Joumaa , Ian Curtis Smith, Atsuki Fakutani, Tim Leonard, Weikang Ma, Thomas Irving, Walter Herzog 681-Pos Board B451 RESONANT REFLECTION SPECTROSCOPY AND OPTICAL INTERFEROMETRY TO MEASURE SARCOMERE STRUCTURE IN MUSCLE. Kevin W. Young, Bill P.-P. Kuo, Shawn M. O’Connor, Stojan Radic, Richard L. Lieber

682-Pos Board B452 RESIDUAL FORCE ENHANCEMENT IS ATTENUATED BY SHORTENING IN A MAGNITUDE-DEPENDENT MANNER. Atsuki Fukutani , Walter Herzog 683-Pos Board B453 THE NONLINEAR MECHANICAL PROPERTIES OF TITIN MODULATE STRI- ATED MUSCLE CONTRACTION EFFICIENCY.  Joseph D. Powers , C. David Williams, Michael Regnier, Thomas L. Daniel 684-Pos Board B454 TROPOMYOSIN TRANSLOCATION ON F-ACTIN REVEALED BY MOLECULAR DYNAMICS SIMULATIONS. Farooq A. Kiani , Michael J. Rynkiewicz, Stefan Fischer, William Lehman 685-Pos Board B455 A NOVEL FLNC FRAMESHIFT AND AN OBSCN VARIANT IN A FAMILY WITH DISTAL MUSCULAR DISTROPHY. Daniela Rossi , Johanna Palmio, Anni Evilä, Stefania Lorenzini, Galli Lucia, Virginia Barone, Tracy A. Caldwell, Rachel A. Polike, Aldkheil Esraa, Berndsen E. Christopher, Nathan T. Wright, Peter Hackmann, Bruno Eymard, Bjarne Udd, Vincenzo Sorrentino 686-Pos Board B456 IS THIN FILAMENT MOVEMENT SWITCHED ON AND OFF BY A THERMO- DYNAMIC PROCESS ALONE. Henry G. Zot , Bryant Chase, Javier E. Hasbun, Jose R. Pinto 687-Pos Board B457 MAPPING ALLOSTERIC PATHWAYS IN THE MYOSIN MOTOR DOMAIN VIA THE W-HELIX/TRANSDUCER REGION LEADING TO FORCE PRODUC- TION. Peter Franz , Wiebke Ewert, Matthias Preller, Georgios Tsiavaliaris 688-Pos Board B458 SARCOMERE BREATHING: DOES FLOWWITHIN CONTRACTING MYOFI- BRILS INFLUENCE SUBSTRATE DELIVERY?  Julie A. Cass , Anette L. Hosoi, Tom L. Daniel 689-Pos Board B459 MYBP-C PHOSPHORYLATION ACCELERATES SARCOMERE SHORTENING AS THIN FILAMENTS SLIDE THROUGH THE C-ZONE.  Joel C. Robinett , Laurin M. Hanft, Kerry S. McDonald 690-Pos Board B460 THE SKELETAL MUSCLE MOLECULAR CLOCK REGULATES TITIN SPLICING AND PROTEIN EXPRESSION. Lance A. Riley , Joseph R. Mijares, Xiping Zhang, Karyn A. Esser 691-Pos Board B461 3-D STRUCTURE OF Z-DISKS ISOLATED FROM THE FLIGHT MUSCLE OF LETHOCERUS INDICUS. Fatemeh A. Yeganeh , Corrine Summerill, Zhongjun Hu, Hamidreza Rahmani, Dianne W. Taylor, Kenneth A. Taylor 692-Pos Board B462 ROLE OF THICK FILAMENT INACTIVATION DURING ISOTONIC SHORTEN- ING IN STRIATED MUSCLE. Kerry S. McDonald , Kenneth S. Campbell 693-Pos Board B463 SEX-RELATED DIFFERENCES IN SARCOMERIC PROTEIN EXPRESSION IN GUINEA PIG MASTICATORY MUSCLES. Peter J. Reiser , Natalya Belevych, Kelly Doan, Jarid R. Jones, Suarav Kadatane Cardiac Muscle Regulation I (Boards B464–B478) 694-Pos Board B464 CA 2+ -INDUCED MOVEMENT OF TROPOMYOSIN ON NATIVE CARDIAC THIN FILAMENTS REVEALED BY CRYOELECTRON MICROSCOPY. Cristina Risi, Betty Belknap, David H. Heeley, Howard D. White, Gunnar Schröder, Vitold E. Galkin

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