Biophysical Society 62nd Annual Meeting | Program Guide

708-Pos Board B478 A MOLECULAR APPROACH TO UNDERSTAND THE SUPER-RELAXED STATE OF MYOSIN OBSERVED IN CARDIAC MUSCLE. Saswata S. Sarkar , Darshan V. Trivedi, Makenna M. Morck, Arjun S. Adhikari, Kathleen M. Ruppel, James A. Spudich Actin Structure, Dynamics, and Associated Proteins (Boards B479–B501) 709-Pos Board B479 INSIGHTS INTO THE COOPERATIVE NATURE OF ATP HYDROLYSIS IN ACTIN FILAMENTS. Harshwardhan H. Katkar , Aram Davtyan, Aleksander E. P. Durumeric, Glen M. Hocky, Anthony Schramm, Enrique M. De La Cruz, Gregory A. Voth 711-Pos Board B481 FUNCTIONS AND DYNAMICS OF ACTIN WAVES. Simone Mortal , Federico Iseppon, Andrea Perissinotto, Elisa D’Este, Dan Cojoc, Luisa M. R. Napoli- tano, Vincent Torre 710-Pos Board B480 NUCLEOTIDE AND POLYMERIZATION EFFECTS ON THE STRUCTURE AND DYNAMICS OF ACTIN. Lauren Jepsen , David Sept 712-Pos Board B482 THE MECHANOSENSITIVITY OF ACTIN BUNDLES. Emiko Suzuki , Antoine Jégou, Guillaume Romet-Lemonne 713-Pos Board B483 ELECTROPHORETIC CYTOMETRY ELUCIDATES STRESS-INDUCED ACTIN CYTOSKELETAL REORGANIZATION.  Julea Vlassakis , Ryo Higuchi-Sanabria, Andrew Dillin, amy E. Herr 714-Pos Board B484 CYTOSKELETAL REMODELING DURING OXIDATIVE AND THERMAL STRESS. Federico Sesti , Rahul Patel 715-Pos Board B485 EFFECTS OF MECHANICAL STRESS ON PERIODONTAL LIGAMENT.  Ayano Fujita , Masatoshi Morimatsu, Masayoshi Nishiyama, Shogo Ta- kashiba, Keiji Naruse 716-Pos Board B486 MODELING OF ACTOMYOSIN NETWORKS WITH A MOLECULAR UNDER- PINNING OF CROSS-LINKER PROTEINS.  James Liman , Yossi Eliaz, Herbert Levine, Margaret S. Cheung 717-Pos Board B487 VISUALIZING DIRECT INTERACTIONS IN THE MECHANOBIOME.  Priyanka Kothari , Vasudha Srivastava, Vasudha Aggarwal, Irina Tcher- nyshyov, Jennifer Van Eyk, Taekjip Ha, Douglas N. Robinson 718-Pos Board B488 PKC PHOSPHORYLATION AND MU-CALPAIN TRUNCATION OF THE C-TER- MINAL END SEGMENT OF SM22ALPHA REGULATES ITS F-ACTIN BINDING AND MECHANICAL TENSION MODULATED DEGRADATION. Hui Wang , M. Moazzem Hossain, Jian-Ping Jin 719-Pos Board B489 MODELING PULLING FORCE GENERATION BY ENSEMBLES OF POLYMER- IZING ACTIN FILAMENTS. Fowad Motahari , A. E. Carlsson 720-Pos Board B490 FORMIN’S PROCESSIVITY UNDER APPLIED FORCE. LuYan Cao , Mikaël Kerleau, Antoine Jégou, Guillaume Romet-Lemonne 721-Pos Board B491 MDIA1 SENSES BOTH FORCE AND TORQUE DURING F-ACTIN FILAMENT POLYMERISATION. Miao Yu , Xin Yuan, Michael Sheetz, Alexander Ber- shadsky, Jie Yan

695-Pos Board B465 SUPER-STABLE PHOSPHORYLATION DEPENDENT INTRAMOLECULAR INTERACTIONS REGULATE THE STRUCTURE AND FUNCTION OF MYBP- C. Sheema Rahmanseresht, Arthur J. Michalek, James Gulick, Jeffrey Robbins, David M. Warshaw, Michael J. Previs 696-Pos Board B466 EFFECT OF A UNIQUE POLYMOPHISM IN TROPOMYOSIN-BINDING SITE 1 OF TOAD SLOW SKELETAL MUSCLE TROPONIN T ON CARDIAC FUNC- TION. Hanzhong Feng , Shirin Akhter, Hui Wang, Jian-Ping Jin 697-Pos Board B467 HYPERTROPHIC CARDIOMYOPATHY MUTATIONS DISRUPT HUMAN BETA CARDIAC MYOSIN INTRAMOLECULAR INTERACTIONS LEADING TO INCREASED MYOSIN ACTIVITY. Arjun S. Adhikari , Darshan V. Trivedi, Saswata S. Sarkar, Kathleen M. Ruppel, Spudich A. James 698-Pos Board B468 DETECTION OF THE SUPER-RELAXED STATE IN CARDIAC HEAVY MEROMY- OSIN.  John A. Rohde , Lien Phung, David D. Thomas, Joseph M. Muretta 699-Pos Board B469 SIGNALING PATHWAYS AFFECTED IN CARDIAC CELLS BY IBUPRO- FEN. Shuchita Tiwari , Aldrin Gomes 700-Pos Board B470 SUPPRESSING DETYROSINATED MICROTUBULES IMPROVES MY-CUTE FUNCTION IN HUMAN HEART FAILURE. Christina Yingxian Chen , Mat- thew A. Caporizzo, Kenneth Bedi, Michael P. Morley, Kenneth B. Margu- lies, Benjamin L. Prosser 701-Pos Board B471 DISSECTING THE MOLECULAR MECHANISM FOR FAMILIAL CARDIOMY- OPATHIES. Sarah R. Clippinger , Lina Greenberg, Michael J. Greenberg 702-Pos Board B472 THE EPAC2 INHIBITOR ESI-05 PROLONGS THE ACTION POTENTIAL AND INCREASES SUSCEPTIBILITY TO EAD ARRHYTHMIAS. Hannah M. Kirton , Moza Al-Owais, Chris Peers, Derek S. Steele 703-Pos Board B473 RELATION BETWEEN VOLUNTARY EXERCISE FREQUENCY AND CARDIAC FUNCTION IN DILATED CARDIOMYOPATHY MODEL MICE.  Masami Sugihara , Ryo Kakigi, Takashi Murayama, Takashi Miida, Takashi Sakurai, Sachio Morimoto, Nagomi Kurebayashi 704-Pos Board B474 THERAPEUTIC EFFECTS OF GHRELIN AND DES-ACYL GHRELIN ON DOXO- RUBICIN-INDUCED CARDIOTOXICITY. Miki Nonaka , Nagomi Kurebayashi, Takashi Murayama, Masami Sugihara, Hiroshi Hosoda, Shosei Kishida, Kenji Kangawa, Takashi Sakurai, Yasuhito Uezono 705-Pos Board B475 ROLE OF ELECTROSTATIC INTERACTIONS IN THE ISOFORM-SPECIFIC RATE OF ADP RELEASE FROM HUMAN CARDIAC MYOSIN. Akhil Gargey , Jinghua Ge, Yaroslav Tkachev, Yuri Nesmelov 706-Pos Board B476 Education Travel Awardee CARDIOMYOPATHY-LINKED MUTATION K15N IN TROPOMYOSIN ALTERS CALCIUM-DEPENDENT REGULATION OF RECONSTITUTED CARDIAC THIN FILAMENTS. Thu N. Ly , William Schlecht, Mert Colpan, Wen-Ji Dong, Alla S. Kostyukova 707-Pos Board B477 VERY-LOW-DENSITY LIPOPROTEIN OF METABOLIC SYNDROME SUP- PRESSES STORE-OPERATED CALCIUM ENTRY THROUGH MODULATIONS OF STIM1 IN HL-1 ATRIAL MYOCYTES. Hsiang-Chun Lee , Yi-Lin Shiou, I-Chieh Huang

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