Biophysical Society 62nd Annual Meeting | Program Guide

734-Pos Board B504 THE ELUSIVE PROTON IN THE GASTRIC PROTON POTASSIUM ATPASE. Vi- kas Dubey, Kazuhiro Abe, Ilia Solov’yov, Himanshu Khandelia 735-Pos Board B505 PROPERTIES OF OSCILLATING ELECTRICAL PULSE INDUCED NA/K PUMP CURRENT ON SINGLE FROG SKELETAL MUSCLE. Pengfei Liang , Wei Chen 736-Pos Board B506 CONTRIBUTION OF THE HYDROXYL GROUP AND PHENOL RING OF TYROSINE 780 OF THE ALPHA-SUBUNIT TO NA + BINDING BY THE NA/K PUMP. Kerri Spontarelli , Daniel Infield, Chris A. Ahern, Pablo Artigas 737-Pos Board B507 BETA-DEPENDENT MODULATION OF NA + BINDING AND RELEASE OF THE ALPHA-3 NA + K + PUMP. Cristina Moreno Vadillo , Miguel Holmgren 738-Pos Board B508 CRYSTAL STRUCTURES OF SERCA2A AND SERCA2B. Haruo Ogawa , Yoshiki Kabashima, Rie Nakajima, Chikashi Toyoshima 739-Pos Board B509 DISCOVERY OF SERCA2A/PLB ACTIVATORS AND INHIBITORS BY STRUC- TURE-BASED HIGH-THROUGHPUT SCREENING USING LIVE CELL FRET BIOSENSORS. Daniel R. Stroik , Samantha L. Yuen, Kevyn A. Janicek, Tory M. Schaaf, Razvan L. Cornea, David D. Thomas 740-Pos Board B510 BINDING AFFINITY OF SERCA REGULATORY COMPLEXES QUANTIFIED BY STEERED MOLECULAR DYNAMICS SIMULATIONS. Nikolai Smolin , Seth L. Robia 741-Pos Board B511 THE ALLOSTERIC COUPLING OF THE CYTOPLASMIC PHOSPHORYLATION AND TRANSMEMBRANE DOMAIN DEOCCLUSION IN THE CA 2+ SERCA PUMP ELUCIDATED BY FREE ENERGY SIMULATIONS. Huan Rui , Avisek Das, Benoit Roux 742-Pos Board B512 IS ATP HYDROLYSIS THE POWER STROKE IN ABC TRANSPORTERS?  Hendrik Göddeke , Marten Prieß, Gerrit Groenhof, Lars Schäfer 743-Pos Board B513 MECHANISM OF LARGE-SCALE ALTERNATING ACCESS CONFORMATIONAL TRANSITION IN THE ABC EXPORTER TM287/288. Hendrik Göddeke, Mikko Karttunen, Lars V. Schäfer 744-Pos Board B514 LIPID-DEPENDENT ALTERNATING ACCESS MECHANISM IN ABC EXPORT- ERS REVEALED USING MICROSECOND-LEVEL MOLECULAR DYNAMICS SIMULATIONS. Mahmoud Moradi , Jeevapani Hettige 745-Pos Board B515 STUDY OF CONFORMATIONAL TRANSITION OF A PROTEIN SECRETION ABC TRANSPORTER USING MOLECULAR DYNAMIC . Ahmad Raeisi Najafi , Reza Dastvan, Hassane S. Mchaourab, Emad Tajkhorshid 746-Pos Board B516 LIPID BINDING AND LIPID-UPTAKE IN P-GLYCOPROTEIN: COMPARISON OF THE INWARD- AND OUTWARD-FACING CONFORMATION. Estefania Barreto-Ojeda , Abigael Gritter, Valentina Corradi, Peter Tieleman 747-Pos Board B517 LIPIDS AND IONS TRAVERSE THE MEMBRANE BY THE SAME PHYSICAL PATHWAY IN THE NHTMEM16 SCRAMBLASE. Tao Jiang , Kuai Yu, H Criss Hartzell, Emad Tajkhorshid

722-Pos Board B492 COMPETITION amONG MULTIPLE PATHWAYS FOR SUBUNIT ADDITION IN FORMIN-MEDIATED ACTIN FILAMENT ELONGATION. Mark E. Zweifel, Naomi Courtemanche 723-Pos Board B493 MULTISCALE MODEL OF THE FORMIN HOMOLOGY 1 DOMAIN ILLUS- TRATES ITS ROLE IN REGULATION OF ACTIN POLYMERIZATION.  Brandon G. Horan , Gül Zerze, Gregory L. Dignon, Young C. Kim, Dimitrios Vavylonis, Jeetain Mittal 724-Pos Board B494 THE DROSOPHILA FORMIN FHOD NUCLEATES ACTIN FILAMENTS.  Aanand A. Patel , Zeynep A. Oztug Durer, Aaron P. van Loon, Kathryn V. Bremer, Margot E. Quinlan 725-Pos Board B495 COFILIN INDUCES A LOCAL CHANGE IN THE TWIST OF ACTIN FILA- MENTS. Andrew R. Huehn , Wenxiang Cao, W. Austin Elam, Enrique De La Cruz, Charles V. Sindelar 726-Pos Board B496 MECHANOTRANSMISSION AND MECHANOSENSING OF HUMAN ALPHA- ACTININ 1. Shimin Le , Xian Hu, Mingxi Yao, Hu Chen, Michael P. Sheetz, Jie Yan 727-Pos Board B497 Education Travel Awardee COMPUTATIONAL MODELING OF ENA/VASP INTERACTING WITH ACTIN FILAMENT TO UNDERSTAND ITS PROCESSIVITY. Fikret Aydin , Aleksander Durumeric, Harshwardhan Katkar, Gregory A. Voth 728-Pos Board B498 Education Travel Awardee BINDING OF THE N2A REGION OF TITIN TO ACTIN FILAMENTS.  Christopher M. Tsiros , Humra Athar, Matthew Gage 729-Pos Board B499 STOCHASTIC SIMULATIONS OF TROPOMYOSIN BINDING AND DIFFUSION ON FILAMENTOUS ACTIN. Mikkel H. Jensen , Ashley Luiz, Hai Tran 730-Pos Board B500 C1 IG-DOMAIN OF MYOSIN BINDING PROTEIN-C ACTIVATES CARDIAC THIN FILAMENT BY MEANS OF THETHERING TROPOMYOSIN TO THE SUBDOMAIN-1 OF ACTIN. Cristina Risi , Betty Belknap, Tyler Glendrange, Samantha Harris, Howard D. White, Gunnar Schröder, Vitold E. Galkin 731-Pos Board B501 STRUCTURAL BASIS FOR HIGH-AFFINITY ACTIN BINDING REVEALED BY A B-III-SPECTRIN SCA5 MISSENSE MUTATION. Michael E. Fealey , AdamW. Avery, Fengbin Wang, Albina Orlova, Andrew R. Thompson, Edward H. Egelman, Thomas S. Hays, David D. Thomas Membrane Pumps, Transporters, and Exchangers I (Boards B502–B525) 732-Pos Board B502 THERMAL EQUILIBRIUM AND ENERGY CONVERSION OF A NEW PHOTO- RECEPTOR WITH TWO CHROMOPHORES AS STUDIED BY IN SITU SPEC- TROSCOPY. Xiaoyan Ding, Chao Sun, Haolin Cui, Yujiao Gao, Juan Wang, Yanan Yang, Xin Zhao 733-Pos Board B503 MEASURING TRANSPORT KINETICS OF LIGHT DRIVEN MEMBRANE PRO- TEIN, HALORHODOPSIN. Hasin M. Feroz, Bryan Ferlez, Cecile Lefoulon, Hossein Mohammadiarani, Tingwei Rei, Carol S. Baker, Peter J. Butler, Jo- nas Hühn, Cheryl A. Kerfeld, Nigel J. Burroughs, Harish Vashisth, Wolfgang Parak, Mike Blatt, John Golbeck, Manish Kumar

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