Biophysical Society 62nd Annual Meeting | Program Guide

Platform Ion Channels, Pharmacology, and Disease 10:45 am–12:45 pm, Esplanade, Room 155 Co-Chairs Rebecca Howard, Stockholm University, Sweden Heike Wulff, University of California, Davis 1020-Plat 10:45 am CPOW Travel Awardee DISSECTING FUNCTION AND DISTRIBUTION OF SODIUM CHANNELS AND GAP JUNCTIONAL PROTEINS USING SUPERRESOLUTION PATCH-CLAMP.  Anita Alvarez-Laviada , Rengasayee Veeraraghavan, Vania Braga, Robert Gourdie, Julia Gorelik 1021-Plat 11:00 am INHIBITION OF THE POTASSIUM CHANNEL KV1.3 REDUCES INFARCTION AND INFLAMMATION IN ISCHEMIC STROKE.  Heike Wulff , Yi-Je Chen, Hai M. Nguyen, Izumi Maezawa, Lee-Way Jin 1022-Plat 11:15 am A MINIMAL PROTEIN REGION REQUIRED FOR THE CHEMICAL ACTIVATION OF THE MECHANOSENSITIVE CHANNEL PIEZO1.  Jerome J. Lacroix 1023-Plat 11:30 am KNOTBODIES: A NEW GENERATION OF ION CHANNEL THERAPEUTIC BIO- LOGICS CREATED BY FUSING KNOTTIN TOXINS INTO ANTIBODIES.  Damian C. Bell , Aneesh Karratt-Vellatt, Sachin Surade, Tim Luetkens, Edward W. Masters, Naja M. Sørensen, Neil Butt, John McCafferty 1024-Plat 11:45 am DIFFERENTIAL METABOLIC AND NUCLEOTIDE SENSITIVITY OF BETA-CELL AND CARDIAC K ATP CHANNELS.  Natascia Vedovato , Peter Proks, Olof H. Rorsman, Kostantin Hennis, Frances M. Ashcroft 1025-Plat 12:00 pm STRUCTURAL DETAILS OF AN ALLOSTERIC MECHANISM FOR BIMODAL ANESTHETIC MODULATION OF PENTAMERIC LIGAND-GATED ION CHAN- NELS.  Rebecca J. Howard , Zaineb Fourati, Stephanie A. Heusser, Haidai Hu, Reinis R. Ruza, Ludovic Sauguet, Erik Lindahl, Marc Delarue 1026-Plat 12:15 pm X-RAY CRYSTAL STRUCTURES OF THE INFLUENZA A M2 PROTON CHANNEL BOUND TO amANTADINE, RIMANTADINE, AND INHIBITING COMPOUNDS. Jessica L. Thomaston , William F. DeGrado 1027-Plat 12:30 pm AZOBENZENE-BASED PHOTOSWITCHES FOR THE CONTROL OF THE VOLT- AGE-GATED PROTON CHANNEL HV1.  Andreas Rennhack, Elena Grahn , U. Benjamin Kaupp, Thomas K. Berger Platform Systems Biophysics 10:45 am–12:45 pm, Esplanade, Room 156 Co-Chairs Jochen Guck, Technische Universität Dresden, Germany Jennifer Chen, Drexel University 1028-Plat 10:45 am BIOPHYSICAL TECHNIQUES FOR THE STUDY OF PHASE TRANSITIONS IN PROTEIN DROPLETS AND CELLS.  Raimund Schlüssler, Shada Abuhattum, Gheorghe Cojoc, Timon Beck, Felix Reichel, Kyoohyun Kim, Mirjam Schür- mann, Paul Müller, Jürgen Czarske, Vasily Zaburdaev, Titus Franzmann, Simon Alberti, Jochen Guck 1029-Plat 11:00 am ANALYSIS OF APOPTOTIC EVENT TIME CORRELATIONS IN SINGLE CELLS.  Alexandra Murschhauser , Peter Röttgermann, Daniel Woschee, David Garry, Martina Ober, Kenneth Dawson, Joachim O. Rädler

1008-Plat 11:45 am FUNNEL GAS MODEL FOR PROTEIN MANY-BODY SYSTEMS UNDER THE CROWDED ENVIRONMENT. Macoto Kikuchi , Yoshikatsu Tada, Nobu C. Shirai 1009-Plat 12:00 pm LIGHTING UP PROTEIN MISFOLDING AND AGGREGATES BY CHEMICAL PROBES.  Yuning Hong 1010-Plat 12:15 pm FOLDING PROTEINS FROM ONE END TO THE OTHER.  Micayla A. Bowman , Patricia L. Clark 1011-Plat 12:30 pm THE EFFECT OF THE RIBOSOME ON NASCENT CHAIN DYNAMICS.  Madeleine K. Jensen , Samuel Itskanov, Avi J. Samelson, Susan Marqusee Platform Membrane Receptors and Signal Transduction 10:45 am–12:45 pm, Esplanade, Room 154 Co-Chairs David Clarke, STFC Central Laser Facility, United Kingdom Eva Sevcsik, Technische Universität Wien, Germany 1012-Plat 10:45 am DIFFERENTIAL LAT MICROCLUSTER COMPOSITION AND ACTIN-DEPEN- DENT MOVEMENT AT THE IMMUNOLOGICAL SYNAPSE CENTER.  Anthony Vega , Jonathon Ditlev, Darius Koster, Xiaolei Su, Ron Vale, Satyajit Mayor, Michael K. Rosen, Khuloud Jaqaman 1013-Plat 11:00 am DNA ORIGAMI AS A NANOSCALE PLATFORM FOR T-CELL ACTIVATION.  Viktoria Motsch, Joschka Hellmeier, Gerhard J. Schütz, Eva Sevcsik 1014-Plat 11:15 am Education Travel Awardee BIOPHYSICAL FEATURES OF THE ΑΒTCR MECHANOME THAT DRIVE HIGH AVIDITY T-CELL RECOGNITION.  Yinnian Feng , Kristine N. Brazin, Eiji Kobayashi, Robert J. Mallis, Ellis L. Reinherz, Matthew J. Lang 1015-Plat 11:30 am FLUORESCENCE LOCALISATION IMAGING WITH PHOTOBLEACHING AT 5 NM RESOLUTION REVEALS THE ARCHITECTURE OF BASAL EGFR COMPLEXES AND MECHANISMS OF AUTOINHIBITION AND ACTIVATION.  Marisa L. Martin-Fernandez , Laura C. Zanetti-Domingues, Dimitrios Korovesis, Sarah R. Needham, Christopher J. Tynan, Selene K. Roberts, David T. Clarke, Daniel J. Rolfe, Peter J. Parker 1016-Plat 11:45 am GLYCOPROTEIN CROWDING AFFECTS CELL MEMBRANE SIGNALLING.  Hao Pan , Matthew Paszek 1017-Plat 12:00 pm TRANSIENT HETERO-DIMERIZATION OF OPIOID RECEPTORS (GPCRS) REVEALED BY SINGLE-MOLECULE TRACKING.  Peng Zhou , Rinshi S. Kasai, Koichiro M. Hirosawa, Alexey Yudin, Yuki M. Shirai, Takahiro K. Fujiwara, Akihiro Kusumi 1018-Plat 12:15 pm AN EFFICIENT MOLECULAR DYNAMICS SIMULATION STRATEGY TO INVES- TIGATE THE MECHANISTIC BASIS FOR BIASED AGONISM AT G PROTEIN- COUPLED RECEPTORS.  Derya Meral , Davide Provasi, Marta Filizola 1019-Plat 12:30 pm MOLECULAR TIMING OF MEMBRANE SIGNALING REACTIONS.  William Y. C. Huang , Steven Alvarez, Young Kwang Lee, Yasushi Kondo, Jean K. Chung, Hiu Yue Monatrice Lam, John Kuriyan, Jay T. Groves

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