Biophysical Society 62nd Annual Meeting | Program Guide

1132-Pos Board B41 DISCERNING MERCURY METHYLATION: INTERDISCIPLINARY APPROACHES TO SOLVE A COMPLEX PUZZLE. Swapneeta Date , Katherine Rush, Xiang- ping Yin, Judy Wall, Stephen Ragsdale, Jerry Parks, Dwayne Elias, Baohua Gu, Alexander Johs 1133-Pos Board B42 UNDERSTANDING THE TOXICITY AND REPURPOSING POTENTIAL OF KINASE INHIBITORS. Hammad Naveed 1134-Pos Board B43 BINDING PATHWAYS OF PHENYLALANINE TO THE DIMERIC REGULATORY DOMAIN OF HUMAN PAH REVEAL A LID GATING MECHANISM.  Yunhui Ge , Eileen K. Jaffe, Vincent A. Voelz 1135-Pos Board B44 ANTIBIOTIC PERMEATION ACROSS THE BACTERIAL OUTER MEMBRANE PORIN. Nandan Haloi , Mrinal Shekhar, Bryon S. Drown, Paul J. Hergen- rother, Emad Tajkhorshid 1136-Pos Board B45 MEASUREMENTS OF ENZYME ACTIVITY WITH FIELD-EFFECT TRANSIS- TORS. Nicholas Guros, Son T. Le, Antonio Cardone, Brent Sperling, Curt Richter, Jeffery Klauda, Harish Pant, Arvind Balijepalli 1137-Pos Board B46 THE PH DEPENDENCE OF KETAMINE BINDING TO G-PROTEIN COUPLED RECEPTORS. Thomas T. Joseph , Roderic G. Eckenhoff, Grace Brannigan 1138-Pos Board B47 AMYLOID AGGREGATION OF HIAPP, AΒ, AND CALCITONIN ALTERED BY A CURCUMIN DERIVATIVE. Sarah J. Cox , Diana C. Rodriguez Camargo, Young-Ho Lee, Bernd Reif, Magdalena Ivanova, Ayyalusamy Ramamoor- thy 1139-Pos Board B48 BINDING BEHAVIOR AND ENERGETICS BETWEEN CURCUMIN AND amYLOID-Β AGGREGATES AT THE MOLECULAR SCALE. Tye D. Martin , Angelina J. Malagodi, Eva Y. Chi, Deborah G. Evans 1140-Pos Board B49 NDGA INHIBITS FUNCTIONAL amYLOID BIOSYNTHESIS AND BIOFILM FOR- MATION BY UROPATHOGENIC E. COLI.  Joshua A. Visser , Lynette Cegelski 1141-Pos Board B50 INTERROGATING FUNCTIONAL amYLOID FORMATION USING SMALL MOLECULES. Elizabeth Gichana Protein Assemblies II (Boards B51–B68) 1142-Pos Board B51 International Travel Awardee EFFECT OF HYPERGLYCEMIC CONDITIONS ON THE EARLY SELF-ASSEMBLY OF THE ALZHEIMER’S amYLOID BETA PEPTIDE: IMPLICATIONS FOR NEU- ROTOXICITY. Sneha Menon, Neelanjana Sengupta 1143-Pos Board B52 OLIGOMERIZATION AND FIBRILLIZATION DYNAMICS OF amYLOID PEP- TIDES AND BETA-BARREL OLIGOMER INTERMEDIATES. Yunxiang Sun , Xinwei Ge, Feng Ding 1144-Pos Board B53 THE GLYCOLYTIC ENZYME PHOSPHOFRUCTOKINASE-1 ASSEMBLES INTO FILAMENTS. Bradley Webb , Annie Dosey, Torsten Wittmann, Justin Koll- man, Diane Barber 1145-Pos Board B54 THE STRUCTURE OF THE INFECTIOUS PRION PROTEIN CONSTRAINS POTENTIAL PRION REPLICATION MECHANISMS. Holger Wille , Jesús R. Requena

1119-Pos Board B28 LOOP SUBSTITUTION WITH BETA TURNS DISRUPTS FIBRIL FORMATION IN amYLOID MODEL SEQUENCES. Heng Chi 1120-Pos Board B29 TOPOLOGY OF PLASMIN-DRIVEN FIBRINOLYSIS IN A NANOSCALE FIBRIN MATRIX. Tímea Feller , Jolán Hársfalvi, Csilla Csányi, Balazs Kiss, Miklós Kellermayer 1121-Pos Board B30 Education Travel Awardee CHARACTERIZATION OF THE MOLECULAR MECHANISM FOR MATURA- TION INHIBITORS AGAINST THE HIV-1 CAPSID-SP1 DOMAIN.  Carly A. Sciandra , Pengfei Ding, Eric O. Freed, Michael F. Summers Protein-Small Molecule Interactions II (Boards B31–B50) 1122-Pos Board B31 ENGINEERING TARGETED LECTINS BY COMPUTER-GUIDED DIRECTED EVOLUTION.  Ismail C. Kazan , Prerna Sharma 1123-Pos Board B32 PROBING THE INTERACTION OF ABETA42 amYLOID SPECIES WITH AN AGGREGATION SUPPRESSOR MOLECULE BY INFRARED NANOSPECTROS- COPY. Francesco Simone Ruggeri , Johnny Habchi, Sean Chia, Michele Vendruscolo, Tuomas P. J. Knowles 1124-Pos Board B33 INTERACTIONS OF QUINAZOLINE DERIVATIVES WITH BETA-AMY- LOID. Praveen Nekkar Rao , Tarek Mohamed, Arash Shakeri 1125-Pos Board B34 LIGAND BINDING STUDIES OF A PLASMID ENCODED DIHYDROFOLATE REDUCTASE BY 19 F NMR. Gabriel J. Fuente Gomez 1126-Pos Board B35 THE REGULATION OF SURFACE CHARGE BY BIOLOGICAL OSMOLYTES.  Roy Govrin 1127-Pos Board B36 MECHANISM OF ALLOSTERIC MODULATOR BINDING TO THE ADENOSINE A 1 RECEPTOR. Yinglong Miao 1128-Pos Board B37 EFFECTS OF TRIMETHYLAMINE-N-OXIDE ON THE CONFORMATION OF PEPTIDES AND PROTEINS. Zhaoqian Su , Farbod Mahmoudinobar, Cris- Board B39 SYSTEMATIC DEVELOPMENT OF SMALL MOLECULES TO INHIBIT SPECIFIC MICROSCOPIC STEPS OF amYLOID-BETA42 AGGREGATION IN ALZHEIM- ER’S DISEASE. Sean Chia , Johnny Habchi, Ryan Limbocker, Benedetta Mannini, Minkoo Ahn, Michele Perni, Oskar Hansson, Paolo Arosio, Janet R. Kumita, Pavan Kumar Challa, Samuel I.A. Cohen, Sara Linse, Christo- pher M. Dobson, Tuomas P.J. Knowles, Michele Vendruscolo 1131-Pos Board B40 ARRHYTHMOGENIC CARDIOMYOPATHY RELATED DSG2 MUTATIONS AF- FECT DESOMOSMAL BINDING KINETICS. Mareike Dieding, Jana D. Debus, Raimund Kerkhoff, Anna Gaertner-Rommel, Volker Walhorn , Hendrik Milting, Dario Anselmetti tiano Dias 1129-Pos Board B38 INDUCIBLE GENE EXPRESSION AND PROTEIN LOCALIZATION USING CRISPR/DCAS9 AND ANTIVIRAL PROTEASE INHIBITORS. Elliot P. Tague , John Ngo 1130-Pos

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