Biophysical Society 62nd Annual Meeting | Program Guide

1175-Pos Board B84 PROTEIN DIFFUSION IN A DENSE SOLUTION STUDIED BY ALL-ATOMMO- LECULAR DYNAMICS SIMULATIONS. Grzegorz Nawrocki , Po-hung Wang, Isseki Yu, Yuji Sugita, Michael Feig 1176-Pos Board B85 HIDDEN NATIVE STATE ENSEMBLES OF NFΚB DIMERS PROVIDE INSIGHTS INTO THEIR DIFFERENT DNA-BINDING AFFINITIES. Wei Chen , Dominic Narang, Clarisse G. Ricci, Elizabeth A. Komives 1177-Pos Board B86 CORRELATED MOTIONS IN SEVERAL VARIANTS OF THE DHFR-NADPH COMPLEX. Annika Hirmke , Malvika Dua, Craig J. Early, Paul F. Maxson, Muhammad Mujtaba, Moataz Noureddine, Arish Mudra Rakshasa, Heather A. Carlson, Michael G. Lerner 1178-Pos Board B87 DISSECTING THE STRUCTURAL MECHANISM OF A NATURALLY OCCURING VARIANT OF THE PRION PROTEIN IN PREVENTING PRION DISEASE. Yiming Tang, Guanghong Wei 1179-Pos Board B88 DRIVERS OF CONFORMATIONAL VARIABILITY IN TRANSTHYRETIN MONO- MERS UNDER amYLOIDOGENIC CONDITIONS. Matthew C. Childers , Valerie Daggett 1180-Pos Board B89 QUANTIFYING PEPTIDE BINDING AFFINITIES FROM NON-EQUILIBRIUM WORK. Onur Serçinoğlu, Pemra Ozbek Sarica Membrane Protein Structures I (Boards B90–B110) 1181-Pos Board B90 DISSOCIATION OF THE HETEROTRIMERIC G PROTEIN COMPLEX BY NANOBODIES: POTENTIAL USES IN THE MODULATION OF DIVERSE GPCR SIGNALING. Krzysztof Palczewski 1182-Pos Board B91 STRUCTURE AND DYNAMICS OF THE RECEPTOR-BOUND GHRELIN LIPOPEPTIDE. Guillaume Ferré , Marjorie Damian, Céline M’Kadmi, Olivier Saurel, Georges Czaplicki, Pascal Demange, Jacky Marie, Nicolas Floquet, Jean-Alain Fehrentz, Alain Milon, Jean-Louis Banères 1183-Pos Board B92 HOT-SPOT RESIDUES TO BE MUTATED COMMON IN G PROTEIN-COUPLED RECEPTORS OF CLASS A: IDENTIFICATION OF THERMOSTABILIZING MUTATIONS FOLLOWED BY DETERMINATION OF THREE-DIMENSIONAL STRUCTURES FOR TWO EXAMPLE RECEPTORS. Satoshi Yasuda , Yuta Kajiwara, Yosuke Toyoda, Kazushi Morimoto, Ryoji Suno, So Iwata, Takuya Kobayashi, Takeshi Murata, Masahiro Kinoshita 1184-Pos Board B93 CHARACTERIZING A NEWMECHANISM IN GPCR SIGNALING AND ENERGY BALANCE. Valerie Chen , Ashley Tess Wong 1185-Pos Board B94 INTRACELLULAR EFFECT OF Β3-ADRENOCEPTOR AGONIST CARAZOLOL ON SKELETAL MUSCLE, A DIRECT INTERACTION WITH SERCA.  Ibrahim A. Ramirez , Eduardo Rodriquez, Rocío Alvarez, Eugenio Quiroz, Alicia Ortega 1186-Pos Board B95 SPATIALLY CONSTRAINED WATER MOLECULES ARE CONSERVED IN GPCR ACTIVATION. AJ Venkatakrishnan , Ron Dror 1187-Pos Board B96 Education Travel Awardee STRUCTURE OF A PHOSPHATIDYLINOSITOL-PHOSPHATE SYNTHASE FROM MYCOBACTERIA. Meagan L. Belcher Dufrisne , Carla D. Jorge, Oliver B. Clarke, Wayne A. Hendrickson, Helena Santos, Filippo Mancia

1188-Pos Board B97 BICELLE RECONSTITUTION OF ION CHANNEL DOMAINS FOR NMR STRUC- TURAL STUDIES. Jing Zhu, Mangmang Zhu, Sebastien F. Poget 1189-Pos Board B98 TOWARDS TRULY STEALTH NANODISCS. Cheol Jeong , Ryan Franklin, Karen Edler, Joseph E. Curtis 1190-Pos Board B99 QUATERNARY STRUCTURE OF SMALL amINO ACIDS TRANSPORTER OPRG OF PSEUDOMONAS AERUGINOSA . Raghavendar Reddy Sanganna Gari , Patrick Seelheim, Brendan Marsh, Volker Kiessling, Carl Creutz, Lukas Tamm 1191-Pos Board B100 NMR STRUCTURAL STUDIES OF THE YERSINIA PESTIS OUTER MEMBRANE PROTEIN AIL IN LIPID BILAYERS. Yong Yao , Lynn Fujimoto, Samit Dutta, Francesca Marassi 1192-Pos Board B101 MEMBRANE INTERACTIONS OF THE PROTEASE MT1-MMP.  Tara C. Marcink , Bo An, Barbara Brodsky, Tommi White, Steven R. Van Doren 1193-Pos Board B102 STRUCTURES, DYNAMICS, AND FUNCTIONS OF VIRAL MEMBRANE PRO- TEINS BY NMR. Luis G. Basso , Sang H. Park, Antonio J. Costa-Filho, Stanley J. Opella 1194-Pos Board B103 SITE-DIRECTED SPIN-LABEL EPR SPECTROSCOPY OF INFLUENZA A M2 PROTEIN. Aaron Holmes , Kathleen Howard 1195-Pos Board B104 A STRUCTURAL AND COMPUTATIONAL STUDY OF BARIUM BLOCKADE IN THE KCSA CHANNEL. Ahmed Rohaim , LiDong Gong, Jing Li, Huan Rui, Benoit Roux 1196-Pos Board B105 STRUCTURAL AND FUNCTIONAL STUDIES UNCOVER TWO NETWORKS STABILIZING THE ACTIVE FORM OF GLIC, A BACTERIAL PROTON-GATED PENTAMERIC ION CHANNEL. Haidai Hu 1197-Pos Board B106 NOVEL MECHANISM OF CHANNEL GATING BY A RING OF RCK DO- MAINS. Hanzhi Zhang , Yaping Pan, Zhao Wang, Ming Zhou 1198-Pos Board B107 NMR STRUCTURE OF THE HUMAN KCNQ1 VOLTAGE-SENSING DO- MAIN. Keenan C. Taylor , Georg Kuenze, Hui Huang, Chuck R. Sanders 1199-Pos Board B108 USING FRET TO ELUCIDATE THE LIPID TRAFFICKING MECHANISM OF SP-B N AND C TERMINAL PEPTIDES IN COMPARISON WITH KL 4 . Kayla Kroning , Otonye Braide-Moncoeur 1200-Pos Board B109 MOLECULAR DYNAMICS SIMULATIONS REVEAL THE ROLE OF MEMBRANE CHOLESTEROL DURING PORE FORMING PATHWAY OF CYTOLYSIN A.  Amit Behera , K. Ganapathy Ayappa 1201-Pos Board B110 IMPROVED PURIFICATION AND CRYSTAL FORMATION OF NATIVE MUS- CLE-TYPE NACHR USING MABS. Rafael Maldonado-Hernández , Claudia Silva, Adriana Pastrana, Claude Maysonet, José Lasalde

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