Biophysical Society 62nd Annual Meeting | Program Guide

1444-Pos Board B353 GCAMP CALCIUM IMAGING REVEALS KINETICS AND LOCATION OF MET CHANNELS IN MAMMALIAN SEMICIRCULAR CANAL HAIR CELLS.  Holly A. Holman , Micah D. Frerck, Richard D. Rabbitt 1445-Pos Board B354 FAST DECAY VARIANTS OF RED FLUORESCENT GENETICALLY-ENCODED CALCIUM INDICATORS. Silke Kerruth , Catherine Coates, Katalin Török 1446-Pos Board B355 THE BRIGHT CALBRYTE 520 ENABLES THE PROBENECID-FREE INTRACEL- LULAR CALCIUM ASSAYS. Qin Zhao , Muhua Yang, Haitao Guo, Ruogu Peng, Jinfang Liao, Zhenjun Diwu Intracellular Calcium Channels and Calcium Sparks and Waves II (Boards B356–B372) 1447-Pos Board B356 IMPROVED CALCIUM HANDLING IN HUMAN INDUCED PLURIPOTENT STEM CELL CARDIOMYOCYTES. Daniel Blackwell , Shan S. Parikh, Nieves Gomez-hurtado, Bjorn C. Knollmann 1448-Pos Board B357 TRPV4 INCREASES CARDIOMYOCYTE CALCIUM TRANSIENTS AND CON- TRIBUTES TO CARDIAC DAMAGE FOLLOWING ISCHEMIA-REPERFUSION IN HEARTS OF AGED MICE. Deborah Peana , John L. Jones, Adam B. Veteto, Michelle D. Lambert, Timothy L. Domeier 1449-Pos Board B358 EARLY DIASTOLIC CA 2+ SPARKS ALTER REPOLARIZATION RATE OF RABBIT CARDIOMYOCYTES. Priyanka Saxena, Godfrey Smith, Niall Macquaide 1450-Pos Board B359 RE-TRIGGERABILITY OF CA 2+ SPARKS FOLLOWING EVOKED CA 2+ RE- LEASE. Ewan D. Fowler , Cherrie HT Kong, Jules C. Hancox, Mark B. Cannell 1451-Pos Board B360 SUBCELLULAR CALCIUM EVENTS AND CALCIUMWAVES IN LEG SKEL- ETAL MUSCLE FIBERS ISOLATED FROM THE HONEY BEE APIS MEL- LIFERA . Claude Collet, Cecilia Simut, Marianna Takacs, Laszlo Szabo, Peter Szentesi, László Csernoch 1452-Pos Board B361 THE FUNCTIONAL SIGNIFICANCE OF CARDIAC SERCA DIMERIZATION.  Elisa Bovo , Siddharth Bhayani, Roman Nikolaienko, Daniel Kahn, Seth Robia, Aleksey Zima 1453-Pos Board B362 SARCOPLASMIC RETICULUM CALCIUM LEAK IN CARDIOMYOCYTES: A CONTRIBUTION OF TRPC1 CHANNELS. Azmi A. Ahmad, Chris Hunter, Frank B. Sachse 1454-Pos Board B363 DOWNREGULATION OF NCX AND RYR DRIVES CHANGES IN COMPLE- MENTARY CHANNELS TO REGULATE CALCIUM TRANSIENTS IN CULTURED NEONATAL VENTRICULAR MYOCYTES. Esteban Vazquez-Hidalgo , Paul Paolini, Parag Katira 1455-Pos Board B364 PROTEIN PHOSPHATASE-1 MODULATES BASAL SPONTANEOUS BEATING RATE OF SINOATRIAL NODE CELLS (SANC). Tatiana M. Vinogradova , Ihor Zahanich, Yevgeniya O. Lukyanenko, Syevda Sirenko, Daniel R. Riordon, Kirill V. Tarasov, Yue Li, Alexey E. Lyashkov, Dongmei Yang, Edward G. Lakatta 1456-Pos Board B365 SPECIES DIFFERENCES OF CALCIUM CLOCK FUNCTIONS IN HUMAN, RAB- BIT AND MOUSE PACEMAKER CELLS RECAPITULATE SPECIES DIFFERENCES IN HEART RATE. Syevda Sirenko , Kenta Tsutsui, Bruce D. Ziman, Oliver J. Monfredi, Victor A. Maltsev, Edward G. Lakatta

1457-Pos Board B366 ACTION POTENTIAL SHORTENING PREVENTS ATRIAL CALCIUM ALTER- NANS. Giedrius Kanaporis , Jaime DeSantiago, Zane M. Kalik, Kathrin Banach, Lothar A. Blatter 1458-Pos Board B367 CONNEXIN-43-HEMICHANNEL-MEDIATED ATP EFFLUX TRIGGERS AR- RHYTHMOGENIC CA 2+ WAVES VIA P2X PURINOCEPTOR CURRENT IN ATRIAL MYOCYTES. Joon-Chul Kim, Min-Jeong Son, Qui Anh Le, Sun-Hee Woo 1459-Pos Board B368 INTERCELLULAR ULTRAFAST CALCIUMWAVE VELOCITY AND PROPAGA- TION OF SPONTANEOUS ELECTRICAL ACTIVITY IN A7R5 CELLS AT PHYSI- OLOGICAL TEMPERATURE.  Jairo C. Quijano , Teddy Grand, Stephan Rohr, Jean Jacques Meister 1460-Pos Board B369 EXCITATION-CONTRACTION COUPLING IN HFPEF. Peter Kilfoil , Xin Yue, Rui Zhang, Ryan Solymani, Daniel Soetkamp, Eduardo Marbán, Joshua Goldhaber 1461-Pos Board B370 TRIGGER VERSUS SUBSTRATE: MULTI-SCALE CONSIDERATIONS FOR AR- RHYTHMIA MODULATION BY PHARMACOLOGICAL ACTION.  Michael A. Colman , Erick A. Perez Alday, Arun V. Holden, Al P. Benson 1462-Pos Board B371 CELLSPECKS: A SOFTWARE FOR AUTOMATED DETECTION AND ANALYSIS FOR CALCIUM CHANNELS IN LIVE CELLS. Syed Islamuddin Shah , Martin Smith, Ian Parker, Ghanim Ullah, Angelo Demuro 1463-Pos Board B372 RELEVANCE OF INSP3 RECEPTOR ROS REGULATION IN ATRIAL MYO- CYTES.  Jaime Desantiago , Kathrin Banach Voltage-gated K Channels and Mechanisms of Voltage Sensing and Gating II (Boards B373–B392) 1464-Pos Board B373 DYNAMIC REARRANGEMENT OF THE INTRINSIC LIGAND REGULATES GATING OF KCNH POTASSIUM CHANNELS. Gucan Dai , Zachary M. James, William N. Zagotta 1465-Pos Board B374 A NOVEL HERG 1A/1B STABLE CELL LINE FOR DRUG SCREENING AND RESEARCH APPLICATIONS. Erick B. Ríos Pérez , Fang Liu, Whitney Stevens- Sostre, Gail A. Robertson 1466-Pos Board B375 I KR ENHANCEMENT IN STEM CELL-DERIVED CARDIOMYOCYTES BY MORPHOLINO ANTI-SENSE OLIGONUCLEOTIDES. Mark W. Nowak, Brian K. Panama, Qiuming Gong, Sanjot Singh, Randall Rasmusson, Zhengfeng Zhou, Glenna C L Bett 1467-Pos Board B376 MODELS OF HERG BLOCK. Brandon Franks , Glenna C L Bett, Randall Rasmusson 1468-Pos Board B377 EXTERNAL PROTONS ACCELERATE DEACTIVATION OF HERG CHANNELS BY DESTABILIZING THE RELAXED STATE OF THE VOLTAGE-SENSOR. Yu Shi, Samrat Thouta, Tom Claydon 1469-Pos Board B378 DIVALENT IONS AND H + BLOCK THE CARDIAC POTASSIUM CHANNEL HERG AT AN OUTER PORE SITE. Gagandeep Singh, Kavaldeep Singh, Souad Hamade, Alan Miller

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