Biophysical Society 62nd Annual Meeting | Program Guide

1546-Pos Board B455 IDENTIFICATION OF HYPEREKPLEXIA MUTATIONS THAT IMPAIR THE HOMOPENTAMERIC ASSEMBLY OF THE GLYCINE RECEPTOR GLYRA1. Anke Dopychai , Simone Heidenreich, C. Flore Pokam, Günther Schmalzing 1547-Pos Board B456 ATOMISTIC SIMULATION OF LIPID MEMBRANE PERMEATION FOR CAR- DIAC ION CHANNEL BLOCKERS. Kevin R. DeMarco , Slava Bekker, Colleen E. Clancy, Sergei Y. Noskov, Igor Vorobyov 1548-Pos Board B457 GABA A RECEPTOR SUBTYPE SELECTIVITY OF THE PROCONVULSANT RO- DENTICIDE TETS. Brandon Pressly , Hai Minh Nguyen, Heike Wulff 1549-Pos Board B458 VALIDATION OF AN AUTOMATED PATCH-CLAMP SCREENING ASSAY ON HUMAN KIR2.1 CARDIAC ION CHANNELS. Georg Andrees Bohme , Camille Sanson, Brigitte Schombert, Michel Partiseti 1550-Pos Board B459 TRANSCRIPTIONAL PROFILES AND K + CHANNELS DIFFER IN RAT AND MOUSE PRIMARY MICROGLIA IN RESPONSE TO PRO- AND ANTI-INFLAM- MATORY STIMULI. Starlee Lively, Doris Lam, Lyanne C. Schlichter 1551-Pos Board B460 ROLE OF RYANODINE RECEPTOR CHANNEL AND MECHANISMS OF VAS- CULAR DISEASES. Yun-Min Zheng, Yong-Xiao Wang 1552-Pos Board B461 CHANGES IN I KR amPLITUDE (NOT GATING) IS THE KEY DETERMINANT FOR VENTRICULAR ACTION POTENTIAL PROLONGATION. Don E. Burgess , Jen- nifer L. Smith, Ahmad S. amin, Corey L. Anderson, Craig T. January, Brian P. Delisle Cardiac Muscle Mechanics and Structure I (Boards B462–B480) 1553-Pos Board B462 HYPERTROPHIC CARDIOMYOPATHY: VARIABLE EXPRESSION OF MYOSIN- BINDING PROTEIN C FROM CELL-TO-CELL AND FUNCTIONAL IMBALANCE amONG INDIVIDUAL CARDIOMYOCYTES. David Aldag-Niebling, Ante Ra- docaj, Denise Hilfiker-Kleiner, Cristobal dos Remedios, Bernhard Brenner, Theresia Kraft 1554-Pos Board B463 HIGH-THROUGHPUT FUNCTIONAL SCREENING ASSAY OF FORCE AND STIFFNESS IN IPSC DERIVED CARDIOMYOCYTES. Ricardo Serrano , Wesley Lawrence McKeithan, Mark Mercola, Juan Carlos del Álamo 1555-Pos Board B464 STABLE MICROTUBULES PROVIDE VISCOELASTIC RESISTANCE TO CARDIO- MYOCYTE LENGTH CHANGE. Matthew A. Caporizzo , Christina Y. Chen, Alexander K. Salomon, Kenneth Bedi, Kenneth B. Margulies, Benjamin L. Prosser 1556-Pos Board B465 A NOVEL MOUSE MODEL FOR TITIN-BASED DILATED CARDIOMYOPA- THY. Eyad Nusayr , Joshua Strom, Rebecca E. Slater, Henk L. Granzier 1557-Pos Board B466 LOCATION OF HYPERTROPHIC CARDIOMYOPATHY-CAUSING TROPONIN T MUTATIONS DETERMINES DEGREE OF MYOFILAMENT DYSFUNC- TION. Maike Schuldt , Jamie R. Johnston, Michelle Michels, Diederik W.D. Kuster, José R. Pinto, Jolanda van der Velden 1558-Pos Board B467 TITIN VARIANTS IN GENETIC MYOPATHIES AND CARDIOMYOPATHIES- STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF PATHOGENIC MUTATIONS. Roksana Nikoopour , Martin Rees, Mark Pfuhl, Ana Ferreiro, Perry Elliott, Mathias Gautel

1559-Pos Board B468 ISCHEMIC CARDIOMYOPATHY PERTURBS GSK-3Β LOCALIZATION TO THE MYOFILAMENT TO REDUCE FUNCTION. Marisa J. Stachowski, Maria Papadaki, Jody L. Martin, Christine S. Moravec, Jonathan A. Kirk 1560-Pos Board B469 ENGINEERED THIN FILAMENT MUTATIONS TO STUDY THE SARCOMERE LENGTH DEPENDENCE OF CARDIAC MUSCLE CONTRACTILITY.  Joseph D. Powers , Farid Moussavi-Harami, Jil C. Tardiff, Jennifer Davis, Michael Regnier 1561-Pos Board B470 THE OFF STATE OF THE THICK FILAMENT OF CARDIAC MUSCLE IS NOT AF- FECTED BY INOTROPIC INTERVENTIONS LIKE THE INCREASE IN DIASTOLIC SARCOMERE LENGTH OR THE ADDITION OF A BETA-ADRENERGIC EFFEC- TOR. Vincenzo Lombardi , Francesca Pinzauti, Marco Caremani, Joseph Powers, Serena Governali, Massimo Reconditi, Theyencheri Narayanan, Ger J. M. Stienen, Marco Linari, Gabriella Piazzesi 1562-Pos Board B471 Education Travel Awardee MECHANICAL AND STRUCTURAL ANALYSIS OF CARDIOMYOPATHIES AT THE SINGLE CELL LEVEL. Paige E. Cloonan , Lina Greenberg, Michael J. Greenberg 1563-Pos Board B472 THE MISSENSE E258K-MYBP-C MUTATION INCREASES THE ENERGY COST OF TENSION GENERATION IN BOTH VENTRICULAR AND ATRIAL TISSUE FROM HCM PATIENTS. Giulia Vitale , Francesca Gentile, Nicoletta Piroddi, Beatrice Scellini, Josè Manuel Pioner, Iacopo Olivotto, Cecilia Ferrantini, Chiara Tesi, Corrado Poggesi 1564-Pos Board B473 CHRONIC EXERCISE INCREASES COMPLIANT TITIN AND KETTIN ISO- FORM CONTENT IN CARDIAC MUSCLE OF RAT AND DROSOPHILA MODELS. Mark Hiske, Deena Damschroder, Rober J. Wessells, Patrick J. Mueller, Charles S. Chung 1565-Pos Board B474 CARDIOSKELETAL DEFECTS IN R58Q-RLC MOUSE MODEL OF HCM.  Katarzyna Kazmierczak , Jingsheng Liang, Zhiqun Zhou, Sunil Yadav, Aldrin V. Gomes, Danuta Szczesna-Cordary 1566-Pos Board B475 DELETION OF CALPONIN 2 ATTENUATES THE DEVELOPMENT OF CALCIFIC AORTIC VALVE DISEASE. Olesya Plazyo , Jian-Ping Jin 1567-Pos Board B476 THE ACTC M305L HYPERTROPHIC CARDIOMYOPATHY MUTATION RESULTS IN HYPERCONTRACTILITY AND IMPAIRED RELAXATION OF DROSOPHILA MUSCLES. Meera C. Viswanathan, William Schmidt, Aditi Madan, Leah C. Sullivan, Christopher S. Newhard, Michael J. Rynkiewicz, William Lehman, Douglas M. Swank, Anthony Cammarato 1568-Pos Board B477 CARDIAC THIN FILAMENT-MEDIATED CALCIUM SENSITIZATION MODU- LATES CROSS-BRIDGE KINETICS. Maicon Landim-Vieira, David Gonzalez- Martinez, Jamie R. Johnston, Weikang Ma, Olga Antipova, Omar Awan, P. Bryant Chase, Thomas Irving, Jose R. Pinto 1569-Pos Board B478 CHARACTERIZATION OF A FLUORESCENT LEVOSIMENDAN ANALOG BINDING TO CARDIAC TROPONIN. Brittney Klein , Brian D. Sykes 1570-Pos Board B479 REGULATED MODEL OF STEADY-STATE CARDIAC LENGTH-DEPENDENT ACTIVATION. Timothy Alcid , William C. Hunter 1571-Pos Board B480 UNDERSTANDING CALCIUM SENSITIZATION AND DESENSITIZATION US- ING A CARDIAC TROPONIN CHIMERA. Fangze Cai , Peter Hwang, Brian Sykes

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