Biophysical Society 63rd Annual Meeting | Program Guide

Platform Exocytosis & Endocytosis 10:45 am - 12:45 pm, Room 309/310

1534-Plat 12:15 pm DYNAMIC INTERACTIONS BETWEEN A DISORDERED PROTEIN AND ITS TARGET AT THE SINGLE-MOLECULE LEVEL.  Spencer Smyth , Gregory-Neal Gomes, Claudiu C. Gradinaru, Julie D. Forman-Kay 1535-Plat 12:30 pm SURVEYING THE SEQUENCE SPACE LANDSCAPE OF FOLD-SWITCHING PROTEINS.  Lauren L. Porter , Loren L. Looger Platform Voltage-gated Na and Ca Channels 10:45 am - 12:45 pm, Room 307/308 Co-Chairs Hui Xu, Genentech Manu Ben-Johny, Columbia University 1536-Plat 10:45 am STRUCTURAL BASIS OF NAV1.7 INHIBITION BY THE TARANTULA TOXIN PROTOXIN-II.  Hui Xu , Tianbo Li, Alexis Rohou, Christopher Arthur, Foteini Tzakoniati, Evera Wong, Alberto Estevez, Christine Kugel, Yvonne Franke, Jun Chen, Claudio Ciferri, David Hackos, Christopher Koth, Jian Payandeh 1537-Plat 11:00 am FENESTRATION DIFFERENCES IN OPEN AND CLOSED GATE SODIUM CHANNELS: A MOLECULAR BASIS FOR STATE-DEPENDENT DRUG DESIGN.  Altin Sula , Giulia Montini, Jennifer Booker, Bonnie A. Wallace 1538-Plat 11:15 am SELECTIVE DE-ADHESION WITHIN INTERCALATED DISK NANODOMAINS PROMPTS PROARRHYTHMIC CONDUCTION SLOWING IN THE HEART.  Heather L. Struckman , Louisa Mezache, Amara Greer-Short, Anna Phil- lips, Thomas J. Hund, Rengasayee Veeraraghavan 1539-Plat 11:30 am BIOCHEMICAL AND FUNCTIONAL EVIDENCE FOR HOMODIMERIZATION OF VOLTAGE-GATED SODIUM CHANNELS (NAVS).  Guenther Schmalzing , Silvia Detro-Dassen, Nikolay Bebrivenski, Annika Rühlmann, Angelika Lampert 1540-Plat 11:45 am TIMOTHY SYNDROME-ASSOCIATED MUTATIONS AFFECT STATE-DEPEN- DENT CONTACTS IN L-TYPE CALCIUM CHANNEL.  Vyacheslav S. Korkosh, ArtemM. Kisilev, Eugeniy N. Mikhaylov, Anna A. Kostareva, Boris S. Zhorov 1541-Plat 12:00 pm CHARACTERIZATION OF ARRHYTHMIA MUTATIONS IN CALMODULIN AND THEIR INTERACTIONS WITH THE VOLTAGE-GATED CALCIUM CHANNEL.  Kaiqian Wang , Christian Holt, Jocelyn Lu, Malene Brohus, Kamilla T. Larsen, Michael T. Overgaard, Reinhard Wimmer, Filip Van Petegem 1542-Plat 12:15 pm CA V 1.3 REJECTS SIGNALING FROM A SECOND CAM IN ELICITING CA 2+ - DEPENDENT FEEDBACK REGULATION.  Nourdine Chakouri , Johanna Diaz, Manu Ben-Johny 1543-Plat 12:30 pm INACTIVATION REGULATES RGK-MEDIATED INHIBITION OF VOLTAGE-GAT- ED CALCIUM CHANNELS.  Zafir Buraei , Rose Levenson-Palmer, Scott Dob- bins, Zuleen Chia Chang, Sukhjinder Kaur, Salma Allam, Bryan Cernuda, Gabrielle Suppa, Jian Yang

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Co-Chairs Jonas Ries, EMBL, Germany Zachary McDargh, Columbia University 1544-Plat 10:45 am

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HIGH-THROUGHPUT SUPERRESOLUTION MICROSCOPY OF ENDOCYTOSIS - LINKING MOLECULAR ARCHITECTURE AND MECHANICS OF A PROTEIN MACHINERY. Markus Mund, Johannes van der Beek, Joran Deschamps, Philipp Hoess, Serge Dmitrieff, Francois Nedelec, Marko Kaksonen, Jonas Ries 1545-Plat 11:00 am SELF-ORGANIZATION AND FORCE PRODUCTION BY THE BRANCHED ACTIN CYTOSKELETON DURING MAMMALIAN CLATHRIN-MEDIATED ENDOCYTOSIS. Matthew Akamatsu, Ritvik Vasan, David G. Drubin, Daniel Serwas, Padmini Rangamani 1546-Plat 11:15 am ROLE OF MEMBRANE REMODELING PROTEINS IN ULTRAFAST ENDOCY- TOSIS.  Sumana Raychaudhuri , Eduardo Sandoval, Shigeki Watanabe 1547-Plat 11:30 am TRAVEL AWARDEE INVESTIGATING MEMBRANE TENSION DYNAMICS IN THE NEURONAL PRESYNAPTIC TERMINAL.  Natasha Dudzinski , David Zenisek, Erdem 11:45 am OSMOTIC SQUEEZING AND MEMBRANE TENSION DRIVE VESICLE EVOLU- TION DURING EXOCYTOSIS.  Rui Su , Sathish Thiyagarajan, Wonchul Shin, Ling-Gang Wu, Ben O’Shaughnessy 1549-Plat 12:00 pm TRAVEL AWARDEE TWO POPULATIONS OF INSULIN GRANULES WITH DISTINCT FUSION PROPERTIES ARE MAINTAINED BY ABC TRANSPORTERS ABCG1 AND ABCA1.  Noah A. Schenk , Alex J.B. Kreutzberger, Megan T. Harris, Cath- erine A. Doyle, Patrick Seelheim, Binyong Liang, Volker Kiessling, Arun Anantharam, Lukas K. Tamm, J. David Castle 1550-Plat 12:15 pm FUSION PORE REGULATION BY EPAC2/CAMP CONTROLS CARGO RELEASE DURING INSULIN EXOCYTOSIS.  Alenka Gucek , Nikhil R. Gandasi, Muhm- mad Omar-Hmeadi, Marit Bakke, Stein Doskeland, Anders Tengholm, Sebastian Barg 1551-Plat 12:30 pm SNARE-MEDIATED MEMBRANE FUSION IS A TWO-STAGE PROCESS DRIVEN BY ENTROPIC FORCES.  Zachary A. McDargh , Anirban Polley, Ben O’Shaughnessy Platform Biosensors 10:45 am - 12:45 pm, Room 314/315 Co-Chairs Bohdana Discher, University of Pennsylvania Sonja Schmid, Delft University of Technology, The Netherlands 1552-Plat 10:45 am A MOLECULAR SENSOR REVEALS DIFFERENCES IN MACROMOLECULAR CROWDING BETWEEN THE CYTOPLASM AND NUCLEOPLASM.  Chan- drashekhar Murade, George T. Shubeita Karatekin 1548-Plat

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