Biophysical Society 63rd Annual Meeting | Program Guide

1867-Pos Board B230 FORCE-INDUCED UNFOLDING OF A MECHANOSENSORY DOMAIN IN PLATELET GLYCOPROTEIN (GP)IB-IX UNDER SOLUTION AND ADHERENT CONDITIONS. M. Edward Quach , Dale Combs, Khalid Salaita, Renhao Li 1868-Pos Board B231 DESMIN IS CRITICAL TO THE NUCLEAR ARCHITECTURE OF CARDIOMYO- CYTES. Patrick Robison , Julie Heffler, Rajan Jain, Benjamin Prosser 1869-Pos Board B232 TRAVEL AWARDEE BILE CANALICULI CONTRACTILITY IS REGULATED BY CANALICULAR PRES- SURE SENSING VIA PIEZO1. Kapish Gupta , Inn Chuan Ng, Boon C. Low, Board B233 MYOSIN-II MEDIATED TRACTION FORCES EVOKE LOCALIZED PIEZO1 CA 2+ FLICKERS. Kyle L. Ellefsen, Alice Chang, Jamison L. Nourse, Jesse R. Holt, Janahan Arulmoli, Armen Mekhdjian, Hamid Aburwarda, Francesco Tom- bola, Lisa A. Flanagan, Alexander R. Dunn, Ian Parker, Medha M. Pathak 1871-Pos Board B234 CHOLESTEROL-DEPENDENT PIEZO1 CLUSTERS ARE ESSENTIAL FOR EFFI- CIENT CELLULAR MECHANOTRANSDUCTION. Pietro Ridone, Elvis Pandzic, Massimo Vassalli, Charles D. Cox, Alex M. Macmillan, Philip A. Gottlieb, Boris Martinac 1872-Pos Board B235 TRAVEL AWARDEE FORCE-DEPENDENT CONFORMATIONAL CHANGES IN THE MECHANO- SENSITIVE PIEZO1 CHANNEL. Alper D. Ozkan , Jerome J. Lacroix 1873-Pos Board B236 VOLTAGE DEPENDENCE AND MODULATION OF BACTERIAL CHANNEL MSCL.  Joseph S. Najem , Ian Rowe, Andriy Anishkin, Joseph Maramba, Donald J. Leo, Sergei Sukharev 1874-Pos Board B237 DELETION OF MSCL IN VIBRIO CHOLERAE (C6706) INCREASES OSMOTIC VIABILITY THROUGH OVEREXPRESSION OF MSCS AND SUGGESTS A SPECIAL CROSSTALK MECHANISM IN MECHANOSENSITIVE CHANNEL REGULATION. Madolyn Britt 1875-Pos Board B238 MECHANICS, STRUCTURE, AND ENERGETICS OF MSCL THROUGH LOCAL STRESS CALCULATIONS AND STEERED MD SIMULATIONS.  Juan M. Vanegas , Rajitha R. Tatikonda 1876-Pos Board B239 EVOLUTIONARY SPECIALIZATION OF CORYNEBACTERIUM GLUTAMICUM MSCCG, AN MSCS-LIKE MECHANOSENSITIVE CHANNEL, IN GLUTAMATE EXPORT. Yoshitaka Nakayama , Kosuke Komazawa, Navid Bavi, Ken-ichi Hashimoto, Hisashi Kawasaki, Boris Martinac 1877-Pos Board B240 PHYSIOLOGICAL ROLE OF BACTERIAL- LIKE MECHANOSENSITIVE CHAN- NELS IN PROTOZOAN PARASITES. Noopur Dave, Monica Hernandez, Tiffine Pham, Megna Tiwari, Heather Lynch, Joshua Fonbuena, Kristy Nguyen, Veronica Jimenez 1878-Pos Board B241 THE BACTERIAL MECANOSENSITIVE CHANNEL MSCL AS A NOVEL ANTIBI- OTIC TARGET.  Irene Iscla , Robin Wray, Paul Blount 1879-Pos Board B242 ELUCIDATING THE MOLECULAR BASIS OF PH-TRIGGERED ACTIVATION OF AN ENGINEERED MECHANOSENSITIVE CHANNEL. Kalyan Immadisetty, Reid Shelton, Mahmoud Moradi 1880-Pos Board B243 FORCE LOADING DURING MECHANOSENSING EMERGES FROM NON- MECHANOSENSITIVE ACTIVE DISPLACEMENTS. Lea Feld, Ariel Livne, Yuri Lubomirsky, Abhishek Mukherjee, Eran Bouchbinder, Haguy Wolfenson Hanry Yu 1870-Pos

1854-Pos Board B217 MOLECULAR SIMULATION AND CONTINUUMMODELING OF N-BAR- INDUCED LIPID MEMBRANE DEFORMATIONS. Andrew H. Beaven , Alexander J. Sodt 1855-Pos Board B218 MOLECULAR AND CONTINUUMMODELING METHODS FOR UNDER- STANDING THE ROLE OF POLYPHOSPHOINOSITIDES IN INDUCING CELLULAR MORPHOLOGY CHANGES. Ryan Bradley , David Slochower, Ololade Fatunmbi, Sreeja Kutti Kandy, Robert Bucki, Paul A. Janmey, Ravi Radhakrishnan 1856-Pos Board B219 A PARTIALLY CLOSED STATE IN NHTMEM16 SCRAMBLASE IS ENABLED BY LIPID TAIL INSERTION INTO THE PROTEIN GROOVE. George Khelashvili , Maria Falzone, Xiaolu Cheng, Alessio Accardi, Harel Weinstein 1857-Pos Board B220 THE OUTER MEMBRANE PROTEINS OMPA, FHUA, OMPF, ESTA, BTUB AND OMPX HAVE UNIQUE LIPOPOLYSACCHARIDE FINGERPRINTS.  Jonathan Shearer , Damien F. Jefferies, Syma Khalid 1858-Pos Board B221 A MOLECULAR MECHANISM FOR MEMBRANE GEOMETRY-SPECIFIC PRO- TEIN LOCALIZATION. Gabriele Kockelkoren Mechanosensation (Boards B222 - B244) 1859-Pos Board B222 A SYSTEMATIC STUDY OF CELL MECHANICS AND FUNCTION MODULATED BY NANOTOPOGRAPHY. Xiao Li , Lasse Klausen, Wei Zhang, Bianxiao Cui 1860-Pos Board B223 CELL-CELL ADHESION AND MYOSIN ACTIVITY REGULATE CORTICAL ACTIN ASSEMBLY IN MAMMARY GLAND EPITHELIUM ON CONCAVED SUR- FACE. Wei-Hung Jung , Khalid Elawad, Sung Hoon Kang, Yun Chen 1861-Pos Board B224 TRAVEL AWARDEE REGION-SPECIFIC STRETCH-INDUCED DISRUPTION OF CAVEOLAE DECREASES EXPRESSION OF MECHANOSENSITIVE CHLORIDE CHAN- NELS AND STIMULATES FIBROGENESIS PROMOTING ARRHYTHMOGENIC ATRIAL ECTOPY IN FAILING MICE. Zachary D. Piro , Rylie Lodin, Leonid Tyan, Evi Lim, Di Lang, Alexey V. Glukhov 1862-Pos Board B225 MICROTUBULE MECHANOTRANSDUCTION THROUGH NOX2-ROS INITI- ATES TRPV4 CALCIUM INFLUX AND PURINERGIC CALCIUM OSCILLATIONS THAT REGULATE OSTEOCYTE MECHANO-SENSING. Katrina M. Williams , Nicole Gould, Derek Jones, Ramzi Khairallah, Christopher W. Ward, Joseph P. Stains 1863-Pos Board B226 CLASSIFICATION OF DIFFERENT CANCER CELL TYPES BY SPECIES SPECIFIC- ITY FOR CELL ELASTICITY. Sangwoo Kwon , Se Jik Han, Kyung Sook Kim 1864-Pos Board B227 THE SWELL1-LRRC8 COMPLEX REGULATES ENDOTHELIAL PI3K-AKT2- GRB2-ENOS SIGNALING AND VASCULAR FUNCTION. Ahmad F. Alghanem , Chau Ta, Oluwaseun Adeola, Susheel K. Gunasekar, Urooj Fatima, Elliot- Hudson Elliot-Hudson, Yanhui Zhang, Megan Riker, Robert F. Mullins, Litao Xie, Rajan Sah 1865-Pos Board B228 AGE-DEPENDENT PLASTICITY OF SOMATOSENSORY MECHANOSENSA- TION. Niklas Michel , Pratibha Narayanan, Manuela Schmidt 1866-Pos Board B229 A FIRST STEP TOWARD UNDERSTANDING OBSCURIN’S MOLECULAR MECHANISM. Charles J. White , Shaston Newman, Daniel Conway, Na- than T. Wright

T U

E S

D A Y

114