Biophysical Society 63rd Annual Meeting | Program Guide

1881-Pos Board B244 BENDING-INDUCED STRAIN DELAYS COLLAGEN DEGRADATION BY COL- LAGENASE. Karanvir Saini , Manu Tewari, Jerome Irianto, Charlotte Pfeifer, Cory Alvey, Dennis E. Discher Intracellular Calcium Channels and Calcium Sparks and Waves (Boards B245 - B267) 1882-Pos Board B245 TRAVEL AWARDEE HIGH-THROUGHPUT SCREENING YIELDS ALLOSTERIC INHIBITORS OF LEAKY RYRS FOR THERAPEUTIC DEVELOPMENT. Robyn T. Rebbeck , Daniel P. Singh, Kenneth S. Ginsburg, Xiaoqiong Dong, David D. Thomas, Donald M. Bers, Bradley S. Launikonis, Razvan L. Cornea 1883-Pos Board B246 MACHINE LEARNING AND SUPER-RESOLUTION MICROSCOPY REVEAL DETAILED HIERARCHY OF RYANODINE RECEPTOR DISTRIBUTION IN CAR- DIAC PACEMAKER CELLS. Alexander V. Maltsev, Pooja Ajay Warrier , Oliver Monfredi, Magdalena Juhaszova, Edward G. Lakatta, Victor A. Maltsev, Michael D. Stern 1884-Pos Board B247 THE ROLE OF CYSTEINE 3602 IN RYR2 REGULATION BY CALMODULIN AND OXIDATIVE STRESS. Roman Nikolaienko , Elisa Bovo, Robyn T. Rebbeck, Donald M. Bers, Razvan L. Cornea, Aleksey V. Zima 1885-Pos Board B248 PACEMAKER ORGANIZATION AT THE NANOSCALE: IMAGING OF RY- ANODINE RECEPTORS AS CLUSTERS IN SINGLE SINOATRIAL NODAL CELLS. Maura Greiser , Humberto C. Joca, W. Jonathan Lederer 1886-Pos Board B249 ALCOHOL DECREASES THE ACTIVITY OF NATIVE RYANODINE RECEPTORS FROM RAT HEART. Yanping Ye, Logan Stewart, Kelsey North, Lie Wang, Alex M. Dopico 1887-Pos Board B250 IMPAIRED LIGAND REGULATION OF NATIVE RYR2 CHANNELS IN THE CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA MU- TATION, RYR2-V2475F(+/-). Abigail D. Wilson , Elisa Venturi, Charalampos Sigalas, Yuanlong Song, Carmen R. Valdivia, Héctor H. Valdivia, Ming Lei, Rebecca M. Sitsapesan 1888-Pos Board B251 EFFECT OF RYR2 EXPRESSION LEVEL ON ACTIVATION AND TERMINATION OF SPONTANEOUS CA-INDUCED CA RELEASE. Roman Nikolaienko, Elisa Bovo, Aleksey V. Zima 1889-Pos Board B252 TRAVEL AWARDEE STRUCTURAL DYNAMICS OF CALMODULIN IN REGULATION OF RYR CALCIUM RELEASE CHANNELS. Megan R. McCarthy , Robyn T. Rebbeck, Razvan L. Cornea, David D. Thomas 1890-Pos Board B253 DIFFERENT CONTEXT FOR SHEAR SIGNALING IN LEFT VERSUS RIGHT ATRIAL MYOCYTES: DIFFERENTIAL ROLES OF P2Y 1 - AND P2X 4 -PURINO- CEPTORS. Joon-Chul Kim, Min-Jeong Son, Qui A. Le, Kyoung-Hee Kim, Sun-Hee Woo 1891-Pos Board B254 THE BINDING INTERACTIONS THAT MAINTAIN THE EC COUPLING JUNC- TIONS IN SKELETAL MUSCLE. Eduardo Rios , Dirk Gillespie, Clara Franzini- Armstrong 1892-Pos Board B255 PHARMACOLOGICAL MODULATION OF MITOCHONDRIAL CA 2+ UPTAKE REGULATES SARCOPLASMIC RETICULUM CA 2+ RELEASE VIA OXIDATION OF RYANODINE RECEPTOR BY REACTIVE OXYGEN SPECIES. Shanna Hamilton , Radmila Terentyeva, Tae Yun Kim, Peter Bronk, Jin O-Uchi, Gyorgy Csor- das, Bum Rak Choi, Dmitry Terentyev

1893-Pos Board B256 SMALL ANKYRIN 1 INTERACTS WITH PHOSPHOLAMBAN TO REGULATE MUSCLE SERCA1. Amanda Labuza , Patrick F. Desmond, Allison E. Man- cini, Joaquin Muriel, Mark A. Rizzo, Robert J. Bloch 1894-Pos Board B257 TRPV4 CONTRIBUTES TO STRETCH-INDUCED HYPERCONTRACTILITY AND TIME-DEPENDENT DYSFUNCTION IN HEARTS OF AGED MICE. Adam B. Veteto , Michelle D. Lambert, Kerry S. McDonald, Tim L. Domeier 1895-Pos Board B258 IP 3 R1-MEDIATED LOCAL CA 2+ RELEASE EVENTS ARE ENHANCED IN THE GAIN-OF-FUNCTION D2594K MUTANT CHANNEL. Madeleine R. Mascitti, Karyn M. DiNovo, Michael Fill, S.R. Wayne Chen, Josefina Ramos-Franco, Rafael Mejia-Alvarez 1896-Pos Board B259 Β-ADRENERGIC PATHWAY IS ENHANCED BY HORMONE-INDUCED MATURATION OF HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES (IPS-CM). David Carreras , Rebecca Martinez-Moreno, Elisabet Selga, Ramon Brugada, Fabiana S. Scornik, Guillermo J. Perez 1897-Pos Board B260 EARLY AFTERDEPOLARIZATIONS AND ALTERNANS ARE THE UNDERLYING MECHANISM TO CAUSE ARRHYTHMOGENIC DISORDER IN THE MUTANT CALSEQUESTRIN 2 (CASQ2). Aman Ullah , Roshan Paudel, W. Jonathan Lederer, M. Saleet Jafri 1898-Pos Board B261 TRAVEL AWARDEE TRIGGERED CALCIUM EVENTS REVEAL ELECTROPHYSIOLOGICAL AL- TERATIONS IN A COHORT OF PATIENTS SUSCEPTIBLE TO MALIGNANT HYPERTHERMIA. Lourdes Figueroa , Natalia Kraeva, Carlo Manno, Eshwar R. Tammineni, Sheila Riazi, Eduardo Rios 1899-Pos Board B262 TRAVEL AWARDEE THE INTERPLAY BETWEEN NAADP AND PI(3,5)P2 IN THE ACTIVATION OF LYSOSOMAL TWO-PORE CHANNEL 2. Qiaochu Wang , Michael X. Zhu 1900-Pos Board B263 IOCBIO SPARKS DETECTION AND ANALYSIS SOFTWARE. Martin Laasmaa, Niina Karro, Rikke Birkedal, Marko Vendelin 1901-Pos Board B264 NON-RYR CALCIUM LEAK OF THE SARCOPLASMIC RETICULUM IS GOV- ERNED BY TRPC1 IN CARDIOMYOCYTES. Azmi A. Ahmad , Molly E. Streiff, Chris Hunter, Frank B. Sachse 1902-Pos Board B265 ACTIVATION OF ENDOGENOUS PP1 ENHANCES CALCIUM SPARK ACTIV- ITY IN WILD TYPE CARDIOMYOCYTES. Radoslav Janicek , Duilio Michele Potenza, Miguel Fernandez-Tenorio, Hector H. Valdivia, Ernst Niggli 1903-Pos Board B266 ABNORMAL GLUCOSE METABOLISM AND CALCIUM SIGNALING IN MA- LIGNANT HYPERTHERMIA (MHS) PATIENTS. Eshwar R. Tammineni , Carlos Ibarra, Lourdes Figueroa, Carlo Manno, Natalia Kraeva, Eduardo Rios, Sheila Riazi 1904-Pos Board B267 THE ANTI-CANCER DRUG VATALANIB (PTK787/ZK222584) SUPPRESSES NORMAL SPONTANEOUS FIRING OF RABBIT SINOATRIAL NODE CELLS (SANC). Tatiana M. Vinogradova , Kirill V. Tarasov, Yelena S. Tarasova, Edward G. Lakatta

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