Biophysical Society 63rd Annual Meeting | Program Guide

1933-Pos Board B296 PREDICTING VARIANT PATHOGENICITY IN THE CARDIAC SODIUM CHAN- NEL USING PARALOGUE ANNOTATION. Svetlana Tarnovskaya , Vyacheslav Korkosh, Boris S. Zhorov, Dmitrij Frishman 1934-Pos Board B297 CHRONIC EXPOSURE TO TUMOR NECROSIS FACTOR IN VIVO INDUCES HYPERALGESIA, UPREGULATES SODIUM CHANNEL GENE EXPRESSION AND ALTERS THE CELLULAR ELECTROPHYSIOLOGY OF DORSAL ROOT GAN- GLION NEURONS. Michael E. O’Leary , Andrea Bottaro, Igor Kuzin, Cojen Ho, Brad Fischer Ligand-gated Channels II (Boards B298 - B322) 1935-Pos Board B298 TRAVEL AWARDEE LOOP G OF THE GABAAR ORTHOSTERIC BINDING SITE IS INVOLVED BOTH IN BINDING AND GATING PROCESSES. Marek Brodzki , Michal A. Micha- lowski, Jerzy W. Mozrzymas 1936-Pos Board B299 EFFECT OF HYPERGLYCEMIA IN THE ACTIVITY OF GLYCINE RECEPTORS IN INSULIN SECRETING CELLS. Amanda Schukarucha Gomes , Silvana Bordin, Fernando Abdulkader 1937-Pos Board B300 TARGETED STATE DEPENDENT CROSSLINKING MASS SPECTROMETRY (CXMS) OF THE HUMAN ALPHA 1 GLYCINE RECEPTOR (GLYR). Kayce A. Tomcho , Hannah E. Gering, Rathna J. Veeramachaneni, David J. Lapinsky, Michael Cascio 1938-Pos Board B301 AROMATIC RESIDUES IN THE GLYCINE RECEPTOR TRANSMEMBRANE FORM A NETWORK REQUIRED FOR FUNCTION. Sarah C. Lummis , Bijun Tang 1939-Pos Board B302 PHARMACOLOGICAL SELECTIVITY OF A STEROID BINDING SITE AT THE BETA + -ALPHA - INTERFACE OF ALPHA1 BETA3 GABA-A RECEPTORS. Selwyn S. Jayakar , Xiaojuan Zhou, Bo Wu, Keith W. Miller, Karol S. Bruzik, Jona- than B. Cohen 1940-Pos Board B303 IDENTIFICATION OF A HIGH-AFFINITY NEUROSTEROID BINDING SITE IN HUMAN ALPHA1BETA3 GABA A R USING A PHOTOREACTIVE THDOC ANA- LOG. David C. Chiara , Bo Wu, Xiaojuan Zhou, Selwyn S. Jayakar, Katherine Titterton, Stuart A. Forman, Keith W. Miller, Karol S. Bruzik, Jonathan B. Cohen 1941-Pos Board B304 TRAVEL AWARDEE A COMPARISON BETWEEN HOMOMERIC AND HETEROMERIC 5-HT3 RECEPTORS IN RESPONSE TO THE ANTIDEPRESSANT BUPROPION. Antonia Stuebler , Michaela Jansen 1942-Pos Board B305 IN-VIVO AND IN-VITRO STUDIES TO IDENTIFY THE INTERACTION SITE OF THE INTRACELLULAR DOMAIN OF SEROTONIN TYPE 3A (5-HT 3A -ICD) AND CHAPERON PROTEIN RIC-3. Elham Pirayesh , Antonia G. Stuebler, Michaela Jansen 1943-Pos Board B306 MICROSECOND-SCALE MOLECULAR DYNAMICS SIMULATIONS REVEAL DESENSITIZED BEHAVIOR OF 5HT3. Nicholas B. Guros , Arvind Balijepalli, Jeffery B. Klauda 1944-Pos Board B307 LONG DISTANCE NMR RESTRAINTS FOR THE FLEXIBLE Á7NACHR INTRA- CELLULAR DOMAIN. Vasyl Bondarenko , Marta Wells, Qiang Chen, Tommy Tillman, Yan Xu, Pei Tang

1945-Pos Board B308 FUNCTIONAL TOLERANCE OF HUMAN Α7 NICOTINIC ACETYLCHOLINE RECEPTOR TO CYSTEINE LABELING. Tommy S. Tillman , Yan Xu, Pei Tang 1946-Pos Board B309 ROLE OF THE CYTOPLASMATIC M3-M4 LOOP FOR THE HOMOPENTAM- ERIC ASSEMBLY OF A CHIMERIC NICOTINIC ALPHA 7 RECEPTOR.  Jonas Deppe , Lena Hauswirth, Heike Lauks, Achim Kless, Ralf Hausmann, Guenther Schmalzing 1947-Pos Board B310 PROBABILITY OF OPENING DURING RECOVERY FROM ACETYLCHOLINE RECEPTOR DESENSITIZATION. Radhakrishnan Gnanasambandam , An- thony Auerbach 1948-Pos Board B311 TRAVEL AWARDEE STRUCTURE MEETS FUNCTION: AGONIST ACTIONS AT NEUROTRANSMIT- TER BINDING SITES. Sushree Tripathy , Wenjun Zheng, Anthony Auerbach 1949-Pos Board B312 A PHOTOACTIVATABLE NICOTINE FOR INTERROGATING NATIVE NACHRS AND CHOLINERGIC TRANSMISSION. Sambashiva Banala 1950-Pos Board B313 INTEGRATIVE STRUCTURE DETERMINATION OF Α7NACHR INTRACELLU- LAR DOMAIN. Marta M. Wells , Vasyl Bondarenko, Tommy S. Tillman, Kev- in Singewald, Matthew J. Lawless, Joel Caporoso, Nicole Brandon, Charles Chen, Monica N. Kinde, Sunil Saxena, Yan Xu, Erik Lindahl, Pei Tang 1951-Pos Board B314 TRAVEL AWARDEE STRUCTURE-ACTIVITY RELATIONSHIP OF POTENT PHOTO-SWITCHABLE NEUROMUSCULAR INHIBITORS. Clara Herrera-Arozamena , Martin H. Estrada-Valencia, Carlos A. Villalba-Galea, Maria Isabel Rodriguez-Franco 1952-Pos Board B315 IDENTIFYING STEROID BINDING SITES IN A NICOTINIC ACETYLCHOLINE RECEPTOR (NACHR) WITH A PHOTOREACTIVE ANALOG OF ALPHAXA- LONE. Zhiyi Yu , Pavel Y. Savechenkov, Karol S. Bruzik, Jonathan B. Cohen 1953-Pos Board B316 PROBING THE BINDING SITE(S) OF BUPROPION IN GLIC BY SITE-DIRECTED MUTAGENESIS. Akash Pandhare , R. Bryan Sutton, Michaela Jansen 1954-Pos Board B317 ALLOSTERIC POTENTIATION OF A LIGAND-GATED ION CHANNEL IS MEDIATED BY ACCESS TO A DEEP MEMBRANE-FACING CAVITY. Stepha- nie Heusser, Marie Lycksell, Xueqing Wang, Sarah McComas, Rebecca J. Howard, Erik Lindahl 1955-Pos Board B318 TRAVEL AWARDEE UNDERSTANDING THE CONFORMATIONAL DYNAMICS OF A PENTAM- ERIC LIGAND-GATED ION CHANNEL THROUGH MARKOV STATE MODEL- ING. Cathrine C. Bergh , Laura Orellana, Rebecca J. Howard, Erik Lindahl 1956-Pos Board B319 PHARMACOLOGICAL CHARACTERIZATION OF THE ZINC-ACTIVATED CHAN- NEL: A CYS-LOOP RECEPTOR GATED BY ZN 2+ , CU 2+ AND PROTONS. Nawid Madjroh , Anders A. Jensen, Paul A. Davies 1957-Pos Board B320 STRUCTURAL STUDIES OF THE GATING MECHANISM IN A PENTAMERIC LIGAND-GATED ION CHANNEL CONTAINING TWO ADDITIONAL N-TER- MINAL PERIPLASMIC DOMAINS. Marc H. Delarue , Haidai Hu, Rebecca J. Howard, Urska Rovsnik, Sirine Hlioui, Erik Lindahl

T U

E S

D A Y

117