Biophysical Society 63rd Annual Meeting | Program Guide

2617-Pos Board B289 SEC1/MUNC18-FAMILY PROTEINS CATALYZE DIRECTIONAL SNARE AS- SEMBLY BY TEMPLATING SNARE FOLDING AND ASSOCIATION. Junyi Jiao, Mengze He, Sarah Port, Baker Richard, Yonggang Xu, Hong Qu, Yujian Xiong, Yukun Wang, Huaizhou Jin, Travis Eisemann, Frederick M. Hugh- son, Yongli Zhang 2618-Pos Board B290 A MECHANISM FOR EXOCYTOTIC ARREST BY THE COMPLEXIN C-TERMI- NUS. Mazen Makke 2619-Pos Board B291 NSF-MEDIATED DISASSEMBLY OF ON- AND OFF PATHWAY SNARE COM- PLEXES AND INHIBITION BY COMPLEXIN. Ucheor B. Choi , Minglei Zhao, K. Ian White, Axel Brunger 2620-Pos Board B292 THE NUMBER OF SNARE COMPLEXES CHANGING CONFORMATION DUR- ING VESICLE FUSION. Ying Zhao , Qinghua Fang, Satyan Sharma, Shrutee Jakhanwal, Reinhard Jahn, Manfred Lindau 2621-Pos Board B293 FUSION PORE DYNAMICS AND SNARE COMPLEX MOBILITY. Satyan Sharma , Manfred Lindau 2622-Pos Board B294 THREE STAGES OF NEUROTRANSMITTER RELEASE: CA-TRIGGERED UN- CLAMPING, SNARE RING ASSEMBLY AND SNARE-MEDIATED MEMBRANE FUSION. Zachary A. McDargh , Anirban Polley, Ben O’Shaughnessy Membrane Receptors and Signal Transduction II (Boards B295 - B315) 2623-Pos Board B295 MONOMERS OF AMPA-TYPE GLUTAMATE RECEPTOR SUBUNITS DIFFUSE IN AND OUT OF SPINES; UNRAVELING BY SINGLE-MOLECULE TRACK- ING.  Jyoji Morise , Kenichi G.N. Suzuki, Ayaka Kitagawa, Yoshihiko Waka- zono, Kogo Takamiya, Taka A. Tsunoyama, Hiromu Takematsu, Akihiro Kusumi, Shogo Oka 2624-Pos Board B296 BINDING FREE ENERGY CALCULATIONS OF NMDA GLUTAMATE RECEP- TORS. Adithya Polasa , Dylan S. Ogden, Mahmoud Moradi 2625-Pos Board B297 STRUCTURAL CORRELATES OF AGONIST BINDING TO NEUROTRANSMIT- TER BINDING SITES. Sushree Tripathy, Stephen M. Muehlemann , Wenjun Zheng, Anthony Auerbach 2626-Pos Board B298 ROLE OF Β-GLUCAN STRUCTURE IN DECTIN-1 SIGNALING AND MULTI- MERIZATION IN INNATE FUNGAL IMMUNITY. Eduardo U. Anaya , Aaron K. Board B299 IMPORTANCE OF ORDERED ENVIRONMENT IN THE EARLY STAGE OF MAST CELL SIGNALING STUDIED BY IMAGING FLUORESCENCE CORRELA- TION SPECTROSCOPY. Nirmalya Bag , David A. Holowka, Barbara A. Baird 2628-Pos Board B300 NANOSCALE ORGANIZATION AND MOBILITY OF LIGANDS DIRECT T CELL ACTIVATION. Joschka Hellmeier, Viktoria Motsch, Rene Platzer, Andreas Karner, Johannes Preiner, Gerhard J. Schuetz, Johannes B. Huppa, Eva Sevcsik 2629-Pos Board B301 LIVE AND SIMULTANEOUS READOUT OF NFAT AND ERK ACTIVATION IN T CELLS REVEALS MULTIPLE DIMENSIONS OF TCR SIGNALING.  Jenny J. Y. Lin , Shalini T. Low-Nam, Steven A. Alvarez, Jay T. Groves Neumann 2627-Pos

2630-Pos Board B302 BEYOND THE TCR, ANTIGEN DISCRIMINATION IN T CELLS CONTINUES IN THE LAT:GRB2:SOS PROTEIN CONDENSATE. Shalini T. Low-Nam , Jenny JY Lin, Darren B. McAffee, Steven A. Alvarez, Scott D. Hansen, Kole T. Roybal, Jay T. Groves 2631-Pos Board B303 TRAVEL AWARDEE A MEMBRANE-ACTIVATED, UNIVERSAL T-CELL RECEPTOR AGONIST.  Kiera B. Wilhelm , Michael P. Coyle, Geoffrey P. O’Donoghue, Jenny JY Lin, Shalini T. Low-Nam, Jay T. Groves 2632-Pos Board B304 SINGLE PMHC:TCR BINDING EVENTS PRECIPITATE LAT ASSEMBLIES CA- PABLE OF SPATIALLY DECOUPLING FROM THE ORIGINATING LIGAND.  Darren B. McAffee , Shalini T. Low-Nam, Jenny JY Lin, Steven A. Alvarez, Scott D. Hansen, Jay T. Groves 2633-Pos Board B305 MECHANICAL RESPONSES OF CANCER CELLS TO DIFFERENT MATRICES MEASURED BY AFM AND FRET. Fang Tian , Tsung-Cheng Lin, Liang Wang, Sidong Chen, Jun Chu, Ching-Hwa Kiang, Hyokeun Park 2634-Pos Board B306 COMPUTATIONAL MODEL OF RGD-CONTAINING COMPUTATIONAL MODEL OF RGD-CONTAINING PEPTIDES AND THEIR EFFECTS ON INTEG- RIN BINDING. Tamara C. Bidone, Aravind Rammohan, Matt McKenzie , Gregory A. Voth 2635-Pos Board B307 TOTAL RECONSTITUTION OF RECEPTOR-MEDIATED RAS ACTIVATION BY SOS IN VITRO REVEALS KINETIC AND CONFORMATIONAL LAYERS OF REGULATION IN MAPK SIGNALING . Steven Alvarez , William Y. C. Huang, Hiu Yue Monatrice Lam, Shalini T. Low-Nam, Young Kwang Lee, Jean K. Chung, Scott D. Hansen, Yasushi Kondo, Kabir H. Biswas, John Kuriyan, Jay Board B308 CANCER CELL HAS LOWERED THRESHOLD OF SIGNALING TRANSDUCTION EXCITABLE NETWORK CONTROLLED BY PIP-RAS INTERACTION. David Huiwang Zhan 2637-Pos Board B309 DYNAMIC PARTITIONING AND CONVECTION: A NEWMECHANISM FOR THE SELF-ORGANIZATION PATTERN OF THE EXCITABLE CORTICAL WAVES? Tatsat Banerjee , Yuchuan Miao, Debojyoti Biswas, Pablo A. Iglesias, Peter N. Devreotes 2638-Pos Board B310 QUANTIFICATION OF G1-CYCLIN DYNAMICS IN YEAST BY SCANNING NUMBER AND BRIGHTNESS. Savanna Dorsey, Pooja Goswami , Jing Cheng, Yogitha Thattikota, Sylvain Tollis, Catherine A. Royer, Mike Tyers 2639-Pos Board B311 RHOA MEDIATED JUXTACRINE REGULATION OF GLUCAGON SECRE- TION. Yong Hee Chung , David W. Piston 2640-Pos Board B312 PROTEIN KINASE A DYNAMICS ARE ALTERED AT THE OUTER MITOCHON- DRIAL MEMBRANE IN CARDIAC SYMPATHETIC NEURONS FROM PREHY- PERTENSIVE RATS. Dan Li , Adib Tarafdar, Kun Liu, David J. Paterson 2641-Pos Board B313 ROLE OF STORE OPERATED CALCIUM CHANNEL COMPLEX IN THE IN- FLAMMATORY SIGNALING IN PERIPHERAL SENSORY NEURONS. Alexandra S. Hogea, Shihab Shah, Nikita Gamper 2642-Pos Board B314 MECHANISTIC CHARACTERIZATION OF THE E102Q MUTATION IN THE SIGMA 1 RECEPTOR. Hideaki Yano , Ara M. Abramyan, Sett Naing, Leanne Liu, Lei Shi T. Groves 2636-Pos

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