Biophysical Society 63rd Annual Meeting | Program Guide

91-Plat TRAVEL AWARDEE DECIPHERING THE MECHANISM OF FORCE DISSEMINATION THROUGH TIP-LINKS IN HEARING.  Jagadish P. Hazra , Nisha Arora, Sabyasachi Rak- shit 92-Plat 9:45 am STRUCTURE DETERMINATION OF ACTIVE FULL LENGTH HUMAN TAS- PASE1: TOWARDS NOVEL ANTI-CANCER THERAPEUTICS.  Jose M. Garcia, Nirupa Nagaratnam , Rebecca Jernigan, Gihan Ketawala, Silvia Delker, Thomas Edwards, Derek Mendez, Chufeng Li, Nadia Zatsepin, Raimund Fromme, Liang Tong, Joel Schneider, James Hsieh, Andrew Flint, Petra 10:00 am ISOTOPICALLY EDITED VIBRATIONAL SPECTRA AND DYNAMICS FOR THREE-STRAND B-SHEET PEPTIDES. DFT SPECTRAL AND MD DYNAMICS SIMULATIONS.  Timothy A. Keiderling , Heng Chi, Dan McElheny, David Scheerer, Mohammad Shahid Islam, Karin Hauser Platform Cell Mechanics, Mechanosensing, and Motility 8:15 am - 10:15 am, Room 309/310 Co-Chairs Ritvik Vasan, University of California, San Diego Aurelia Honerkamp-Smith, Lehigh University 94-Plat 8:15 am MICROTUBULE FUNCTION IN THE MECHANOSENSITIVE REGULATION OF CELL MIGRATION.  Shailaja Seetharaman, Bertille Bance, Sandrine Etienne-Manneville 95-Plat 8:30 am CELL MIGRATION ON COMPLIANT SUBSTRATES REQUIRES ACTIN POLYM- ERIZATION BY THE ARP2/3 COMPLEX.  Devin B. Mair , Matthew Perrone, Jin Zhu, Ceylin Elmasli, Seth H. Weinberg, Rong Li 96-Plat 8:45 am NUMERICAL INVESTIGATION OF LEUKOCYTE ROLLING, ADHESION AND BOND FORMATION ON SURFACE COATED WITH VARYING P-SELECTIN DENSITY.  Grishma S. Prabhukhot , Rohan Banton, Charles D. Eggleton 97-Plat 9:00 am INFERRING CELL COLONY FORCES ACROSS TIME FROM TIGHT JUNCTION INTERSECTIONS IN HUMAN INDUCED PLURIPOTENT STEM CELLS.  Ritvik Vasan , C David Williams, Mary M. Maleckar, Padmini Rangamani 9:15 am Flash talks 98-Plat 9:30 am RELATIONSHIP BETWEEN CELL FORCE, SHAPE, AND MOTION IN COLLEC- TIVE CELL MIGRATION.  Aashrith Saraswathibhatla, Jacob Notbohm 99-Plat 9:45 am TRAVEL AWARDEE MECHANICS OF CELL SHEET FOLDING - EMBRYONIC INVERSION IN THE GREEN ALGAE VOLVOX.  Stephanie S.M.H. Hoehn , Pierre A. Haas, Aurelia R. Honerkamp-Smith, Raymond E. Goldstein 100-Plat 10:00 am NUCLEAR RUPTURE AT SITES OF HIGH CURVATURE COMPROMISES RETENTION OF DNA REPAIR FACTORS.  Irena L. Ivanovska , Yuntao Xia, Kuangzheng Zhu, Lucas Smith, Cory Alvey, Jerome Irianto, Charlotte Pfeifer, Jiazheng Ji, Dazhen Liu, Sangkyun Cho, Rachel Bennett, Andrea Liu, Roger A. Greenberg, Dennis E. Discher 9:30 am Fromme 93-Plat

80-Plat 8:30 am C-TYPE INACTIVATION IN K V

2.1 CHANNELS.  Carlos A. Villalba-Galea ,

Takeharu Kawano, Diomedes E. Logothetis 81-Plat 8:45 am

F R I D A Y

S U N D A Y

STRUCTURAL BASIS FOR ELECTROMECHANICAL COUPLING IN A HYPER- POLARIZATION-ACTIVATED ION CHANNEL. Michael D. Clark , Gustavo Contreras, Rong Shen, Eduardo Perozo 82-Plat 9:00 am TRAVEL AWARDEE MODULATION OF KV10.1 POTASSIUM CHANNEL FUNCTION BY INTRACEL- LULAR HEME.  Nirakar Sahoo , Ina Coburger, Kefan Yang, Sandip M Swain, Guido Gessner, Reinhard Kappl, Diana Imhof, Toshinori Hoshi, Roland Schoenherr, Stefan H. Heinemann 83-Plat 9:15 am STRUCTURAL BASIS FOR LIPID-DEPENDENT GATING OF A VOLTAGE-GAT- ED POTASSIUM CHANNEL.  Gaya P. Yadav , Mahesh Chandak, Liang Shi, Hui Zheng, Qiu-Xing Jiang 84-Plat 9:30 am MOLECULAR DETERMINANTS OF GATING POLARITY IN HYPERPOLARIZA- TION-ACTIVATED HCN CHANNELS.  John Cowgill , Vadim Klenchin, Claudia P. Alvarez Baron, Debanjan Tewari, Baron Chanda 85-Plat 9:45 am MOLECULAR SIMULATIONS OF ION PERMEATION, GATING AND SELEC- TIVITY IN K + CHANNELS. Wojciech Kopec , Bert L. de Groot 86-Plat 10:00 am VOLTAGE-SENSING RESIDUES IN THE VOLTAGE SENSOR OF THE BK CHAN- NEL. Willy R. Carrasquel-Ursulaez , Ignacio Segura, Yenisleidy Lorenzo, Dario Basaez, Ramon Latorre Platform Protein Structure and Conformation I 8:15 am - 10:15 am, Room 307/308 Co-Chairs Steven Whitten, Texas State University Vatsal Purohit, Purdue University 87-Plat 8:15 am CONFORMATIONAL BIAS IN UNFOLDED PROTEINS STUDIED BY SE- QUENCE REVERSAL.  Steven T. Whitten , Lance R. English 88-Plat 8:30 am TRAVEL AWARDEE TIME-RESOLVED CRYSTALLOGRAPHY MEASUREMENTS ELUCIDATING THE MECHANISM OF BACTERIAL HMG-COA REDUCTASE.  Vatsal Purohit , Calvin Steussy, Tim Schmidt, Chandra J. Critchelow, Tony Rosales, Cynthia Stauffacher, Paul Helquist, Olaf Weist 89-Plat 8:45 am UNDERSTANDING THE MOLECULAR UNDERPINNINGS OF COLLAGEN- PROTEIN INTERACTIONS IN HEALTHY AND PATHOLOGICAL STATES.  Cody L. Hoop , Jie Zhu, Allysa Kemraj, David A. Case, Jean Baum 90-Plat 9:00 am TRAVEL AWARDEE STRUCTURAL INSIGHTS INTO MDN1, AN ~540 KDA AAA PROTEIN REQUIRED FOR RIBOSOME BIOGENESIS.  Zhen Chen , Hiroshi Suzuki, Yuki Kobayashi, Ashley C. Wang, Frank DiMaio, Shigehiro A. Kawashima, Thomas Walz, Tarun M. Kapoor 9:15 am Flash talks

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