Biophysical Society 63rd Annual Meeting | Program Guide

Platform Membrane Active Peptides and Toxins 4:00 pm - 6:00 pm, Room 316/317

208-Plat 5:30 pm MOLECULAR DYNAMICS SIMULATION AND PHOTO-CROSSLINKING RE- VEAL A SPECIFIC CHOLESTEROL BINDING SITE FOR THE METABOTROPIC GLUTAMATE RECEPTOR 2. Markus Kurth , Rainer Beck, Camilo A. Aponte- Santamaria, Britta Bruegger 209-Plat 5:45 pm DIRECT LIPID BINDING IN A PENTAMERIC LIGAND-GATED ION CHANNEL ASSESSED BY NATIVE MASS SPECTROMETRY. Wayland WL Cheng Platform Intracellular Calcium Signaling, Sparks and Waves 4:00 pm - 6:00 pm, Room 314/315 Co-Chairs TRAVEL AWARDEE MODELLING THE ATP BINDING SITE OF RYR2 TO RATIONALISE LIGAND- INDUCED GATING BEHAVIOUR.  Chris Lindsay , Mano Sitsapesan, Wei Mun Chan, Elisa Venturi, WilliamWelch, Maria Musgaard, Rebecca M. Sitsapesan 211-Plat 4:15 pm A CRYO-EM BASED STUDY OF A MUTANT CARDIAC RYANODINE RECEP- TOR (RYR2).  Kavita A. Iyer , Ashok R. Nayak, Takashi Murayama, Nagomi Kurebayashi, Montserrat Samso 212-Plat 4:30 pm DETECTING RYR CLUSTERS WITH CACLEAN: VALIDATION AND INFLUENCE OF SPATIAL HETEROGENEITY.  David Ladd , Agne Tilunaite, H. Llewelyn Roderick, Christian Soeller, Edmund Crampin, Vijay Rajagopal 213-Plat 4:45 pm FRET-BASED TRILATERATION RESOLVES DISTINCT STRUCTURAL STATES AND TRANSITIONS OF CALMODULIN BOUND TO RYR.  Bengt Svensson , Robyn T. Rebbeck, Jingyan Zhang, Donald M. Bers, David D. Thomas, Razvan L. Cornea 214-Plat 5:00 pm 2D+T IMAGING OF CALCIUM SIGNALING MICRODOMAINS IN CARDIAC MYOCYTES. Mouna Abdesselem , Guillaume Gilbert, H Llewellyn Roder- ick, Karin R. Sipido 215-Plat 5:15 pm TRAVEL AWARDEE CALCIUM SENSING AND CONFORMATIONAL REARRANGEMENTS IN STIM1, THE ER CALCIUM SENSOR.  Aparna Gudlur , Ana E. Zeraik, Nupura Hirve, V Rajanikanth, Andrey A. Bobkov, Elizabeth A. Komives, Patrick G. Hogan 216-Plat 5:30 pm ABNORMAL CALCIUM LEAK FROM CARDIAC SARCOPLASMIC RETICU- LUM: NEW INSIGHTS OFFERED BY STATISTICAL PHYSICS.  Anna Maltsev , Michael D. Stern, Victor A. Maltsev 217-Plat 5:45 pm FILOPODIA DYNAMICS ARE AFFECTED BY CATION FLUX THROUGH TRP CHANNELS.  Carol A. Heckman , Marilyn L. Cayer, Omolade M. Ademu- wiya Carol Heckman, Bowling Green State University David Ladd, University of Melbourne, Australia 210-Plat 4:00 pm

S U N D A Y

Co-Chairs Myriam Cotten, College of William and Mary Georg Pabst, University of Graz, Austria 218-Plat 4:00 pm

SYNERGISM OF MAGAININS IS NOT COUPLED TO THE FORMATION OF A WELL-DEFINED PEPTIDE PORE. Michael Pachler, Ivo Kabelka, Regina Leber, Ilse Letofsky-Papst, Karl Lohner, Robert Vacha, Georg Pabst 219-Plat 4:15 pm COMBINING DESIGN STRATEGIES IN ENGINEERING MORE ACTIVE HYBRID ANTIMICROBIAL PEPTIDES.  Anne K. Buck , Louise E. O. Darling, Donald E. Elmore 220-Plat 4:30 pm HIGH-RESOLUTION STRUCTURES OF TWO METALLATED HOST DEFENSE PEPTIDES THAT FEATURE COPPER-DEPENDENT BACTERICIDAL AND CHEMOTACTIC EFFECTS: IMPORTANCE OF HISTIDINE FOR ANTI-INFECTIVE ACTION. Myriam Cotten , Alexander Greenwood, Steven Paredes, Yimin Miao, Yawei Xiong, Ella Mihailescu 221-Plat 4:45 pm COMPARISON OF THE EFFECTS OF DAPTOMYCIN ON BACTERIAL AND MODEL MEMBRANES. Ming-Tao Lee , Pei-Yin Yang, Nicholas E. Charron, Meng-Hsuan Hsieh, Yu-Yung Chang, Wei-Chin Hung, Huey W. Huang 222-Plat 5:00 pm LIFE AND DEATH IN A BACTERIAL BIOFILM UNDER ANTIBIOTIC ATTACK CHARACTERIZED BY FLUORESCENCE AND ATOMIC FORCE MICROSCOPY.  Catherine B. Volle , Kanesha Overton, Helen Greer, Megan A. Ferguson, Eileen M. Spain, Megan E. Nunez 223-Plat 5:15 pm INTERACTION OF ANTIMICROBIAL PEPTIDE LL-37 WITH LIPOPOLYSAC- CHARIDES. Michael Martynowycz, amy Rice, Konstantin Andreev, Thaty- ane M. Nobre Pavinatto, Jeff Wereszczynski, David Gidalevitz 224-Plat 5:30 pm TRAVEL AWARDEE SYNCHROTRON X-RAY SCATTERING STUDIES TO DETERMINE STRUCTURE OF amYLOID BETA INTERACTIONS WITH LIPID MEMBRANES.  Crystal M. Vander Zanden , Jaroslaw P. Majewski, Erik B. Watkins, Eva Y. Chi 225-Plat 5:45 pm CONFORMATIONAL DISORDER IS REQUIRED FOR TOXIN SECRETION, FOLDING AND CELL INTOXICATION.  Darragh Patrick O’Brien, Dominique Durand, Sara Cannella, Alexis Voegele, Patrice Vachette, Sébastien Brier, Daniel Ladant, Alexandre Chenal PI to PI A Wine & Cheese Mixer 5:00 pm - 7:00 pm, Room 324/325/326 You finally have a job working in biophysics, in industry or academia, with some funding and a lab, but you’ve realized that the career challenges continue. Come relax and network with your contemporaries and senior biophysicists over a beer or glass of wine. This event is a great chance to compare notes with colleagues and discuss one-on-one your unique solutions to issues that arise in the time between getting your job and getting your next promotion, including management of lab staff, getting your work published, and renewing your funding. Refreshments will be provided, with cash bar.

24