Biophysical Society 63rd Annual Meeting | Program Guide

467-Pos Board B242 GTP CONCENTRATION BURSTS LOCALLY AT ENDOCYTIC SITES FOR DYNAMIN-DEPENDENT MEMBRANE FISSON. Aisha Azhar , Yuuta Imoto, Shigeki Watanabe 468-Pos Board B243 DYNAMIN-1 DRIVES FISSION OF VESICLES WITHIN 100 MS DURING SYN- APTIC VESICLE ENDOCYTOSIS. Yuuta Imoto , Sumana Raychaudhuri, Aisha Azhar, Shigeki Watanabe 469-Pos Board B244 TRAVEL AWARDEE MECHANOCHEMICAL FEEDBACK CONTROL OF DYNAMIN INDEPEN- DENT ENDOCYTOSIS MODULATES MEMBRANE TENSION IN ADHER- ENT CELLS.  Joseph Jose Thottacherry , Anita Joanna Kosmalska, Susav Pradhan, Parvinder Pal Singh, Xavier Trepat, Ram Vishwakarma, Pramod Pullarkat, Pere Roca-Cusachs, Satyajit Mayor 470-Pos Board B245 THE EFFECT OF ACUTE ATP DEPLETION ON SYNAPTIC VESICLE ENDOCY- TOSIS AT THE ULTRASTRUCTURAL LEVEL. Quan Gan , Shigeki Watanabe 471-Pos Board B246 QUANTIFYING CEACAM TARGETED LIPOSOME DELIVERY USING IMAG- ING FLOW CYTOMETRY.  Jason P. Kuhn , Asya Smirnov, Alison Criss, Linda Columbus 472-Pos Board B247 3D TRAFFICKING OF EPIDERMAL GROWTH FACTOR RECEPTOR IN LIVE CELLS. Marco A. Alfonzo Mendez , Harshad Viswasrao, Hari Shroff, Justin W. Taraska 473-Pos Board B248 PHOSPHATIDYLSERINE (PS) EXTERNALIZATION FACILITATES MEMBRANE VESICULATION THROUGH DECREASING MEMBRANE STIFFNESS.  Hongyin Wang , Joseph H. Lorent, Lakshmi Ganesan, Blanca B. Diaz- Rohrer, Kandice R. Levental, Eric Malmberg, Ilya Levental Excitation-Contraction Coupling I (Boards B249 - B264) 474-Pos Board B249 CHRONIC EFFECTS OF ALDOSTERONE ON CARDIAC EC COUPLING AND OXIDANT STRESS. María Guadalupe Montiel-Jaen , Adrian Monsalvo- Villegas, Guillermo Avila 475-Pos Board B250 UNDERLYING PHYSIOLOGICAL CONDITION ACT AS A CRITICAL FACTOR IN PHENOTYPIC REALIZATIONS OF EXCITATION COUPLING (EC) ABNORMALI- TIES IN TARGETED CANCER THERAPEUTIC TREATED HIPSC CARDIOMYO- CYTES.  Jaehee Shim 476-Pos Board B251 IMPERACALCIN’S ANTIARRHYTHMIC EFFECTS ARE PRESERVED AT 37 0 C IN WHOLE HEARTS FROM A CPVT MOUSE MODEL. Rachael N. Thorson, Jordan Price, Yuriana Aguilar, Carmen R. Valdivia, Héctor Valdivia, Rafael Mejía-Alvarez 477-Pos Board B252 IMPAIRED Β-ADRENERGIC RESPONSIVENESS IN HFPEF RATS.  Peter J. Kilfoil , Daniel Soetkamp, Rui Zhang, Jae Cho, Stephan Aynaszyan, Eugenio Cingolani, Eduardo Marbán, Joshua I. Goldhaber 478-Pos Board B253 QUANTITATIVE IN SILICO ANALYSIS OF THE ARRHYTHMOGENIC CAMKII- SODIUM-CALCIUM-CAMKII FEEDBACK IN THE FAILING RABBIT VENTRICU- LAR MYOCYTE. Caroline Liu, Bence Hegyi, Haibo Ni, Donald M. Bers, Eleonora Grandi, Stefano Morotti

479-Pos Board B254 LOSS OF DYSTROPHIN ALTERS CALCIUM-HANDLING MATURATION IN RESPONSE TO MICROENVIRONMENT IN HIPSC-CARDIOMYOCYTES FROM DUCHENNE MUSCULAR DYSTROPHY PATIENTS.  J. Manuel Pioner , Raffaele Coppini, Lorenzo Santini, Chiara Palandri, Flavia Lupi, Marianna Langione, Patrizia Benzoni, Sara Landi, Andrea Barbuti, Chiara Tesi, David L. Mack, Michael Regnier, Camilla Parmeggiani, Corrado Poggesi, Cecilia Ferrantini 480-Pos Board B255 DUAL CALCIUM AND VOLTAGE MAPPING REVEALS DIFFERENCES IN MATURITY OF EXCITATION-CONTRACTION COUPLING IN YOUNG RAT HEARTS. Luke Swift, Rafael Jaimes , Nikki G. Posnack 481-Pos Board B256 IN VIVO GENE DELIVERY OF R-CEPIA1ER: A NEW APPROACH TO STUDY [CA] SR HANDLING IN CARDIOMYOCYTES. Elisa Bovo , Quan Cao, Daniel Kahn, Roman Nikolaienko, Jody L. Martin, Ivana Y. Kuo, Aleksey V. Zima 482-Pos Board B257 AN AUTOSOMAL DOMINANT MUTATION IN CALSEQUESTRIN 2 CAUSES CPVT WITHOUT CHANGING PROTEIN LEVELS. MatthewWleklinski , Shan Parikh, Bjorn C. Knollmann 483-Pos Board B258 BRIDGING HTS ION CHANNEL AND MYOCYTE DATA. George O. Okeyo , Sonja Stoelzle-Feix, Timothy Strassmaier, Krisztina Juhasz, Nadine Becker, Ulrich Thomas, Leo Doerr, Markus Rapedius, Nina Brinkwirth, Claudia Haarmann, Tom Goetze, Matthias Beckler, Michael George, Andrea Brüggemann, Niels Fertig 484-Pos Board B259 THE ABSENCE OF ACTIVE CREATINE KINASE SYSTEM INFLUENCES CAR- DIAC CALCIUM HANDLING. Martin Laasmaa , Jelena Branovets, Niina Karro, Rikke Birkedal, Marko Vendelin 485-Pos Board B260 FUNCTIONAL IMPACT OF CELL CULTURE ON EXCITATION-CONTRACTION COUPLING IN CANINE MYOCYTES. Alida Cooke, Zachary Williams, Samuel Olczyk, Robert J. Goodrow, Jonathan A. Cordeiro, Jacqueline A. Treat, Gary L. Aistrup , Jonathan M. Cordeiro 486-Pos Board B261 DOUBLE REGULATION OF CARDIAC EXCITATION-CONTRACTION COU- PLING AND OXIDANT STRESS BY PIRFENIDONE.  Adrian Monsalvo-Villegas , Guillermo Avila 487-Pos Board B262 MECHANICAL LOAD EFFECTS ON CARDIAC ACTION POTENTIAL AND AR- RHYTHMOGENIC CA 2+ ACTIVITIESREVEALED BY A NOVEL PATCH-CLAMP- IN-GEL TECHNOLOGY. Zhong Jian , Bence Hegyi, Mark Jaradeh, Zana A. Coulibaly, Yi-je Chen, Kit S. Lam, Leighton T. Izu, Ye Chen-Izu 488-Pos Board B263 THE EFFECTS OF MECHANICAL LOAD ON TRANSMURAL DIFFERENCES IN MECHANO-ELECTRIC FEEDBACK IN SINGLE CARDIOMYOCYTES. Anastasia Khokhlova, Gentaro Iribe, Pavel Konovalov, Leonid Katsnelson, Olga Solovyova 489-Pos Board B264 FUNCTIONAL CONNECTOME OF THE MECHANICALLY LOADED CARDIO- MYOCYTE II: COORDINATED CHANGES OF SUBSYSTEMS. Zana Coulibaly, Zhong Jian, Rafael Shimkunas, Ye Chen-Izu, Leighton T. Izu

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