Biophysical Society 63rd Annual Meeting | Program Guide

Cardiac Smooth and Skeletal Muscle Electrophysiology I (Boards B265 - B280) 490-Pos Board B265 PHARMACOLOGICAL AND ISCHEMIC PRECONDITIONING UP-REGULATE THE EXPRESSION OF SOCS IN ADULT CARDIAC MYOCYTES: ITS PHYSI- OLOGICAL SIGNIFICANCE. Raúl Sampieri , Joice Thomas, Maria C. Garcia, Elba D Carrillo, Eridani Fuentes, Wilibaldo Orea, Jorge A. Sanchez 491-Pos Board B266 TRAVEL AWARDEE DIABETIC HYPERGLYCEMIA REGULATES POTASSIUM CHANNELS AND ARRHYTHMIAS IN THE HEART VIA AUTONOMOUS CAMKII ACTIVATION BY O -LINKED GLYCOSYLATION. Bence Hegyi , Johanna M. Borst, Austen J. Lucena, Logan R.J. Bailey, Julie Bossuyt, Donald M. Bers 492-Pos Board B267 AGE DEPENDENT REGULATION OF CARDIAC SODIUM CHANNEL GAIN OF FUNCTION. Madison B. Nowak , David Ryan King, Steven Poelzing, Seth H. Weinberg 493-Pos Board B268 INHIBITON OF PROTEIN KINASE G PRESERVES PROLONGED VENTRICULAR ACTION POTENTIALS VIA IMPROVEMENT OF SLOW-ACTIVATED VOLT- AGE-DEPENDENT K + -CHANNEL CURRENTS IN AGED RAT CARDIOMYO- CYTES. Belma Turan , Yusuf Olgar, Erkan Tuncay 494-Pos Board B269 THE EFFECTS OF PINACIDIL, AN ATP SENSITIVE K + CHANNEL OPENER ON CARDIAC NA + /CA 2+ EXCHANGER FUNCTION IN GUINEA PIG CARDIO- MYOCYTES. Keisuke Iguchi , Masao Saotome, Kanna Yamashita, Takenori Ikoma, Prottoy Hasan, Yuichiro Maekawa, Yasuhide Watanabe 495-Pos Board B270 EXTRACELLULAR PH BUT NOT OSMOTIC PRESSURE MODULATES CL - CUR- RENT IN FRESHLY-ISOLATED GUINEA PIG DETRUSOR SMOOTH MUSCLE CELLS. Viktor Yarotskyy , Georgi V. Petkov 496-Pos Board B271 ENGINEERING AN OPTOGENETIC SYSTEM FOR POINT-PACING CARDIOMY- OCYTES IN CULTURE. Geran Kostecki, Shivani Pandey, Renjun Zhu, Emilia Entcheva, Leslie Tung 497-Pos Board B272 INTRODUCING SIMULATED IK1 INTO HUMAN IPSC-CARDIOMYOCYTES US- ING DYNAMIC CLAMP ON AN AUTOMATED PATCH CLAMP SYSTEM.  Gang Lu , András Horváth, Nadine Becker, Alan Fabbr, Christian Grad, Michael George, Niels Fertig, Teun P. de Boer 498-Pos Board B273 ESTABLISHING PATHOGENICITY OF NOVEL LQTS8 VARIANT VIA GENOMIC EDITING OF HUMAN IPSC. Dmytro O. Kryshtal , Nikhil V. Chavali, Shan S. Parikh, Lili Wang, AndrewM. Glazer, Moore B. Shoemaker, Bjorn C. Knollmann 499-Pos Board B274 EFFECT OF A SMALL MOLECULE ACTIVATOR OF POTASSIUM CURRENTS ON REPOLARIZATION RESERVE IN HIPSC-CARDIOMYOCYTES. Jacqueline A. Treat, Robert J. Goodrow, Gary L. Aistrup, Corina T. Bot, Jonathan M. Cordeiro 500-Pos Board B275 HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES AS EARLY-SCREENING PLATFORM OF ANTI-ARRHYTHMIC EFFECTS BY PUFAS. Alicia de la Cruz , Rene Barro-Soria, Sara I. Liin, H. Peter Larsson

501-Pos Board B276 OPTOGENETIC CONTROL OF RE-ENTRANT WAVES DEMONSTRATED IN HUMAN INDUCED STEM CELL DERIVED CARDIOMYOCYTES (HIPSC- CMS). B Adrienne Caldwell , Miguel Romero Seplvuda, Gil Bub, Alvin Shrier 502-Pos Board B277 EFFECT OF REAL-TIME LEAK CURRENT CORRECTION ON ACTION POTEN- TIALS RECORDED FROM INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIAC MYOCYTES. Brian Panama , Mark Nowak, Brandon Franks, Leigh Korbel, Glenna Bett, Randall Rasmusson 503-Pos Board B278 THE EFFECTS OF NOISE IN BIOLOGICAL EXCITABLE MEDIA.  J. Miguel Romero Sepúlveda , B. Adrienne Caldwell, Alvin Shrier, Gil Bub 504-Pos Board B279 LONGITUDINAL CARDIOTOXIC EFFECT OF DOXORUBICIN IN A MULTICEL- LULAR CARDIAC MODEL. Viviana Zlochiver , Stacie Edwards, Rosy Joshi- Mukherjee 505-Pos Board B280 A COMPUTATIONAL APPROACH TO PREDICT MECHANISMS OF PHENO- TYPIC VARIABILITY IN INDUCED PLURIPOTENT STEM CELL-DERIVED CAR- DIOMYOCYTES. Divya C. Kernik , Stefano Morotti, Garg Priyanka, Joseph C. Wu, Jose Jalife, Eleonora Grandi, Colleen E. Clancy Voltage-gated K Channels I (Boards B281 - B298) 506-Pos Board B281 MOLECULAR MECHANISMS OF FILTER-LEVEL GATING AND LOSS OF SE- LECTIVITY IN HERG1 N629D MUTANT FROMMICROSECONDS MD SIMU- LATIONS. Williams E. Miranda , Henry J. Duff, Jiqing Guo, Igor V. Vorobyov, Kevin R. DeMarco, Colleen E. Clancy, Sergei Yu. Noskov 507-Pos Board B282 DYNAMICS OF PORE DOMAIN AFFECTED BY SINGLE MUTATIONS IN S4 SEGMENT OF SHAKER POTASSIUM CHANNEL.  Carlos Alberto Z. Bassetto Jr , Joao Luis Carvalho-de-Souza, Francisco Board B283 SCREENING OF NEGATIVE CHARGES BY CA 2+ IN THE TURRET REGION CONTROLS KV7.1 INACTIVATION GATING AND IS REGULATED BY PIP2 AND CALMODULIN. Bernard Attali , William S. Tobelaim, Maya Lipinsky, Asher S. Peretz, Daniel Yakubovich, Yoav Paas 509-Pos Board B284 QUANTUM CALCULATIONS ON PROTON TRANSPORT IN THE KV1 CHAN- NEL VOLTAGE SENSING DOMAIN, WITH COMPARISON TO ANALOGS IN BACTERIORHODOPSIN, CYTOCHROME C, AND THE H V 1 PROTON CHAN- NEL. Alisher M. Kariev, Michael E. Green 510-Pos Board B285 MOBILITY OF S3-S4 LINKER MODULATES ACTIVATION PROCESS IN SHAK- ER POTASSIUM CHANNELS.  Joao L. Carvalho-de-Souza , Carlos Bassetto Jr, Elizabeth EL Lee, Francisco Bezanilla 511-Pos Board B286 VOLTAGE DEPENDENT GATING OF BK CHANNELS - WHERE IS THE SPRING? Karl L. Magleby , Yanyan Geng 512-Pos Board B287 INFLUENCE OF DIMERIC INTERACTIONS ON VOLTAGE SENSING PHOSPHA- TASE ACTIVITY. Vamseedhar Rayaprolu , Perrine Royal, Guillaume Sandoz, Susy C. Kohout Bezanilla 508-Pos

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