Biophysical Society 63rd Annual Meeting | Program Guide

513-Pos Board B288 NATURE UTILIZATION OF THE SLOW INACTIVATION MECHANISM IN VOLTAGE GATED K + CHANNELS.  Izhar Karbat , Hagit Gueta, Tibor Szanto, Shelly Hamer-Rogotner, Orly Dym, Felix Frolow, Dalia Gordon, Gyorgy Panyi, Michael Gurevitz, Eitan Reuveny 514-Pos Board B289 CALCIUM REGULATION OF KV4-KCHIP ION CHANNEL COMPLEXES.  Jonathan G. Murphy , Dax A. Hoffman 515-Pos Board B290 IN SILICO DETERMINATION OF OPEN CONDUCTING AND INACTIVATED ATOMISTIC K V 11.1 CHANNEL MODELS.  John R. D. Dawson , Kevin R. DeMarco, Borislava Bekker, Sergei Y. Noskov, Colleen E. Clancy, Igor V. Vorobyov 516-Pos Board B291 THE ROLE OF HCN DOMAIN IN THE FUNCTION OF HCN CHANNELS.  Zejun Wang , Sebastien Hayoz, Tinatin I. Brelidze 517-Pos Board B292 TRAPPING THE 2,4-K + -ION BOUND CONFIGURATION OF KCSA’S SELECTIV- ITY FILTER. Cholpon Tilegenova, D. Marien Cortes, Nermina Jahovic, Emily Hardy, Parameswaran Hariharan, Lan Guan, Luis G. Cuello 518-Pos Board B293 QUANTUM CALCULATIONS ON THE K + ION IN THE K V 1.2 CHANNEL PORE: HYDRATION AND COSOLVATION. Alisher M. Kariev , Michael E. Green 519-Pos Board B294 NOBILETIN INHIBITION OF BK CHANNELS. Liang Sun , Lorie Ann Gonzalez, Frank T. Horrigan 520-Pos Board B295 LOSS OF HAX-1 MAY CONTRIBUTE TO THE NEURODEGENERATION CAUSED BY A KV3.3 MUTATION. Yalan Zhang , Luis Varela, Klara Szigeti- Buck, Tamas L. Horvath, Leonard K. Kaczmarek 521-Pos Board B296 MODULATION OF KV7.1/KCNE1 CHANNEL ACTIVITY BY NAVΒ1.  Spencer Mason Webber , Carlos Villalba-Galea 522-Pos Board B297 STRUCTURAL MODELING OF THE HERG CHANNEL IN AN INACTIVATED STATE AND ITS DRUG INTERACTIONS.  Jan Maly , Aiyana M. Emigh, Kevin R. DeMarco, Jon T. Sack, Igor Vorobyov, Colleen E. Clancy, Vladimir Yarov- TRAVEL AWARDEE DIFFERENTIAL REGULATION OF BK CHANNELS BY FRAGILE X MENTAL RETARDATION PROTEIN. Aravind Kshatri , Alejandro Cerrada, Roger Gimeno, Teresa Giraldez Ligand-gated Channels I (Boards B299 - B325) 524-Pos Board B299 FÖRSTER RESONANCE ENERGY TRANSFER (FRET) ANALYSIS OF THE C- TERMINAL DOMAIN OF FP-TAGGED HOMOMERIC AND HETEROMERIC AMPARS UPON PHOSPHORYLATION. Linda G. Zachariassen , Anne-Sophie Hafner, Daniel Choquet, Anders S. Kristensen 525-Pos Board B300 THE STRUCTURAL ARRANGEMENT AND DYNAMICS OF HOMOMERIC KAINATE RECEPTORS DETERMINED BY SMFRET. Douglas B. Litwin , Elisa Carrillo, Sana Shaikh, Vladimir Berka, Vasanthi Jayaraman 526-Pos Board B301 SINGLE-MOLECULE FRET INVESTIGATIONS OF NEGATIVE COOPERATIVITY IN THE NMDA RECEPTOR. Ryan J. Durham , Nabina Paudyal, Elisa Carrillo, Vladimir Berka, Vasanthi Jayaraman Yarovoy 523-Pos Board B298

527-Pos TRAVEL AWARDEE STUDY OF A HETEROMERIC KAINATE RECEPTOR GLUK2/K5 BY PROBING SINGLE-MOLECULE FRET. Nabina Paudyal , Douglas B. Litwin, Vladmir Berka, Elisa Carrillo Flores, Vasanthi Jayaraman 528-Pos Board B303 COMPUTING FREE ENERGY OF THE MAGNESIUM BLOCK IN N-METHYL- D-ASPARTATE RECEPTORS. Christopher Kottke , Samaneh Mesbahi-Vasey, Maria G. Kurnikova 529-Pos Board B304 MECHANISM OF AMPA RECEPTOR MODULATION BY GAMMA-8. Elisa Carrillo Flores , Sana A. Shaikh, Vasanthi Jayaraman 530-Pos Board B305 MAPPING STRUCTURAL ELEMENTS TO NMDA RECEPTOR ACTIVATION STEPS. Gary J. Iacobucci , Han Wen, Matthew Helou, Wenjun Zheng, Gabriela K. Popescu 531-Pos Board B306 GATING OF SINGLE AMPA RECEPTORS CROSS-LINKED AT THE LIGAND BINDING DOMAIN LAYER. Sebastian Opfermann , Jelena Baranovic, Andrew J.R. Plested 532-Pos Board B307 COMPUTATIONAL CHARACTERIZATION OF THE BINDING OF NON-COM- PETITIVE INHIBITORS TO AMPA RECEPTORS. Chamali Narangoda , Serzhan Sakipov, Maria G. Kurnikova 533-Pos Board B308 LIFE IN THE FAST LANE: BINDING TO GLUTAMATE RECEPTORS. Alvin Yu, Hector P. Salazar, Andrew J. Plested, Albert Y. Lau 534-Pos Board B309 AGONIST AND INHIBITOR BINDING EFFECTS ON AMPA RECEPTOR INTERNAL STRUCTURE AND DYNAMICS. Serzhan Sakipov , Chamali m. Na- rangoda, Samaneh Mesbahi, Jose C. Flores-Canales, Christopher Kottke, Maria G. Kurnikova 535-Pos Board B310 SUBUNIT-DEPENDENT MODULATION OF AMPAR GATING BY AUXILIARY PROTEINS.  Irene Riva , Jelena Baranovic, Anna L. Carbone, Andrew J. Plested 536-Pos Board B311 SIGNAL PEPTIDE REPRESSES KAINATE RECEPTOR GLUK1 SURFACE AND SYNAPTIC TRAFFICKING THROUGH DIRECT INTERACTION WITH AMINO- TERMINAL DOMAIN. Guifang Duan 537-Pos Board B312 DEVELOPMENT OF A HIGH-THROUGHPUT CA 2+ FLUX SCREENING ASSAY TO MONITOR CYCLIC NUCLEOTIDE-GATED CHANNEL ACTIVITY AND EVALUATE ACHROMATOPSIA DISEASE MUTANT CHANNEL FUNCTION.  Jacqueline Tanaka , Cristy Almonte, Elizabeth McDuffie, Laura Jones, Den- nis Colussi, Marlene Jacobson 538-Pos Board B313 ALLOSTERIC GATING REARRANGEMENTS OF A PROKARYOTIC CYCLIC NUCLEOTIDE-GATED ION CHANNEL REVEALED WITH PULSED DIPOLAR SPECTROSCOPY. Eric G.B. Evans , Jacob L.W. Morgan, Stefan Stoll, William N. Zagotta 539-Pos Board B314 FUNCTIONAL CHARACTERIZATION OF GATING IN A BACTERIAL CYCLIC NUCLEOTIDE-GATED CHANNEL.  Jacob Morgan , Eric Evans, William Zagotta 540-Pos Board B315 OPPOSING SUBUNITS INTERACT TO STABILIZE THE CLOSED STATE IN HCN2 CHANNELS. Mahesh Kondapuram , Sezin Yüksel, Tina Schwabe, Benedikt Frieg, Holger Gohlke, Ralf Schmauder, Klaus Benndorf, Jana Kusch Board B302

S U N D A Y

38