Biophysical Society 63rd Annual Meeting | Program Guide

554-Pos

541-Pos Board B316 UNCOUPLING THE CAMP BINDING DOMAIN FROM THE CHANNEL GATE IN HCN2 CHANNELS. Sezin Yüksel , Mahesh Kondapuram, Tina Schwabe, Michele Bonus, Holger Gohlke, Ralf Schmauder, Jana Kusch, Klaus Ben- ndorf 542-Pos Board B317 NUCLEOTIDE MODULATION OF K ATP CHANNELS DISENTANGLED WITH FRET. Michael C. Puljung , Samuel Usher, Natascia Vedovato, Frances Board B318 SINGLE MOLECULE FRET REVEALS LIPID INDUCED CONFORMATIONAL CHANGES IN CYTOPLASMIC DOMAIN OF KIR2.1.  Joshua B. Brettmann , Sun Joo Lee, Shizhen Wang, Colin G. Nichols 544-Pos Board B319 MULTIPLE NUCLEOTIDE-DEPENDENT CONFORMATIONS OF A MYCOBAC- TERIAL RCK DOMAIN. Alexandre G. Vouga, Katia K. Matychak, Michael E. Rockman, Lisandra Flores, Sebastian Brauchi, Brad S. Rothberg 545-Pos Board B320 RCK DOMAINS CAN ASSEMBLE AS HETERO-OCTAMERS AND CONTROL DIFFERENT LIGAND-GATED CHANNELS. Rita Rocha , Celso Teixeira Duarte, Joao M. P. Jorge, Joao H. Morais Cabral 546-Pos Board B321 CHARACTERIZING P2X 2 MUTANTS ASSOCIATED WITH PROGRESSIVE SENSORINEURAL HEARING LOSS (DFNA41). Benjamin I. George , Mufeng Li, Kenton J. Swartz 547-Pos Board B322 ELUCIDATING THE FUNCTION AND CELL-SPECIFIC INTERACTIONS OF P2X7 RECEPTOR VARIANTS LINKED TO MENTAL DISORDERS. Mette Homann Poulsen , Jamie Fang, Stephan A. Pless 548-Pos Board B323 TRAVEL AWARDEE STOMATIN DEPENDENT REGULATION OF THE ACID SENSING ION CHAN- NELS. Robert C. Klipp , John Bankston 549-Pos Board B324 INDIRECT DETERMINANTS OF ION SELECTIVITY IN ACID-SENSING ION CHANNELS AND EPITHELIAL SODIUM CHANNELS. Zeshan P. Sheikh , Timothy Lynagh, Anders S. Kristensen, Stephan A. Pless 550-Pos Board B325 MOLECULAR BASIS FOR ION SELECTIVITY IN HETEROMERIC ACID-SENS- ING ION CHANNELS. Zeshan P. Sheikh , Timothy Lynagh, Emelie Flood, Celine Boiteux, Toby W. Allen, Stephan A. Pless Voltage-gated Ca Channels (Boards B326 - B338) 551-Pos Board B326 TRAVEL AWARDEE A MUTATION LINKED TO MALIGNANT HYPERTHERMIA IN THE SKELETAL CA V 1.1 CHANNEL STABILIZES THE RESTING STATE OF VOLTAGE SENSOR I AND IMPAIRS CHANNEL ACTIVATION. Nicoletta Savalli , Fenfen Wu, Mar- bella Quinonez, Stephen C. Cannon, Riccardo Olcese 552-Pos Board B327 DESIGN AND APPLICATIONS OF THE NEW CALCIUM SENSOR GCAMP- X. Yaxiong Yang, Yuanyuan He, Xiaodong Liu 553-Pos Board B328 TRAVEL AWARDEE PROBING L-TYPE CHANNEL CALCIUM-DEPENDENT INACTIVATION – A BILOBAL MODEL OF CALMODULATION. Worawan B. Limpitikul , Joseph L. Greenstein, David T. Yue, Ivy E. Dick, Raimond L. Winslow Ashcroft 543-Pos

Board B329

CARDIAC O 2 SENSOR: A TRIO OF HEMEOXYGENASE, CAMKII & CARBOXYL TAIL OF CA 2+ CHANNEL.  Jose Carlos Fernandez Morales , Naohiro Yamagu- chi, Martin Morad 555-Pos Board B330 TREATMENT OF CA V 1.2 CHANNELOPATHIES MAY BE COMPLICATED BY ALTERED CHANNEL INACTIVATION. Moradeke A. Bamgboye , Maria Trafi- cante, David T. Yue, Ivy E. Dick 556-Pos Board B331 POSSIBLE MECHANISM OF CALCIUM-DEPENDENT BLOCK OF L-TYPE CAL- CIUM CHANNEL BY GLACONTRYPHAN-M. Vyacheslav S. Korkosh, Denis B. Tikhonov, Boris S. Zhorov 557-Pos Board B332 BETA AMYLOID PEPTIDE (1-42) MEDIATED DYSREGULATION OF L-TYPED VOLTAGE GATED CALCIUM CHANNEL 1.2 THROUGH THE BETA-2 ADREN- ERGIC RECEPTOR. Liangying Li , Jennifer Price, Boram Lee, Johannes Hell 558-Pos Board B333 STRUCTURE MODELLING OF CA V 1.1 REVEALS FUNCTIONAL TRANS- DOMAIN INTERACTIONS INVOLVED IN VOLTAGE SENSING. Monica L. Fernández-Quintero , Yousra El Ghaleb, Petronel Tuluc, Campiglio Campi- glio, Klaus R. Liedl, Bernhard E. Flucher 559-Pos Board B334 SKELETAL Γ1 SUBUNIT MODULATION OF HUMAN CA V 1.1 AND CA V 1.2 CHANNELS. Marina Angelini , Nicoletta Savalli, Taleh Yusifov, Riccardo Olcese 560-Pos Board B335 A LOCAL-CONTROL MODEL OF THE GUINEA PIG VENTRICULAR MYOCYTE ALLOWS UNDERSTANDING OF FORCE-INTERVAL RELATIONS AT THE CAL- CIUM SPARK LEVEL. Roshan Paudel 561-Pos Board B336 HOW DOES THE Α 2 Δ-1 SUBUNIT MODULATE SKELETAL CA V 1.1 CHAN- NELS? Federica Steccanella , Nicoletta Savalli, Taleh Yusifov, Giovanni Battista Luciani, Alan Neely, Riccardo Olcese 562-Pos Board B337 AUXILIARY BETA SUBUNITS ARE NOT OBLIGATORY FOR CA V 1.3 FUNC- TION. Sharen Rivas , Johanna Diaz, Henry M. Colecraft, Manu Ben Johny 563-Pos Board B338 PORE-BLOCKING EFFECT OF ISOINDOLINE MDIMP ON VOLTAGE-GATED CALCIUM CHANNELS.  Juan Antonio M. De La Rosa , Maricela García- Castañeda, Takuya Nishigaki, Juan Carlos Gomora, Teresa Mancilla-Perci- no, Guillermo Avila Cardiac Muscle Regulation (Boards B339 - B361) 564-Pos Board B339 TROPONIN-T CARDIOMYOPATHY MUTATIONS DEPRESS ITS INHIBITORY PROPERTIES, IN VITRO , AND STIMULATE MYOCARDIAL DYSFUNCTION, IN VIVO . Aditi Madan , Meera C. Viswanathan, Georg Vogler, Kathleen C. Woulfe, William Schmidt, Bosco Trinh, Sineej Madathil, Cortney Wilson, Larry S. Tobacman, Anthony Cammarato 565-Pos Board B340 THE EFFECT OF PHOSPHORYLATION ON THE STRUCTURE AND TOPOLOGY OF THE SERCA-PLN COMPLEX. Daniel Weber , Songlin Wang, Erik Larsen, Tata Gopinath, Gianluigi Veglia

F R I D A Y

S U N D A Y

39