Biophysical Society 63rd Annual Meeting | Program Guide

579-Pos Board B354 CARDIAC OVEREXPRESSION OF HUMAN ADENYLYL CYCLASE TYPE 8 IN MICE ELICITS PHOSPHORYLATION- DEPENDENT MECHANISMS THAT PERMIT PERPETUAL HEART EXERCISE WHILE CONFERRING PROTECTION AGAINST EXCESSIVE CAMP-PKA SIGNALING. Khalid Chakir , Alexey E. Lyas- hkov, Kirill V. Tarasov, Ismayil Ahmet, Dongmei Yang, Yelena S. Tarasova, Daniel Riordon, Yevgeniya O. Lukyanenko, Thanh Huynh, Karel Pacak, Edward G. Lakatta 580-Pos Board B355 SINGLE MOLECULE VISUALIZATION OF CARDIAC MYOSIN-BINDING PROTEIN C N-TERMINAL FRAGMENTS INTERACTING WITH REGULATED ACTIN FILAMENTS: MECHANISMS OF CALCIUM SENSITIZATION. Alessio V. Inchingolo, Samantha B. Previs, Michael J. Previs, David M. Warshaw, Neil M. Kad 581-Pos Board B356 REGULATION OF MYOFILAMENT CONTRACTILE FUNCTION IN HUMAN DONOR AND FAILING HEARTS. Kerry S. McDonald , Laurin M. Hanft, Joel C. Robinett, Maya E. Guglin, Kenneth S. Campbell 582-Pos Board B357 TRAVEL AWARDEE IN HUMAN EMBRYONIC STEM CELL-DERIVED CARDIOMYOCYTES TWITCH KINETICS, ACTION POTENTIAL PARAMETERS AND MYH -MRNA FRAC- TIONS ARE INDEPENDENT OF THE EXPRESSED MYOSIN HEAVY CHAIN ISOFORM. Natalie Weber , Kathrin Kowalski, Tim Holler, Ante Radocaj, Martin Fischer, Jeanne de la Roche, Stefan Thiemann, Kristin Schwanke, Alexander Lingk, Uwe Krumm, Birgit Piep, Ullrich Martin, Robert Zweig- erdt, Bernhard Brenner, Theresia Kraft 583-Pos Board B358 ADOLESCENT BINGE ALCOHOL EXPOSURE AFFECTS CARDIOVASCULAR FUNCTION. Lizhuo Ai, Edith Perez, Quan Cao, Maxime Heroux, Andrei Zlobin, AnnaDorothea Asimes, Toni R. Pak, Jonathan A. Kirk 584-Pos Board B359 TRAVEL AWARDEE IMPACT OF HYPERTROPHIC CARDIOMYOPATHY MUTATIONS ON THE CARDIAC MYOSIN SUPER-RELAXED STATE. Sriya Byrapuneni , Sami Chu, Joseph M. Muretta, David D. Thomas 585-Pos Board B360 A NOVEL Α-TROPOMYOSIN MUTATION (D55N) ASSOCIATED WITH FAMIL- IAL DILATED CARDIOMYOPATHY INCREASES TROPOMYOSIN BINDING TO ACTIN. Xiaomei Yang , Michelle A. Recto, Xinyu Zhang, Yuejin Li, Genaro A. Ramirez Correa, WilliamM. Schmidt, Brittney Murray, Anne M. Murphy 586-Pos Board B361 ACTIN-BINDING COMPOUNDS THAT AFFECT THE WEAK-TO-STRONG ACTIN-MYOSIN INTERACTION. Osha Roopnarine , David D. Thomas Cell Mechanics, Mechanosensing, and Motility I (Boards B362 - B387) 587-Pos Board B362 RESCUE OF DNA DAMAGE AFTER CONSTRICTED MIGRATION BY DNA REPAIR FACTOR OVEREXPRESSION. Yuntao Xia , Charlotte Pfeifer, Kuang- zheng Zhu, Jerome Irianto, Dennis Discher 588-Pos Board B363 SPATIAL SEGREGATION AND BOUNDARY FORMATION IN BREAST CANCER AGGREGATES. Alex Devanny , Daniel Lee, Laura Kaufman 589-Pos Board B364 MAPPING THE BIOCHEMICAL INTERACTIONS OF THE MECHANORESPON- SIVE CONTRACTILITY CONTROLLER. Priyanka Kothari , Vasudha Srivastava, Vasudha Aggarwal, Irina Tchernyshyov, Jennifer Van Eyk, Taekjip Ha, Douglas N. Robinson

566-Pos Board B341 DIABETES WITH HEART FAILURE INCREASES METHYLGLYOXAL MODIFICA- TIONS IN THE SARCOMERE WHICH INHIBIT FUNCTION. Maria Papadaki , Ronald Holewisnki, Sammantha Previs, Thomas Martin, Marisa Stachows- ki, Amy Li, Cheavar Blair, Kenneth Campbell, Moravec Christine, Jennifer Van Eyk, Virginie Aubert, David Warshaw, Jonathan Kirk 567-Pos Board B342 TROPONIN I TYROSINE PHOSPHORYLATION: NOVEL REGULATOR OF CARDIAC FUNCTION. Elizabeth A. Brundage, Vikram Shettigar, Ying-Hsi Lin, Brendan Agatisa-Boyle, Mark Jeong, Mark T. Ziolo, Brandon J. Biesiadecki 568-Pos Board B343 PREDICTING EFFECTS OF TROPOMYOSIN STIFFNESS ON CARDIAC MUSCLE CONTRACTION USING COARSE-GRAINED STOCHASTIC MODELING.  Yasser Aboelkassem , Kimberly J. McCabe, Michael Regnier, James B. Bassingthwaighte, Andrew D. McCulloch 569-Pos Board B344 MOLECULAR MECHANISM OF A MUTATION IMPLICATED IN PEDIATRIC- ONSET HEART DISESASE. Samantha K. Barrick , Michael J. Greenberg 570-Pos Board B345 LOSS OF BINDING BETWEEN GIANT OBSCURIN AND TITIN RESULTS IN CARDIAC MALADAPTATION. Alyssa Grogan , Li-Yen R. Hu, Christopher Ward, Aikaterini Kontrogianni-Konstantopou 571-Pos Board B346 CHARACTERIZATION OF THE ALPHA-KAP FRET BIOSENSOR TO DETER- MINE COMPARTMENTALIZED BETA-ADRENERGIC RECEPTOR CAMP SIG- NALING IN DISTINCT INTRACELLULAR LOCATIONS. Michael W. Rudokas , John P. Post, Alejandra Sataray-Rodriguez, Chase M. Fiore, Shailesh R. Agarwal, Robert D. Harvey 572-Pos Board B347 ENGINEERED THIN FILAMENT MUTATION TO INCREASE CALCIUM SENSI- TIVITY OF FORCE IN TROPOMYOSIN MUTATION OF DILATED CARDIOMY- OPATHY. Kristina B. Kooiker , Joseph D. Powers, Jil Tardiff, Michael Regnier, Jennifer Davis, Farid Moussavi-Harami 573-Pos Board B348 THE ROLE OF CARDIAC MYBPC IN REGULATING FRANK STARLING RELA- TIONSHIPS. Laurin M. Hanft , Daniel P. Fitzsimons, Timothy A. Hacker, Richard L. Moss, Kerry S. McDonald 574-Pos Board B349 RESOLVING THE ACTIN LATTICE AND IDENTIFYING THE RELATIVE POSI- TION OF MYBP-C’S N-TERMINUS IN CARDIAC MUSCLE USING STORMMI- CROSCOPY. Sheema Rahmanseresht , Kyounghwan Lee, Jeffrey Robbins, David M. Warshaw, Roger Craig, Michael J. Previs 575-Pos Board B350 MODULATION OF CALCIUM SENSITIVITY AND TWITCH CONTRACTIONS IN CARDIAC MUSCLE WITH TROPONIN-C MUTATIONS: SIMULATIONS AND EXPERIMENTS. Srboljub M. Mijailovich , Momcilo Prodanovic, Lazar Vasovic, Boban Stojanovic, Mladen Maric, Danica Prodanovic, Joseph D. Powers, Jennifer Davis, Michael A. Geeves, Michael Regnier 576-Pos Board B351 C0 IG-DOMAIN OF CARDIAC MYOSIN BINDING PROTEIN-C INTERACTS WITH THE REGULATORY LIGHT CHAIN OF MYOSIN-S1 BOUND TO THE NATIVE CARDIAC THIN FILAMENT. Cristina Risi, Betty Belknap, Samantha Harris, Howard White, Vitold E. Galkin 577-Pos Board B352 OBSCURIN IN HEART FAILURE. Aidan M. Ex-Willey , Heather R. Manring, Ahmet Kilic, Paul M.L. Janssen, Nathan T. Wright, Maegen A. Ackermann 578-Pos Board B353 BIOPHYSICS OF SERCA2A DWORF COMPLEX AND IMPLICATIONS FOR THERAPEUTIC DESIGN. Ang Li , Daniel Stroik, Tory Schaaf, David D. Thomas

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