Biophysical Society 63rd Annual Meeting | Program Guide

Calcium Signaling (Boards B270 - B294) 1168-Pos Board B270 THE ROLE OF PHOSPHOFRUCTOKINASE-M (PFKM) IN OSCILLATORY GLY- COLYSIS AND INSULIN SECRETION IN PANCREATIC BETA CELLS. Vishal S. Parekh , Jim Ren, Leslie S. Satin 1169-Pos Board B271 BIPHASIC CA 2+ REGULATION OF SK CHANNELS IN VENTRICULAR CARDIO- MYOCYTES MAXIMIZES THEIR CONDUCTANCE DURING A LATE PHASE OF THE ACTION POTENTIAL. Peter Bronk , Iuliia Polina, Radmila Terentyeva, Shanna Hamilton, Dmitry Terentyev 1170-Pos Board B272 COMPUTATIONAL MODELING OF PURINERGIC RECEPTOR ACTIVATION IN MICROGLIA. Peter M. Kekenes-Huskey , Byeongjae Chun, Darin Vaughan 1171-Pos Board B273 TRAVEL AWARDEE THE ROLE OF DOPAMINE IN PANCREATIC Α-CELLS CALCIUM HETEROGE- NEITY AND SYNCHRONIZATION MEASURED BY LIGHT-SHEET MICROS- COPY. Zeno Lavagnino , David W. Piston 1172-Pos Board B274 CARDIAC STORE OPERATED CALCIUM ENTRY (SOCE) IS COMPARTMEN- TALIZED AT INTERCALATED DISKS AND LINKED TO CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA (CPVT).  Ingrid M. Bonilla Mercado , Andriy Belevych, Stephen Baine, Tom Bodnar, Bin Liu, Przemys- law Radwanski, Rengansayee Veeraraghavan, Pompeo Volpe, Silvia Priori, Noah Weisleder, Sandor Gyorke 1173-Pos Board B275 DIURNAL PROPERTIES OF VOLTAGE-GATED CALCIUM CURRENTS IN SCN. Beth McNally, Andrea Meredith 1174-Pos Board B276 ROLE OF ORAI1 AND STORE OPERATED CALCIUM ENTRY (SOCE) IN LIVER: EFFECTS ON HORMONE-INDUCED CALCIUM SIGNALING AND GLUCOSE METABOLISM. Gary S. Bird , Diane D’Agostin, Pooja Desai, James W. Board B277 FUNCTIONAL CONNECTOME OF THE MECHANICALLY LOADED CARDIO- MYOCYTE I: IDENTIFYING INVOLVED SUBSYSTEMS. Zana A. Coulibaly , Leighton Izu, Ye Chen-Izu, Zhong Jian, Rafael Shimkunas 1176-Pos Board B278 CRISPR/CAS9 ENGINEERED Q3925E-RYR2 MUTATION IN HUMAN INDUCED PLURIPOTENT STEM CELLS IMPAIRS CAFFEINE TRIGGERED CA 2+ RELEASE. Xiaohua Zhang, Hua Wei, Naohiro Yamaguchi, Martin Morad 1177-Pos Board B279 MYOCARDIAL RAD DELETION MODULATES L-TYPE CALCIUM CHANNEL CURRENT. Brooke Ahern , Mihir Shah, Andrea Sebastian, Douglas A. Andres, Jonathan Satin 1178-Pos Board B280 MODELING THE IMPACT OF SPINE APPARATUS ON SIGNALING AND REGULATION IN REALISTIC DENDRITIC SPINE GEOMETRIES. Justin G. Laughlin, Christopher T. Lee , J. AndrewMcCammon, Rommie E. Amaro, Michael Holst, Padmini Rangamani 1179-Pos Board B281 THE ROLE OF S-ACYLATION IN STORE OPERATED CALCIUM ENTRY.  Savannah J. West , Qiaochu Wang, Michael X. Zhu, Askar M. Akimzhanov, Darren Boehning Putney Jr. 1175-Pos

1180-Pos Board B282 INHIBITION OF CA 2+ INFLUX BY SARAF AND PANCREATITIS. Aran Son, Shmuel Muallem, Malini Ahuja 1181-Pos Board B283 CA 2+ DIFFUSION IN THE LARGE PEPTIDERGIC NERVE TERMINALS OF THE POSTERIOR PITUITARY. Shane M. McMahon , Meyer B. Jackson 1182-Pos Board B284 MITOCHONDRIAL CALCIUM SIGNALING IN HEART. Andrew P. Wescott , Joseph P. Kao, W. Jonathan Lederer, Liron Boyman 1183-Pos Board B285 IDENTIFICATION AND CHARACTERIZATION OF AN NAADP RECEPTOR ESSENTIAL FOR NAADP-EVOKED CALCIUM RELEASE FROM ENDOLYSO- SOMAL ORGANELLES.  Jiyuan Zhang , Xin Guan, Jiusheng Yan 1184-Pos Board B286 NULL-SARCOLIPIN EQUINE MUSCLE SHOWS ENHANCED SERCA CALCIUM TRANSPORT WHICH MAY POTENTIATE THE PREVALENCE OF EXERTIONAL RHABDOMYOLYSIS.  Joseph M. Autry , Bengt Svensson, Christine B. Karim, Sudeep Perumbakkam, Zhenhui Chen, Carrie J. Finno, David D. Thomas, Stephanie J. Valberg 1185-Pos Board B287 MIR-200C EXHIBITS AN AGE-DEPENDENT INCREASE IN THE RAT HEART AND MODULATES CARDIOMYOCYTE FUNCTION. Cristina Florio , Ales- sandra Magenta, Rostislav Byshkov, Kenta Tsutsui, Bruce Ziman, Edward G. Lakatta, Maurizio C. Capogrossi 1186-Pos Board B288 POTENTIAL NEUROPROTECTIVE DRUG EVP4593 REDUCES EXCESSIVE EXPRESSION OF HUNTINGTIN IN IPSC-BASED JUVENILE MODEL OF HUNTINGTON’S DISEASE. Dmitry Grekhnyov , Vladimir Vigont, Elena Kaznacheyeva 1187-Pos Board B289 A COMPUTATIONAL FRAMEWORK TO STUDY THE KINETICS AND EVOLU- TION OF CA 2+- PERMEABLE Β AMYLOID PORES ASSOCIATED WITH AL- ZHEIMER’S DISEASE. Syed Islamuddin Shah , Ian Parker, Angelo Demuro, Ghanim Ullah 1188-Pos Board B290 PROBING THE MECHANISMS BY WHICH SEPTINS REGULATE ORAI1 FUNC- TION. Zachary Katz, Chen Zhang , Ariel Quintana, Bjorn Lillemeier, Patrick Board B291 PADE APPROXIMATION OF SINGLE-CHANNEL CALCIUM NANODOMAINS IN THE PRESENCE OF COOPERATIVE CALCIUM BUFFERS. Yinbo Chen, Victor Matveev 1190-Pos Board B292 NEW RED FLUORESCENT CALCIUM INDICATORS FOR FUNCTIONAL ANALY- SIS OF GPCRS AND CA 2+ CHANNEL TARGETS. Qin Zhao , Haitao Guo, Peng Ruogu, Liu Jixiang, Jinfang Liao, Zhenjun Diwu 1191-Pos Board B293 THE ARRHYTHMOGENIC E105A CAMMUTATION DYSREGULATES NOR- MAL CARDIAC FUNCTION IN ZEBRAFISH BY ALTERING CAM-CA 2+ AND CAM-RYR2 INTERACTIONS. Michail Nomikos , Sahar I. Da’as, Angelos Thanassoulas, Rola Salem, Brian L. Calver, Alaaeldin Saleh, Ali Al-Maraghi, Gheyath K. Nasrallah, Bared Safieh-Garabedian, Egon Toft, George Nounesis, F. Anthony Lai 1192-Pos Board B294 CALCIUM CHANNELS CONTRIBUTING TO ACTION POTENTIAL FIRING AND RHYTHMS IN THE CIRCADIAN CLOCK. Amber E. Plante , Andrea L. Meredith G. Hogan 1189-Pos

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