Biophysical Society 63rd Annual Meeting | Program Guide

1218-Pos Board B320 REPURSPOSING THE KCA3.1 BLOCKER SENICAPOC AS A MICROGLIA-TAR- GETED THERAPEUTIC FOR ALZHEIMER’S DISEASE. Heike Wulff , Jacopo Di Lucente, Hai M. Nguyen, Vikrant Singh, Lee-Way Jin, Izumi Maezawa 1219-Pos Board B321 PRODUCTION OF NATIVE-LIKE REFOLDED NA V 1.7 VOLTAGE SENSING DOMAIN AS SHOWN BY TOXIN BINDING ACTIVITY. Ryan V. Schroder , Ping Wang, Sebastien F. Poget 1220-Pos Board B322 ALL OPTICAL INTERROGATION OF VOLTAGE GATED SODIUM CHANNELS USING NEXT GENERATION FAST VOLTAGE SENSITIVE DYES IN A SYSTEM SUITABLE FOR HIGH THROUGHPUT SCREENING. Stephen S. Smith , An- drew Blatz, Thomas Lila, James Limberis, Jay Trautman 1221-Pos Board B323 MECHANICAL STRETCH INCREASES KV1.5 POTASSIUM CHANNEL ACTIV- ITY THROUGH A SIGNALING CASCADE INVOLVING N-TERMINUS OF THE CHANNEL. Alexandria O. Milton 1222-Pos Board B324 MODELING TRAPPING BLOCK OF HERG FOR CIPA: DOES THE BASAL HERG MODE MATTER? Brandon Franks, Mark Nowak, Brian Panama, Randall Rasmusson, Glenna Bett 1223-Pos Board B325 SMOOTH MUSCLE KV11.1 CHANNEL EXPRESSION IS INCREASED IN PUL- MONARY HYPERTENSION. Nataliia V. Shults , Vladyslava Rybka, Yuichiro J. Suzuki, Tinatin I. Brelidze 1224-Pos Board B326 A DE NOVO MUTATION ASSOCIATED WITH EPILEPSY ENHANCES K V 1.2 VOLTAGE DEPENDENCE, SUPPRESSING NEURONAL EXCITABILITY.  Antonios Pantazis , Maki Kaneko, Annie M. Westerlund, Lucie Delemotte, Sulagna Saitta, Riccardo Olcese 1225-Pos Board B327 ATOMISTIC COMPUTATIONAL MODELS TO PREDICT DRUG-MEDIATED CARDIOTOXICITY. Khaled H. Barakat 1226-Pos Board B328 VOLTAGE- AND STATE-DEPENDENT BLOCKADE OF HERG POTASSIUM CHANNELS BY FENTANYL.  Jared Tschirhart , Wentao Li, Jun Guo, Shetuan Zhang 1227-Pos Board B329 PHOTODYNAMIC MODIFICATION OF NATIVE HCN CHANNELS IN THALA- MOCORTICAL NEURONS. Fusheng Wei, Qiang Wang, Ankush Gupta, Qinglian Liu, Lei Zhou 1228-Pos Board B330 A NOVEL HIGH-THROUGHPUT SCREENING ASSAY FOR STATE-DEPENDENT AND SUBUNIT-DEPENDENT BK CHANNEL MODULATORS. Frank T. Horrigan , Lorie A. Gonzalez, Liang Sun, Michael Bloch, Shengwei Zou 1229-Pos Board B331 IDENTIFYING NOVEL KCNH CHANNEL LIGANDS WITH SURFACE PLAS- MON RESONANCE METHOD. Purushottam Tiwari, Aykut Uren, Tinatin I. Brelidze 1230-Pos Board B332 IPSC-DERIVED MOTOR NEURONS ON THE AUTOMATED PATCH CLAMP PLATFORMS QUBE AND QPATCH. Kadla R. Rosholm , Melanie Schupp 1231-Pos Board B333 INSIGHTS INTO SELECTIVITY FILTER GATING OF K2P CHANNELS FROM SINGLE-CHANNEL RECORDINGS. Linus J. Conrad , Stephen J. Tucker

1232-Pos Board B334 INITIAL CHARACTERIZATION OF THE INDOLE-3-CARBOXAMIDE BIC-154 AS A FAST ONSET AND REVERSIBLE ORAI CHANNEL BLOCKER. Tetyana Zhelay, Kalina Szteyn , Elisa Liardo, Jae Eun Cheong, Steffi Koerner, Anil Ekkati, Lijun Sun, J. Ashot Kozak 1233-Pos Board B335 HUMAN CFTR CHANNEL FUNCTION IS REGULATED BY CHOLESTER- OL. Guiying Cui , Kirsten A. Cottrill, Kerry A. McGill, Barry Imhoff, Nael A. McCarty 1234-Pos Board B336 ACTIVATION OF POTASSIUM CHANNEL AS A NEW STRATEGY TO BOOST ANTITUMOUR IMMUNE RESPONSE. Seow Theng Ong , Aik Seng Ng, Xuan Rui Ng, Lindsay Kua, Fiona YX Lee, Siqi Tan, Heesung Shim, Praseetha Prasannan, Ramanuj DasGupta, Iain BH Tan, Heike Wulff, K George Chandy, Navin K. Verma 1235-Pos Board B337 NOVEL INHIBITORS OF THE CALCIUM-ACTIVATED K + CHANNEL K CA 3.1 TO TREAT NON-ALCOHOLIC FATTY LIVER DISEASE AND LIVER FIBROSIS. Seow Theng Ong , Gemma Thomas, Srinivasaraghavan Kannan, Zhisheng Her, Xuan Rui Ng, Xinying Chew, Hai M. Nguyen, Heike Wulff, Chandra Verma, Qingfeng Chen, Mahmood Ahmed, K George Chandy 1236-Pos Board B338 STRUCTURAL MODELING OF DRUG INTERACTIONS WITH HERG CHANNEL IN OPEN AND CLOSED STATES. Aiyana M. Emigh , Kevin R. DeMarco, Ka- zuharu Furutani, Jon T. Sack, Colleen E. Clancy, Igor V. Vorobyov, Vladimir Yarov-Yarovoy 1237-Pos Board B339 BENEFICIAL EFFECT OF MITOCHONDRIAL CALCIUM UNIPORTER OVER- EXPRESSION IN A GUINEA PIG HEART FAILURE AND SUDDEN CARDIAC DEATH MODEL. Ting Liu , Brian O’Rourke 1238-Pos Board B340 TRAVEL AWARDEE IRTUINS POSITIVELY REGULATE K ATP CHANNELS, WHICH CONTRIBUTES TO THEIR CARDIOPROTECTIVE ROLE. Erkan Tuncay , Hua-Qian Yang, Ivan Gando, Belma Turan, Ravichandran Ramasamy, William A. Coetzee 1239-Pos Board B341 TRAVEL AWARDEE PROBING KV1.3 INTERACTOME WITH PROXIMITY-DEPENDENT BIOTINYL- ATION. Vanessa Checchetto , Elena Prosdocimi, Roberta Peruzzo, JESUSA CAPERA ARAGONES, Luigi Leanza, Antonio Felipe, Ildikò Szabò 1240-Pos Board B342 INHIBITION OF CONNEXION HEMICHANNELS BY NEW AMINOGLYCO- SIDES WITHOUT ANTIBIOTIC ACTIVITY. Abbey Kjellgren , Mariana C. Fiori, Madher N. AlFindee, Yagya P. Subedi, Srinivasan Krishnan, Cheng-Wei T. Chang, Guillermo A. Altenberg Cytoskeletal Assemblies & Dynamics (Boards B343 - B357) 1241-Pos Board B343 STRUCTURAL MODEL FOR PREFERENTIAL MICROTUBULE MINUS END BINDING BY CAMSAP CKK DOMAINS. Joseph Atherton, Yanzhang Luo, Shengqi Xiang, Chao Yang, Annapurna Vemu, Marcel Stangier, Alexander Cook, Shana Wang, Kai Jiang, Michel Steinmetz, Antonina Roll-Mecak, Anna Akhmanova, Marc Baldus, Carolyn A. Moores 1242-Pos Board B344 TRAVEL AWARDEE A DYNAMIC TIME STEP METHOD IN CYTOSKELETAL SIMULATIONS.  Joseph Tibbs , A. Pasha Tabatabai, Daniel S. Seara, Ali Tabei, Michael P. Murrell 1243-Pos Board B345 RAPID TREADMILLING AND MYOSIN MOTORS SYNERGISTICALLY INDUCE FORMATION OF RING-LIKE ACTOMYOSIN ARCHITECTURES AND CORTEX- ES. Qin Ni , Arpita Upadhyaya, Garegin A. Papoian

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