Biophysical Society 63rd Annual Meeting | Program Guide

1295-Pos Board B397 MYOFILAMENT LENGTH DEPENDENT ACTIVATION IN PORCINE CARDIAC MUSCLE. Weikang Ma , Robert Anderson, Marcus Henze, Henry Gong, Fiona Wong, Carlos del Rio, Thomas Irving 1296-Pos Board B398 ANNULMENT OF CARDIAC MUSCLE LENGTH-DEPENDENT FORCE ACTIVA- TION IN TRANSGENIC MICE BEARING THE HCTNT-I79N MUTATION.  Maicon Landim Vieira , Bjorn Knollmann, Hyun S. Hwang, J. Renato Pinto, P. Bryant Chase 1297-Pos Board B399 DEVELOPMENT OF AN ATOMISTIC STRUCTURE OF MYOSIN BOUND CAR- DIAC THIN FILAMENT AND FREE ENERGY DETERMINATION OF THE CLOSE TO OPEN TRANSITION. Anthony Baldo , Steven D. Schwartz 1298-Pos Board B400 THE OFF-TO-ON TRANSITION OF THICK FILAMENTS IN ISOLATED TRA- BECULAE FROM RAT HEART INDUCED BY COOLING.  Jesus Garcia Ovejero , Luca Fusi, So-Jin Park-Holohan, Andrea Ghisleni, Theyencheri Narayanan, Malcolm Irving, Elisabetta Brunello 1299-Pos Board B401 ANTI-S2 PEPTIDES MODULATE MYOSIN COILED COIL STRUCTURE AND SHIFT FORCE- P CA CURVES IN HUMAN CARDIAC MUSCLE. Bertrand C.W. Tanner, Kenneth S. Campbell, Motamed Qadan, Negar Aboonasrshiraz, Dua’a Quedan, Peter O. Awinda, Andrea Bernardino-Shaefer, Douglas D. Root 1300-Pos Board B402 IMPACT OF HUMAN BETA-CARDIAC MYOSIN MUTATION IMPLICATED IN BOTH HYPERTROPHIC AND DILATED CARDIOMYOPATHY. Wanjian Tang , Laura K. Gunther, Jonathan Cooper, Rohini Desetty, Christopher M. Yengo 1301-Pos Board B403 MOLECULAR DYNAMICS STUDIES OF SINGLE POINT MUTATIONS IN THE CARDIAC THIN FILAMENT. Allison B. Smith , Anthony Baldo, Natercia Braz, Steven D. Schwartz 1302-Pos Board B404 DESIGN OF BIOCOMPATIBLE LIQUID CRISTAL ELASTOMERS REPRODUCING THE MECHANICAL PROPERTIES OF HUMAN CARDIAC MUSCLE. Cecilia Ferrantini, J. Manu Pioner, Daniele Martella, Raffaele Coppini, Nicoletta Piroddi, Paolo Paoli, Martino Calamai, Francesco S. Pavone, Diederik Wiersma, Chiara Tesi, Elisabetta Cerbai 10 , Corrado Poggesi 11 , Leonardo Sacconi , Camilla Parmeggiani 1303-Pos Board B405 HUMAN BETA-CARDIAC MYOSIN CARDIOMYOPATHY MUTATIONS R712L AND E497D DISRUPT A KEY SALT-BRIDGE IN THE COUPLING DOMAIN.  Bipasha Barua , Jennifer L. Atherton, Eva Forgacs, Donald A. Winkelmann 1304-Pos Board B406 ISOLATING THE PATHOLOGICAL CONTRIBUTION OF DETYROSINATED MICROTUBULES IN HUMAN MYOCARDIAL MECHANICS. Matthew A. Caporizzo , Christina Y. Chen, Kenneth Bedi, Kenneth B. Margulies, Benja- min L. Prosser 1305-Pos Board B407 TRAVEL AWARDEE PREDICTING AND PREVENTING MYOCARDIAL REMODELING IN A MURINE MODEL OF DILATED CARDIOMYOPATHY.  Joseph D. Powers , Galina Flint, Jil Tardiff, Michael Regnier, Farid Moussavi-Harami, Jennifer Davis 1306-Pos Board B408 MOLECULAR DYNAMICS STUDIES OF MYOSIN STRUCTURE WITH 2-DEOXY-ADP. Matthew C. Childers , Weikang Ma, Valerie Daggett, Mike Regnier

1307-Pos Board B409 COMPUTATIONAL AND EXPERIMENTAL INVESTIGATION OF CARDIAC TROPONIN T R173Q, R173W AND Δ160E MUTATION SPECIFIC CORRE- LATES TO DISEASE. Andrea E. Deranek , Anthony Baldo, Steven Schwartz, Jil C. Tardiff 1308-Pos Board B410 THE ROLE OF GSK3B MISLOCALIZATION IN ARRYTHMOGENIC CARDIOMY- OPATHY. Ronald Ng , Stuart Campbell 1309-Pos Board B411 ISOMETRIC AND ISOTONIC TWITCH DYNAMICS IN OMECAMTIV MER- CARBIL TREATED INTACT RAT CARDIAC TRABECULA. Brianna M. Schick, Alexandra R. Matus, Charles S. Chung 1310-Pos Board B412 MULTI-TIMEPOINT RNA-SEQUENCING REVEALS DIFFERENTIAL GENE EXPRESSION OF TRANSGENIC MOUSE MODELS OF HYPERTROPHIC AND DILATED CARDIOMYOPATHIES. Shivani H. Desai , Jil C. Tardiff, Melissa L. Lynn, Amanda M. Richards 1311-Pos Board B413 HUMAN CARDIAC MYOSIN-BINDING PROTEIN C N-TERMINAL DOMAINS COOPERATIVELY IMPACT ACTIN STRUCTURAL DYNAMICS. Rhye-Samuel Kanassatega , Thomas A. Bunch, Victoria C. Lepak, Brett A. Colson 1312-Pos Board B414 THE HCM-CAUSING Y235S CMYBPC MUTATION ACCELERATES CONTRAC- TILE FUNCTION BY ALTERING C1 DOMAIN STRUCTURE. Chang Yoon Doh , Jiayang Li, Ranganath Mamidi, Julian E. Stelzer 1313-Pos Board B415 MICROTUBULE ACETYLATION REGULATES CONTRACTILE KINETICS OF STRIATED MUSCLE. Andrew K. Coleman , Humberto C. Joca, George S.B. Williams, W. Jonathan Lederer, Chris W. Ward Mitochondria in Cell Life and Death (Boards B416 - B443) 1314-Pos Board B416 MITOCHONDRIAL METABOLIC FUNCTION IS AFFECTED BY INNER MEMBRANE MORPHOLOGY. Nasrin Afzal , Carmen Mannella, William J. Lederer, Mohsin S. Jafri 1315-Pos Board B417 AN AUTOMATED METHOD FOR SEGMENTING HIGHLY CONVOLUTED MITOCHONDRIAL INNER MEMBRANES FROM ELECTRON MICROSCOPIC TOMOGRAMS. Raquel Adams , Zheng Liu, Carmen A. Mannella, W. Jona- than Lederer, M. Saleet Jafri 1316-Pos Board B418 TRAVEL AWARDEE OPTOGENETIC REGULATION OF MITOCHONDRIAL FUNCTION AND SYNAPTIC PLASTICITY IN VIVO. Kristian M. Zapata , Illya Aronskyy, Stephen Madamba, Pablo M. Peixoto 1317-Pos Board B419 DRUG SCREENING AND DISCOVERY STRATEGIES AT NANOSCALE MOR- PHOLOGY USING STRUCTURED ILLUMINATION MICROSCOPY. Xintian Shao , Qixin Chen, Peixue Ling, Jiajie Diao 1318-Pos Board B420 QUANTITATIVE ANALYSIS OF INTERACTIVE BEHAVIOR OF MITOCHONDRIA AND LYSOSOMES USING STRUCTURED ILLUMINATION MICROSCOPY.  Qixen Chen , Xintian Shao, Peixue Ling, Jiajie Diao 1319-Pos Board B421 MODELING THE INSERTION OF HEXOKINASE IN THE MITOCHONDRIAL OUTER MEMBRANE AND ITS COMPLEX FORMATION WITH VDAC.  Nandan Haloi , Po-Chao Wen, Amadou KS Camara, Wai-Meng Kwok, Emad Tajkhorshid

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