Biophysical Society 63rd Annual Meeting | Program Guide

1272-Pos Board B374 MECHANICAL STABILITY OF MICROTUBULE LATTICES - MOLECULAR DYNAMIC INDENTATION STUDIES. Lukasz Szatkowski , Merz Jr. R. Dale, Jennifer L. Ross, Ruxandra I. Dima 1273-Pos Board B375 MODULATION OF MICROTUBULE CURVATURE UNDER DIFFERENT CEL- LULAR CONDITIONS REVEALED BY IN-CELL CERYO-ELECTRON TOMOGRA- PHY.  Julia Mahamid , Saikat Chakraborty, Wolfgang Baumeister 1274-Pos Board B376 STRUCTURAL STUDIES OF CAP-GLY DOMAIN OF DYNACTIN ASSEMBLED WITH MICROTUBULES BY MAGIC ANGLE SPINNING NMR SPECTROSCO- PY. Changmiao Guo , John C. Williams, Tatyana Polenova 1275-Pos Board B377 TRAVEL AWARDEE TOWARDS AN UNDERSTANDING OF KIDNEY DISEASES ASSOCIATED WITH INHIBITION OF NOTCH SIGNALING PATHWAY BY TRANSMISSION ELEC- TRON MICROSCOPY.  Ishara Ratnayake , Steve Smith, Indra Chandrasekar, Kameswaran Surendran, Phil Ahrenkiel 1276-Pos Board B378 TOPOLOGICAL PHONONS IN MICROTUBULES: THE LINK BETWEEN LOCAL STRUCTURE AND DYNAMICS OF MICROTUBULES. Arooj Aslam , Ssu-Ying Chen, Emil Prodan, Camelia Prodan 1277-Pos Board B379 RECONSTITUTION OF POM1 GRADIENT IN ELONGATED DROPLETS. Renu Vishavkarma 1278-Pos Board B380 COMPUTATIONAL STUDY OF ABL PATHWAY BASED AXONAL GUID- ANCE. Aravind Chandrasekaran , Garegin A. Papoian, Edward Giniger Myosins and Smooth Muscle Mechanics, Structure, and Regulation (Boards B381 - B391) 1279-Pos Board B381 ATOMICALLY DETAILED SIMULATION OF THE POWERSTROKE IN MYOSIN II BY MILESTONING. Katelyn Poole , Ron Elber 1280-Pos Board B382 OPTICAL CONTROL OF FAST AND PROCESSIVE ENGINEERED MYOSINS IN VITRO AND IN LIVING CELLS. Paul V. Ruijgrok , Rajarshi P. Ghosh, Mu- neaki Nakamura, Sasha Zemsky, Robert Chen, Vipul Vachharajani, Jan T. Liphardt, Zev Bryant 1281-Pos Board B383 TRACKING OF LABELED MOTOR DOMAINS OF SINGLE FULL-LENGTH MYOSIN X ON ACTIN BUNDLES. Xianan Qin , Harry Chun Man Cheng, Jing Li, Hanna Yoo, Xiaoyan Liu, Tianming Lin, H. Lee Sweeney, Hyokeun Park 1282-Pos Board B384 THE ROLE OF NON-MUSCLE MYOSIN 2A AND 2B IN THE REGULATION OF MESENCHYMAL CELL CONTACT GUIDANCE. Alexander S. Zhovmer , Er- dem Tabdanov, Houxun Miao, Han Wen, Jinqiu Chen, Xiaoling Luo, Xuefei Ma, Paolo Provenzano, Robert Adelstein 1283-Pos Board B385 ELECTROSTATIC INTERACTIONS WITHIN LOOP 1 AND THE FORCE GEN- ERATION REGION OF HUMAN CARDIAC MYOSIN AFFECT THE RATE OF ACTOMYOSIN DISSOCIATION AND ADP RELEASE. Akhil Gargey , Jinghua Ge, Alex Grdzelishvili, Yaroslav Tkachev, Yuri E. Nesmelov

1284-Pos Board B386 TARGETING MECHANORESPONSIVE PROTEINS IN PANCREATIC CANCER: 4-HYDROXYACETOPHENONE BLOCKS DISSEMINATION AND INVASION BY ACTIVATING MYH14. Alexandra Surcel , Eric S. Schiffhauer, Dustin G. Thomas, Qingfeng Zhu, Kathleen DiNapoli, Maik Herbig, Oliver Otto, Angela Jacobi, Martin Kräter, Katarzyna Plak, Jochen Guck, Elizabeth M. Jaffee, Pablo A. Iglesias, Robert A. Anders, Douglas N. Robinson 1285-Pos Board B387 STATE DEPENDENT DYNAMIC COUPLING IN MYO1B DURING THE FORCE SENSITIVE TRANSITION AND MGADP RELEASE. Ahmet Mentes , Henry Shuman, E. Michael Ostap 1286-Pos Board B388 THE S217A MUTANT SLOWS THE POWER STROKE AND PHOSPHATE RELEASE IN MYOSIN V. Laura K. Gunther, Wanjian Tang, Christopher M. Yengo 1287-Pos Board B389 DECIPHERING LOAD-INDUCED ANCHORING BY MYOSIN VI. Rosemarie E. Gough , Natalia Fili, Yukti Hari Gupta, Christopher P. Toseland 1288-Pos Board B390 KINETIC MODEL FOR MYOSIN GATING AND BACKWARD STEPPING MECHANISMS. Mauro L. Mugnai , Matthew A. Caporizzo, Yale E. Gold- man, Dave Thirumalai 1289-Pos Board B391 AGING ALTERS FUNCTIONAL PROPERTIES OF CELL-MATRIX ADHESIONS IN VASCULAR SMOOTH MUSCLE CELLS. Harini Sreenivasappa, Briana Bywa- ters, Samuel Padgham, Song Yi Shin, Jerome P. Trzeciakowski, Christopher R. Woodman, Andreea Trache Cardiac Muscle Mechanics and Structure (Boards B392 - B415) 1290-Pos Board B392 MYOSIN BINDING PROTEIN H-LIKE REGULATES MYOFILAMENT CON- TENT IN ATRIAL AND A SUBSET OF VENTRICULAR CONDUCTION SYSTEM CARDIOMYOCYTES. David Y. Barefield , Sheema Rahmanseresht, Thomas O’Leary, Jordan J. Sell, Megan J. Puckelwartz, Lisa D. Wilsbacher, Michael J. Previs, Elizabeth M. McNally 1291-Pos Board B393 DATP REDUCES THE DEPRESSIVE EFFECT OF ACIDOSIS ON CARDIAC AND SLOW TWITCH SKELETAL MUSCLE. Saffie Mohran , Mike Woodward, Romi Castillo, MatthewWhithers, Valerie Daggett, Edward Debold, Michael Regnier 1292-Pos Board B394 THE MECHANISTIC ROLE OF TROPOMYOSIN OVERLAP DYSREGULATION IN EARLY CARDIOMYOPATHIC DISEASE PROGRESSION. Melissa L. Lynn , Teryn A. Holeman, Lauren Tal-Grinspan, Andrea Deranek, Jil C. Tardiff 1293-Pos Board B395 MYOSIN AND MYBP-C-MUTATIONS IN HYPERTROPHIC CARDIOMYOPA- THY: VARIABLE EFFECTS ON CALCIUM SENSITIVITY AND CONTRACTILE IMBALANCE FROM CELL TO CELL. Mirza Makul, Ante Radocaj, Pia Ernst- berger, Judith Montag, Kathrin Kowalski, Britta Keyser, Andreas Perrot, Cris G. dos Remedios, Bernhard Brenner, Theresia Kraft 1294-Pos Board B396 POWER-LOAD CHARACTERISTICS OF HUMAN-DERIVED ENGINEERED HEART TISSUE IN RESPONSE TO CARDIOMYOPATHY MUTATIONS AND MYOSIN-TARGETED DRUGS. Lorenzo R. Sewanan , Stuart G. Campbell

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