Biophysical Society 63rd Annual Meeting | Program Guide

1494-Plat 9:45 am MATRIX CA 2+ MODULATES MITOCHONDRIAL UNIPORTER (MCU) ACTIV- ITY BY FLUX-THROUGH EFFECTS.  Horia Vais , Riley Payne, Don-On Daniel Mak, Kevin J. Foskett 1495-Plat 10:00 am A NON-CANONICAL VSD-PORE COUPLING IN KCNQ CHANNELS.  Panpan Hou , Jingyi Shi, Jianmin Cui Platform Molecular Dynamics II 8:15 am - 10:15 am, Room 309/310 Co-Chairs Lucie Delemotte, KTH Royal Institute of Technology, Sweden Joseph Rudzinski, Max Planck Institute, Germany 1496-Plat 8:15 am FINDING MULTIPLE REACTION PATHWAYS VIA GLOBAL OPTIMIZATION OF ACTION.  Juyong Lee , In-Ho Lee, InSuk Joung, Jooyoung Lee, Bernard R. Brooks 1497-Plat 8:30 am ROBUST ESTIMATION OF FREE ENERGY LANDSCAPES FROM GAUSSIAN MIXTURE MODELS WITH CROSS-VALIDATION.  Lucie Delemotte , Annie M. Westerlund, Christian Blau 1498-Plat 8:45 am IMPROVED PHYSICAL MODELS ENABLE THE INVESTIGATION OF MO- LECULAR RECOGNITION IN INTRINSICALLY DISORDERED PROTEINS AT ATOMISTIC RSOLUTION.  Paul Robustelli , Stefano Piana-Agostinetti, Alain Ibáñez de Opakua, Fabrizio Giordanetto, Cecily K. Campbell-Bezat, Stefan Becker, Albert C. Pan, Markus Zweckstetter, David E. Shaw 1499-Plat 9:00 am ACCURATE ESTIMATION OF PROTEIN-BINDING KINETICS USING MARKOV STATE MODELS.  Youngchan Kim , Tiara A. Maula, Jeetain Mittal 1500-Plat 9:15 am BROWNIAN DYNAMICS STUDY OF CAMP DEGRADATION IN PHOSPHODI- ESTERASE AND ENZYME METABOLON IN THE TCA CYCLE.  Yu-ming Mindy Huang , Gary Huber, James McCammon 1501-Plat 9:30 am CONFORMATIONALLY-DEPENDENT SURFACE HOPPING FOR REPRODUC- ING STRUCTURAL CROSS-CORRELATIONS WITH COARSE-GRAINED MOD- ELS.  Tristan Bereau, Joseph F. Rudzinski 1502-Plat 9:45 am MULTISCALE MODELING FOR PEPTIDE SELF-ASSEMBLY.  Xiaochuan Zhao, Chenyi Liao, Jianing Li 1503-Plat 10:00 am BRIDGING THE SCALES: A MACHINE LEARNING DIRECTED MACRO TO MICRO SCALE SIMULATION TO MODEL RAS INITIATION OF CANCER.  Helgi I. Ingolfsson , Dwight V. Nissley, Fred Streitz Platform Biophysics and Neuroscience 8:15 am - 10:15 am, Room 314/315 Co-Chairs Padmini Rangamani, University of California, San Diego Ann-Sofie Cans, Chalmers University of Technology, Sweden 1504-Plat 8:15 am DENDRITIC SPINE GEOMETRY AND ULTRASTRUCTURE DICTATE THE SPA- TIOTEMPORAL DYNAMICS OF SECOND MESSENGERS.  Padmini Rangamani , Miriam Bell, Andrea Cugno, Donya Ohadi, Thomas M. Bartol, Ravi Iyengar, Terrence J. Sejnowski

1483-Plat TRAVEL AWARDEE CLC ANTIPORTER DIMERIZATION DYNAMICS REVEALED BY NOVEL DEVEL- OPMENTS IN HIGH-SPEED AFM.  George R. Heath , Janice L. Robertson, Simon Scheuring 1484-Plat 9:15 am A MULTI-STATE COARSE-GRAINED SIMULATION MODEL CAPTURES CONFORMATIONAL CYCLING IN P-TYPE ATPASES.  Yong Wang , Noureldin Saleh, Xiakun Chu, Kresten Lindorff-Larsen 1485-Plat 9:30 am FAST, ATOMIC-LEVEL AFM AND MAGNETIC TWEEZERS SIMULATIONS OF THE UNFOLDING OF MEMBRANE PROTEINS USING A NEWMEMBRANE BURIAL POTENTIAL WITH H-BONDING.  Zongan Wang , John M. Jumper, Karl F. Freed, Tobin R. Sosnick 1486-Plat 9:45 am CONTROLLING THE FOLDING AND MISFOLDING OF POTASSIUM CHAN- NELS.  Kevin C. Song , Younghoon Koh, Eduardo Perozo, Benoit Roux, Tobin R. Sosnick 1487-Plat 10:00 am CHIMERIC HCN CHANNELS FOR STUDYING CAMP-INDUCED CONFORMA- TIONAL CHANGES IN THE C-LINKER.  Bianca Introini , Andrea Saponaro, Alessio Bonucci, Oliver Rauh, Francesca Cantini, Lucia Banci, Gerhard Thiel, Anna Moroni Platform Ion Channel Regulatory Mechanisms 8:15 am - 10:15 am, Room 307/308 Co-Chairs Anna Moroni, University of Milan, Italy Panpan Hou, Washington University in St. Louis 1488-Plat 8:15 am STRUCTURAL RESPONSE OF THE PIEZO CHANNEL UPON APPLICATION OF FORCE.  Yi-Chih Lin , Yusong R. Guo, Atsushi Miyagi, Jesper Levring, Roderick MacKinnon, Simon Scheuring 1489-Plat 8:30 am CHARACTERIZATION OF TEMPERATURE-DEPENDENT GATING IN ARCHAE- BACTERIAL CALCIUM ACTIVATED POTASSIUM CHANNEL.  Yihao Jiang , Baron Chanda 1490-Plat 8:45 am A PHARMACOLOGICAL MASTERKEY MECHANISM TO UNLOCK THE SELEC- TIVITY FILTER GATE IN K+ CHANNELS. Marcus Schewe , Han Sun, Alexandra Mackenzie, Ashley C. W. Pike, Friederike Schulz, Christina Constantin, Aytug K. Kiper, Linus J. Conrad, Wendy Gonzalez, Bert L. de Groot, Niels Decher, Bernd Fakler, Elisabeth P. Carpenter, Stephen J. Tucker, Thomas 9:00 am PH DEPENDENCE OF A MONOMERIC NON-CONDUCTING VOLTAGE- GATED PROTON CHANNEL (H V 1).  Emerson M. Carmona , Osvaldo Alvarez, Alan Neely, Ramon Latorre, Carlos Gonzalez 1492-Plat 9:15 am STRUCTURES REVEAL OPENING OF THE STORE-OPERATED CALCIUM CHANNEL ORAI.  Xiaowei Hou , Shana R. Burstein, Stephen B. Long 1493-Plat 9:30 am DEVELOPING SYNTHETIC PEPTIDES TO REGULATE NATIVE HCN CHAN- NELS.  Andrea Saponaro , Francesca Cantini, Alessandro Porro, Annalisa Bucchi, Dario DiFrancesco, Vincenzo Maione, Michal Laskowski, Pietro Mesirca, Matteo Mangoni, Gerhard Thiel, Lucia Banci, Bina Santoro, Anna Moroni 9:00 am Baukrowitz 1491-Plat

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