Biophysical Society 63rd Annual Meeting | Program Guide

hERG and LQT3 LATE NAV1.5) AND NAV1.7 DRUG DISCOVERY Successful ion channel drug discovery requires the integration of multiple technologies and workflows. Sophion Bioscience is a leader in automated patch clamp technology, providing medium to high throughput, auto- mated patch clamp to the pharmaceutical industry and universities. The QPatch and Qube are fully automated patch clamp systems, executing simultaneous 8, 16, 48 or 384 parallel patch clamp recordings in conjunc- tion with computer controlled liquid handling and on-board cell handling. Sophion partners with other biotech companies to create robust, ion channel and electrophysiological workflows for drug development for ion channel targets. During this workshop, three industry speakers will provide insight into the drug discovery process. Dr Kadla Roskva Rosholm will present how hiPSCderived neurological disease models have been characterized by use of high throughput electrophysiology at Sophion Bioscience. Next, Dr Marc Rogers fromMetrion Biosciences will present their development of new automated patch clamp ion channel assays for CiPA cardiac safety testing: dynamic hERG and LQT3 late Nav1.5. Finally, Dr Brian Moyer will present on Amgen’s Nav1.7 drug discovery program. Speakers Kadla Roskva Rosholm, Application Scientist, Sophion Bioscience A/S Marc Rogers, Chief Scientific Officer, Metrion Biosciences Brian Moyer, Scientific Director, Department of Neuroscience, Amgen Exhibits 10:00 am - 4:00 pm, Exhibit Hall Coffee Break 10:15 am - 11:00 am, Exhibit Hall Symposium Awards 10:45 am - 12:45 pm, Ballroom I Chair Angela Gronenborn, University of Pittsburgh and BPS President No Abstract 10:45 am MODELING THE DYNAMICS OF CDC42 OSCILLATION IN FISSION YEAST.  Bin Xu No Abstract 10:58 am TECHNOLOGY DEVELOPMENT TOWARDS THE UNDERSTANDING OF G-PROTEIN COUPLED RECEPTOR STRUCTURE FUNCTION.  Raymond C. Stevens No Abstract 11:11 am FINDING ORDER IN DISORDER: FUNCTIONAL STUDIES OF DYSFUNCTION- AL PROTEINS.  Elizabeth Rhoades No Abstract 11:24 am MANY SINGLE MOLECULES.  Jeff Gelles No Abstract 11:37 am FUNCTIONAL PROTEIN FIBRILS AS ANTIBACTERIAL AGENTS AND TAR- GETS. Meytal Landau No Abstract 11:50 am LAURDAN GP FOR THE QUANTITATION OF LIPID PHASES.  Enrico Gratton N o Abstract 12:03 pm SURFACE PROGRAMMING OF PROTEIN HYDRATION WATER DYNAMICS REVEALED BY OVERHAUSER DYNAMIC NUCLEAR POLARIZATION.  Song-I Han

1505-Plat 8:30 am SUPER-RESOLUTION IMAGING OF THE BRAIN EXTRACELLULAR SPACE DEEP WITHIN INTACT LIVE TISSUE USING CARBON NANOTUBES.  Antoine G. Godin , Noémie Danné, Juan A. Varela, Gao Zhenghong, Brahim Lounis, Laurent Groc, Laurent Cognet 1506-Plat 8:45 am ULTRA-FAST GLUTAMATE BIOSENSOR RECORDINGS IN BRAIN SLICE DISPLAY COMPLEX SINGLE EXOCYTOSIS TRANSIENTS.  Ann-Sofie U. Cans , Yuanmo Wang, Devesh Mishra, Jenny Bergman, Jacqueline Keighron, Karolina Skibicka 1507-Plat 9:00 am PIEZO2 UNDERLIES SLOWLY-INACTIVATING MECHANO-CURRENT IN SEN- SORY NEURONS FROM TACTILE SPECIALIST BIRDS.  Slav N. Bagriantsev , Eve R. Schneider, Evan O. Anderson 1508-Plat 9:15 am DYNAMIC REGULATION OF AMPA RECEPTOR AND STARGAZIN CONCEN- TRATION IN THE SPINE IN THE TIME SCALE OF 0.1 S TO SEVERAL 100 S; UNRAVELING BY SINGLE-MOLECULE TRACKING.  Yuri L. Nemoto , Kazuma Naito, Hiroko Hijikata, Taka A. Tsunoyama, Nao Hiramoto-Yamaki, Rinshi S. Kasai, Yuki M. Shirai, Manami S. Miyahara, Takahiro K. Fujiwara, Akihiro Kusumi 1509-Plat 9:30 am SINGLE-MOLECULE MECHANICS OF THE MOLECULAR SPRING THAT UN- DERLIES HEARING.  Tobias F. Bartsch , Felicitas E. Hengel, Aaron Oswald, Gilman Dionne, Iris V. Chipendo, Simranjit Mangat, Muhammad El Shat- anofy, Ulrich Mueller, Lawrence Shapiro, A. J. Hudspeth 1510-Plat 9:45 am TRAVEL AWARDEE THE NEURONAL TAU PROTEIN BLOCKS IN VITRO FIBRILLATION OF THE AMYLOID-Β (AΒ) PEPTIDE.  Cecilia Wallin , Yoshitaka Hiruma, Sebastian Warmlander, Isabelle Huvent, Jüri Jarvet, Jan Pieter Abrahams, Astrid Gräslund, Guy Lippens, Jinghui Luo 1511-Plat 10:00 am ACTIVATION OF SLACK POTASSIUM CHANNELS (KCNT1) TRIGGERS AN INCREASE IN MRNA TRANSLATION.  Taylor J. Malone , Pawel Licznerski, Elizabeth A. Jonas, Leonard K. Kaczmarek Subgroup Chairs Meeting 9:00 am - 10:30 am, Room 331 Career Development Center Workshop Looking Beyond Academia: Identifying Your Career Options using MyIDP, LinkedIn & More 9:30 am - 10:30 am, Exhibit Hall A Not sure where your professional future lies or how to approach the process in an organized and strategic manner? This presentation provides a framework and resources for moving forward with confidence towards the next step in your professional future. In addition, it will provide specific examples of how to build out your knowledge of a new potential career field and forge valuable connections that can facilitate a successful transition. Exhibitor Presentation Sophion Bioscience A/S 9:30 am - 11:00 am, Room 303 ELECTROPHYSIOLOGICAL CHARACTERIZATION USING AUTOMATED PATCH CLAMP (QPATCH AND QUBE) OF hiPSC-DERIVED NEUROLOGICAL DISEASE MODELS, NEW AUTOMATED PATCH CLAMP ION CHANNEL ASSAYS FOR CiPA CARDIAC SAFETY TESTING (DYNAMIC

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