Biophysical Society 65th Annual Meeting Program Guide

Tuesday, February 23

32-Plat 11:15 am STRUCTURAL AND FUNCTIONAL STUDIES OF THE EFFECTS OF PHOS- PHORYLATION ON EPHRIN RECEPTOR TYROSINE KINASE, EPHA2, AND THE RELATIONSHIP WITH ITS SAM DOMAIN AS AN AUTOINHIBITOR. Pravesh Shrestha , Zen-lu Li, Amita Rani Sahoo, Xiaojun Shi, Fatima Ra- zelle Javier, Deanna Bowman, Jeannine Mueller-Greven, Belinda Willard, Bing-Cheng Wang, AdamW. Smith, Matthias Buck Platform Protein Prediction, Design, and Stability I 10:00 am - 11:30 am Chair Rebecca Wade, Heidelberg Institute for Theoretical Studies, Germany 33-Plat 10:00 am PREDICTION OF THE STRUCTURE AND DYNAMICS OF PROTEIN COM- PLEXES IN MEMBRANES. Rebecca Wade 34-Plat 10:30 am NEAR-NATIVE ENTANGLED PROTEIN CONFORMATIONS ARE THE MO- LECULAR BRIDGE CONNECTING SYNONYMOUS MUTATIONS TO LONG- TIMESCALE CHANGES IN PROTEIN STRUCTURE AND FUNCTION. Edward P. O’Brien 35-Plat 10:45 am OBSERVING THE REGULATION OF THE HSP90 CHAPERONE BY CO-CHAP- ERONES AND NUCLEOTIDES. Katarzyna M. Tych , Markus Jahn, Hannah Girstmair, Thorsten Hugel, Johannes Buchner, Matthias Rief 36-Plat 11:00 am CONTRIBUTION OF NASCENT POLYPEPTIDES OF INCREASING LENGTH TO THE APPARENT STABILITY OF THE BACTERIAL RIBOSOME. Meranda Masse , Angela Varela, Aniruddha Srivastava, Wanting Wei, Silvia Cavag- nero 37-Plat 11:15 am FOLDING, FOLD SWITCHING AND ENERGY LANDSCAPE OF REGULATORY PROTEIN RFAH. Bahman Seifi, Adekunle Aina, Stefan Wallin Platform DNA Structure and Dynamics 10:00 am - 11:30 am Chair G.V. Shivashankar, ETH Zurich and Paul Scherrer Institute, Switzerland 38-Plat 10:00 am MECHANICAL CONTROL OF CHROMATIN ORGANIZATION AND CELL-FATE DECISIONS. G.V. Shivashankar 39-Plat 10:30 am PROBING THE CONTRIBUTIONS TO DNA HYBRIDIZATION DYNAMICS WITH TIME-RESOLVED INFRARED SPECTROSCOPY. Brennan Ashwood , Paul J. Sanstead, Qing Dai, Chuan He, Andrei Tokmakoff 40-Plat 10:45 am HOOGSTEEN BASE PAIRS INCREASE THE SUSCEPTIBILITY OF DOUBLE- STRANDED DNA TO CYTOTOXIC DAMAGE. Akanksha Manghrani , Yu Xu, Emily Cannistraci, HashimM. Al-Hashimi 41-Plat 11:00 am RAPID (SUB-20 µS) INTRINSIC DNA FLUCTUATIONS AT DAMAGED SITES IMPLICATED IN STALLING RAD4/XPC DNA REPAIR PROTEIN DURING DAM- AGE SENSING. Saroj Baral , Sagnik Chakraborty, Debamita Paul, Jung- Hyun Min, Anjum Ansari 42-Plat 11:15 am CHARACTERIZATION OF LOCUS SPECIFIC CHROMATIN STRUCTURE AND DYNAMICS USING CORRELATIVE CONVENTIONAL SUPER RESOLUTION CRISPR DCAS9/MS2 IMAGING. Dushyant Mehra , Chiranjib Banerjee, Santosh Adhikari, Jacob M. Ritz, Angel Mancebo, Elias M. Puchner

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General Networking 9:00 am-10:00 am

Catch up with colleagues and friends in the biophysical community during our networking hour. This event, which is open to all meeting attendees, provides meet-and-greet opportunities to enhance your virtual meeting experience. Symposium Future of Biophysics 10:00 am - 11:30 am Support Contributed By The Burroughs Wellcome Fund Co-chairs Patricia Bassereau, Institut Curie, France Bertrand Garcia-Moreno, Johns Hopkins University, USA No Abstract 10:00 am COMBINING PHYSICS-BASED AND KNOWLEDGE-BASED COMPUTATIONAL METHODS FOR THE STUDY OF MEMBRANE PROTEINS. Chen Song No Abstract 10:22 am DECIPHERING A SMART MATERIAL - A NEWMETHOD TO MEASURE ACTIN CORTEX MECHANICS AND MECHANOSENSITIVITY. Elisabeth Fischer-Friedrich No Abstract 10:44 am VIROLOGY UNDER THE BIOPHYSICAL LENS: FROM VIRAL MECHANISMS TO PREDICTING AND PREVENTING THE NEXT PANDEMIC. Tijana Ivanovic No Abstract 11:06 am THE DAWN OF IN-VIVO MOLECULAR DYNAMICS SIMULATIONS. Abhishek Singharoy Platform Protein Structure and Conformation: Interactions 10:00 am - 11:30 am Chair Rafael Brüschweiler, The Ohio State University, USA No Abstract 10:00 am NANOPARTICLE-ASSISTED NMR SPIN RELAXATION FOR STUDYING THE DYNAMICS AND INTERACTIONS OF FOLDED AND INTRINSICALLY DISOR- DERED PROTEINS. Rafael Bruschweiler 29-Plat 10:30 am INVESTIGATING THE STRUCTURE AND FUNCTION OF COACTIVATOR RE- CRUITMENT BY THE MELANOGENIC TRANSCRIPTION FACTOR MITF. Alexandra D. Brown , Kathleen Vergunst, Denis J. Dupré, David N. Lange- laan 30-Plat 10:45 am CRYO-EM STRUCTURE OF CGAS-NUCLEOSOME COMPLEX REVEALS MECHANISM OF NUCLEOSOME-DEPENDENT CGAS INHIBITION. Cathy J. Spangler , Joshua A. Boyer, Joshua D. Strauss, Andrew P. Cesmat, Pengda Liu, Robert K. McGinty, Qi Zhang 31-Plat 11:00 am CRYSTAL STRUCTURE REVEALS THE FULL RAS: RAF INTERFACE AND ADVANCES MECHANISTIC UNDERSTANDING OF RAF ACTIVATION. Trinity Cookis , Carla Mattos

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