Biophysical Society 65th Annual Meeting Program Guide

Platform Membrane Protein Structures 2:00 pm - 3:30 pm

Platform Protein-Nucleic Acid Interactions and Chromatin I 2:00 pm - 3:30 pm

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Chair José Faraldo-Gómez, NIH, NHLBI, USA No Abstract 2:00 pm LIPID BILAYER MORPHOLOGY AS A DRIVING FORCE FOR MEMBRANE PROTEIN ORGANIZATION. José Faraldo-Gómez 441-Plat 2:30 pm OLIGOMERIZATION OF THE HUMAN ADENOSINE A 2A RECEPTOR IS DRIVEN BY THE INTRINSICALLY DISORDERED C-TERMINUS. Khanh D. Nguyen , Mi- chael Vigers, Eric Sefah, Susanna Seppala, Jennifer Hoover, Blake Mertz, Michelle A. O’Malley, Songi Han 442-Plat 2:45 pm VIRUS-HOST PROTEIN INTERACTIONS IN THE DEGRADATION PATHWAY OF HUMAN SERINC5 BY NEF. Joana Paulino , Alisa Bowen, Phuong Nguyen, Lucas Liu, Janet Finer-Moore, Robert M. Stroud 443-Plat 3:00 pm BAMB STABILIZES BAMA’S LATERALLY OPEN AND CLOSED STATES. David Ryoo , Katie M. Kuo, Zijian Zhang, Yui Tik Pang, James C. Gumbart 444-Plat 3 :15 pm TOWARDS MECHANISTIC UNDERSTANDING OF MITOCHONDRIAL Β-BARREL BIOGENESIS: STRUCTURAL STUDIES OF THE SORTING AND ASSEMBLY MACHINERY. Kathryn A. Diederichs , Xiaodan Ni, Sarah E. Rol- lauer, Istvan Botos, Xiaofeng Tan, Martin S. King, Edmund Kunji, Jiansen Jiang, Joseph A. Mindell, Susan K. Buchanan Platform Intrinsically Disordered Proteins (IDP) and Aggregates I 2:00 pm - 3:30 pm Chair Yuri Lyubchenko, University of Nebraska Medical Center, USA 445-Plat 2:00 pm MISFOLDING AND AGGREGATION OF AMYLOID PROTEINS AT PHYSI- OLOGICALLY RELEVANT CONCENTRATIONS AT THE LIQUID-MEMBRANE INTERFACE. Yuri L. Lyubchenko , Mohtadin Hashemi, Siddhartha Banerjee 446-Plat 2:30 pm AMPHIPHILIC PROTEINS COAT MEMBRANELESS ORGANELLES AND ACT AS BIOLOGICAL SURFACTANTS. Fleurie Kelley , Benjamin S. Schuster 447-Plat 2:45 pm PHYSICAL THEORY OF CONCENTRATION BUFFERING IN MULTI-COMPO- NENT, PHASE-SEPARATING SYSTEMS. Dan Deviri , Samuel Safran 448-Plat 3:00 pm HIDDEN COMPLEXITIES IN THE PHASE BEHAVIOR OF LOW-COMPLEXITY DISORDERED PROTEINS. Anne Bremer , Mina Farag, Wade M. Borcherds, Rohit V. Pappu, Tanja Mittag 449-Plat 3:15 pm PROBING THE HIDDEN SENSITIVITY OF INTRINSICALLY DISORDERED PROTEINS TO THEIR CHEMICAL ENVIRONMENT. David Moses , Karina Guadalupe, Shahar Sukenik

Chair Karolin Luger, University of Colorado, Boulder, USA No Abstract 2:00 pm UNFINISHED BUSINESS: NUCLEOSOMES IN TRANSITION. Karolin Luger 450-Plat 2:30 pm FORCE-DEPENDENT STIMULATION OF RNA UNWINDING BY SARS-COV-2 NSP13 HELICASE. Keith J. Mickolajczyk , Patrick M. Shelton, Michael Grasso, Xiaocong Cao, Sara E. Warrington, Amol Aher, Shixin Liu, Tarun M. Kapoor 451-Plat 2:45 pm INVESTIGATING HOW THE RESTRICTION ENDONUCLEASE BCNI FLIPS ON DNA. Nirmala Shrestha, Kyle Russell, Nooshin Shatery Nejad, Candice M. Etson 452-Plat 3:00 pm UNCOVERING THE PHYSICAL BASIS FOR SELECTIVE MIXING VERSUS UNMIXING OF PROTEIN-RNA CONDENSATES. Andrew Z. Lin, Ammon E. Posey , Furqan Dar, Amy S. Gladfelter, Rohit V. Pappu 453-Plat 3:15 pm DISSECTING THE TARGET RECOGNITION BY CRISPR/CAS EFFECTOR COM- PLEXES WITH ULTRAFAST TWIST MEASUREMENTS. Julene Madariaga Marcos , Dominik J. Kauert, Marius Rutkauskas, Alexander Wulfken, Inga Songaliene, Tomas Sinkunas, Virginijus Siksnys, Ralf Seidel Platform Membrane Receptors and Signal Transduction 2:00 pm - 3:30 pm Chair Scott Hansen, University of Oregon, USA No Abstract 2:00 pm PHOSPHATIDYLINOSITOL LIPID MODIFYING ENZYMES IN CELL SIGNALING. Scott Hansen 454-Plat 2:30 pm IDENTIFICATION OF LIGAND-SPECIFIC G-PROTEIN COUPLED RECEPTOR STATES AND PREDICTION OF DOWNSTREAM EFFICACY VIA DATA-DRIVEN MODELING. Oliver Fleetwood, Lucie Delemotte 455-Plat 2:45 pm EFFECTS OF SOFT MATTER ON G-PROTEIN-COUPLED RECEPTOR ACTIVA- TION. Kushani S.K. Hewage , Shifat Hossain, Steven D.E. Fried, Helen F. Mann, Benjamin H.C. Cabrera, Zizhao Yu, David B. Jurkowitz, Andrey V. Struts, Suchithranga M.D.C. Perera, Michael F. Brown 456-Plat 3:00 pm A SINGLE-MOLECULE APPROACH TO STUDY B CELL ANTIGEN RECOGNI- TION AND AFFINITY DISCRIMINATION. Anna T. Bajur , Hannah Reed, Maro Iliopoulou, Katelyn M. Spillane 457-Plat 3:15 pm PLASMA MEMBRANE ORGANIZATION IS POISED FOR RECEPTOR-MEDI- ATED TRANSMEMBRANE SIGNALING. Nirmalya Bag , David A. Holowka, Barbara A. Baird

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