Biophysical Society 65th Annual Meeting Program Guide

Platform Membrane Traffic 2:00 pm - 3:30 pm

Platform Molecular Dynamics and Bioinformatics I 2:00 pm - 3:30 pm Chair Qiang Cui, Boston University, USA No Abstract 2:00 pm ELECTROSTATICS IN ATOMISTIC AND COARSE-GRAINED MOLECULAR SIMULATIONS: FROM BURIED ION-PAIRS TO MEMBRANE REMODELING. 2:30 pm KINETICS AND FREE ENERGY OF PROTEIN LIGAND INTERACTION USING WEIGHTED ENSEMBLE MILESTONING (WEM). Dhiman Ray , Trevor Gokey, David L. Mobley, Ioan Andricioaei 468-Plat 2:45 pm PEPTIDE GAUSSIAN ACCELERATED MOLECULAR DYNAMICS (PEP-GAMD) ENHANCED SAMPLING AND FREE ENERGY AND KINETICS CALCULATIONS OF PEPTIDE BINDING. Jinan Wang , Yinglong Miao 469-Plat 3:00 pm LIGAND GAUSSIAN ACCELERATED MOLECULAR DYNAMICS (LIGAMD) FOR CHARACTERIZATION OF LIGAND BINDING THERMODYNAMICS AND KINETICS. Yinglong Miao , Apurba Bhattarai, Jinan Wang 470-Plat 3:15 pm FREE ENERGY ALONG TRANSITION PATHWAYS FROM STRUCTURE REFINE- MENT SIMULATIONS. Emmi Pohjolainen , Andrea C. Vaiana, Maxim Igaev, Helmut Grubmuller Platform Biosensors and Nanotechnology 2:00 pm - 3:30 pm Chair Hendrik Dietz, Technische Universität München, Germany No Abstract 2:00 pm PROGRAMMABLE ICOSAHEDRAL SHELL SYSTEM FOR VIRUS TRAPPING. Hendrik Dietz 471-Plat 2:30 pm DECODING DIGITAL INFORMATION STORED IN POLYMER BY NANOPORE. Chan Cao , Lucien Krapp, Abdelaziz Ouahabi, Aleksandra Radenovic, Jean- François Lutz, Matteo Dal Peraro 472-Plat 2:45 pm NOVEL SYNTHETIC NANOPORES FOR SINGLE-MOLECULE BIOSENSING APPLICATIONS. Mehrnaz Mojtabavi , Meni Wanunu 473-Plat 3:00 pm SINGLE-MOLECULE FRET BASED INTRA-MOLECULAR KINETIC FINGER- PRINTING FOR ULTRAFAST AND HIGH-CONFIDENCE COUNTING OF MU- TANT DNA. Shankar Mandal , Kunal Khanna, Muneesh Tewari, Alexander Johnson-Buck, Nils G. Walter 474-Plat 3:15 pm DIRECT AND ACCURATE DETECTION OF DNA METHYLATION POSITIONS USING BIOLOGICAL NANOPORE. Ping Liu Qiang Cui 467-Plat

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Chair Sandra Schmid, University of Texas, Southwestern Medical Center, USA No Abstract 2:00 pm THE PLASTICITY AND ROBUSTNESS OF CLATHRIN-MEDIATED ENDOCYTO- SIS. Sandra Schmid 458-Plat 2:30 pm MECHANISMS OF ACTIN FORCE PRODUCTION IN CLATHRIN-MEDIATED ENDOCYTOSIS REVEALED BY INTEGRATING MATHEMATICAL MODELING WITH IN SITU CRYO-ELECTRON TOMOGRAPHY. Matthew Akamatsu , Daniel Serwas, Amir Moyaed, Ritvik Vasan, Karthik Vegesna, Jennifer Hill, Johannes Schoeneberg, Padmini Rangamani, David G. Drubin 459-Plat 2:45 pm STRESSES WITHIN THE ENDOCYTIC ACTIN MESHWORK CONTROLS THE TURNOVER OF FIMBRIN. Xiaobai Li , Julien Berro 460-Plat 3:00 pm MECHANOREGULATION OF EXOCYTOSIS RATES BY VESICLE-MEMBRANE MERGING KINETICS. Rui Su , Ben O’Shaughnessy 461-Plat 3:15 pm SUBCELLULAR MAGNETIC CONTROL OF PHAGOSOME MATURATION IN LIVING CELLS. Zihan Zhang , Yanqi Yu, Glenn Walpole, Yan Yu Platform Muscles I 2:00 pm - 3:30 pm Chair Zhen Ma, Syracuse Biomaterials Institute, USA 462-Plat 2:00 pm CONTRACTILE DEFICITS OF HIPSC-DERIVED CARDIAC MICROTISSUES INDUCED BY SYNERGISTIC OUTCOME OF MYBPC3 MUTATION AND ME- CHANICAL OVERLOADING. Zhen Ma 463-Plat 2:30 pm STEP SIZE AND KINETICS OF CARDIAC MYOSIN CROSSBRIDGES ARE NOT AFFECTED BY TROPONIN AND TROPOMYOSIN. Sarah R. Clippinger , Wil- liam Stump, Thomas Blackwell, Michael J. Greenberg 464-Plat 2:45 pm THE ROLE OF SEPTIN7 IN SKELETAL MUSCLE REGENERATION. Mónika Gönczi, János Fodor, Andrea Telek, Nóra Dobrosi, Zsolt Ráduly, László Szabó, Peter Szentesi, Beatrix Dienes, Laszlo Csernoch 465-Plat 3:00 pm STRUCTURAL CHANGES IN THE MYOSIN FILAMENT INDUCED BY COOL- ING ISOLATED CARDIAC TRABECULAE. Jesus G. Ovejero, Luca Fusi, So-Jin Park-Holohan, Andrea Ghisleni, Theyencheri Narayanan, Malcolm Irving, Elisabetta Brunello 466-Plat 3:15 pm FIBERSIM, AN OPEN-SOURCE SPATIALLY-EXPLICIT MODEL OF THE HALF- SARCOMERE. Sarah Kosta, Dylan F. Colli, Kenneth S. Campbell

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