Biophysical Society 65th Annual Meeting Program Guide

253-Pos B oard B187 PLC E ACTIVITY IS ESSENTIAL FOR PACAP-STIMULATED SECRETION FROM CHROMAFFIN CELLS. Alina Chapman-Morales , Shreeya Bakshi, Ramku- mar Mohan, Mounir Bendahmane, Alan Smrcka, Arun Anantharam Calcium Signaling (Boards B188 - B199) 254-Pos B oard B188 IPSCS-BASED MODELS OF POLYGLUTAMINE SPINOCEREBELLAR ATAXIAS OF TYPE 1 AND 17 HAVE DIFFERENT IMPAIRMENTS OF CALCIUM SIG- NALING. Dmitry Grekhnyov , Vladimir Vigont, Elena Kaznacheyeva 255-Pos B oard B189 QUANTIFICATION OF INSULIN VESICLE DYNAMICS, FUSION EVENTS AND CALCIUM ACTIVITY IN INTACT MOUSE ISLETS. Xue Wen Ng , Michael R. DiGruccio, David W. Piston 256-Pos B oard B190 LOCAL SYNTHESIS OF SARCOLEMMA AND SARCOPLASMIC RETICULUM MEMBRANE PROTEINS IN CARDIAC MYOCYTES. Vladimir Bogdanov , AndrewM. Soltisz, Marina Ivanova, Ivan Andreev, Galina Sakuta, Jona- than P. Davis, Rengasayee Veeraraghavan, Sandor Gyorke 257-Pos B oard B191 A NOVEL METHOD FOR SINGLE MOLECULE VISUALIZATION OF ACTIVE PROTEIN SYNTHESIS IN CARDIAC MYOCYTES REVEALS SERCA2A MRNA TRANSLATION IS SARCOPLASMIC RETICULUM CA 2+ LOAD DEPEN - DENT. Vladimir Bogdanov , AndrewM. Soltisz, Marina S. Ivanova, Ivan S. Andreev, Rengasayee Veeraraghavan, Jonathan P. Davis, Sandor Gyorke 258-Pos B oard B192 THE ROLE OF S-ACYLATION IN THE REGULATION OF STORE-OPERATED CALCIUM ENTRY. Savannah J. West , Qiaochu Wang, Goutham Kodakan- dla, Michael X. Zhu, Darren Boehning, Askar M. Akimzhanov 259-Pos B oard B193 TOBACCO HORNWORM ( MANDUCA SEXTA ) CATERPILLAR HEMOLYMPH MODULATES REACTIVE OXYGEN SPECIES AND CALCIUM GENERATION IN TOMATO PROTOPLASTS. Akanksha Gandhi, Rupesh Kariyat, Nirakar Sahoo 260-Pos B oard B194 A MODELING FRAMEWORK FOR INVESTIGATING THE ROLE OF HUMAN ATRIAL FIBROBLAST CALCIUM SIGNALING IN FIBROGENESIS. Alex Fogli Iseppe , Stefano Morotti, Marcel Tekook, Dennis Hoffmann, Andrew G. Edwards, Dobromir Dobrev, Eleonora Grandi 261-Pos B oard B195 JUPITER MICROTUBULE ASSOCIATED HOMOLOG 2 IS A NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE (NAADP) BINDING PROTEIN RE- QUIRED FOR NAADP-EVOKED INTRACELLULAR CALCIUM RELEASE. Gihan S. Gunaratne , Eugen Brailoiu, Shijun He, Sandip Patel, James T. Slama, Timothy Walseth, Jonathan S. Marchant 262-Pos B oard B196 IDENTIFICATION OF A STIM1 SPLICING VARIANT THAT PROMOTES TUMOR GROWTH. Guolin Ma , Lian He, Yubin Zhou 263-Pos B oard B197 GADOLINIUM DIFFERENTIALLY AFFECTS MEMBRANE PERMEABILIZA- TION AND CA 2+ INFLUX INDUCED BY NANOSECOND ELECTRIC PULSES IN BOVINE ADRENAL CHROMAFFIN CELLS. Lisha Yang , Sophia Pierce, Gale L. Craviso, Normand Leblanc 264-Pos B oard B198 DUAL IMPACT OF HEART RATE VARIABILITY AND SUBCELLULAR CAL- CIUM HETEROGENEITY ON CARDIAC ALTERNANS. Vrishti Phadumdeo , Seth H. Weinberg

265-Pos B oard B199 EXPLORING THE EFFECTS OF MUTATIONS AND THICK FILAMENT PRO- TEINS ON MYOFILAMENT CALCIUM KINETICS VIA STOPPED-FLOW. MatthewM. Klass , Rhye-Samuel Kanassatega, Sarah Lehman, Jil C. Tar- diff, Brett A. Colson, Jonathan P. Davis Ligand-gated Channels I (Boards B200 - B218) 266-Pos B oard B200 HERITABLE MUTATIONS TO THE Β3 SUBUNIT OF GABA-A RECEPTOR ALTER THE RECEPTOR FUNCTION AND SYNAPTIC LOCALISATION. Nela I. Durisic , Joseph W. Lynch, Ned Cotter, Dejan Gagoski, Parnayan Syed, Pankaj Sah, Duka Skalamera 267-Pos B oard B201 TWO-PHOTON PHOTOACTIVATION OF RUBI-GABA FOR STUDYING THE ROLE OF THE ANTISECRETORY FACTOR IN THE MODULATION OF THE GABA A RECEPTOR IN RAT CEREBELLAR GRANULE CELLS IN VITRO . Virginia Bazzurro , Elena Gatta, Elena Angeli, Aroldo Cupello, Stefan Lange, Mauro Robello, Alberto Diaspro 268-Pos B oard B202 INFLUENCE OF GABA-A RECEPTOR INTRACELLULAR DOMAIN ON CHAN- NEL ACTIVATION AND DESENSITIZATION. Anton J. Tung , Lucas M. Blecker, Cynthia Czajkowski 269-Pos B oard B203 A CONSERVED ARGININE WITH NON-CONSERVED FUNCTION IS A KEY DETERMINANT OF AGONIST SELECTIVITY IN ALPHA7 NICOTINIC ACE- TYLCHOLINE RECEPTORS. Teresa Minguez Vinas , A. Sofia F. Oliveira, B. Elizabeth Nielsen, Cecilia Gotti, Adrian J. Mulholland, Timothy Gallagher, Isabel Bermudez 270-Pos B oard B204 STRUCTURAL INVESTIGATION INTO GATING AND MODULATION OF ALPHA1 GLYCINE RECEPTOR IN LIPID NANODISCS. Arvind Kumar , Sandip Basak, Shanlin Rao, Mark S. Sansom, Sudha Chakrapani 271-Pos B oard B205 WHEN A GAIN BECOMES A LOSS: GAIN-OF-FUNCTION GLYCINE RECEP- TORS AND HYPEREKPLEXIA. James P. Dilger , Mohammed A. Shanawaz 272-Pos B oard B206 CONFORMATIONAL LANDSCAPE OF AN AGONIST-BINDING DOMAIN OF A FULL-LENGTH HETEROMERIC KAINATE RECEPTOR GLUK2/K5 DISPLAY- ING PARTIAL AGONISM. Nabina Paudyal , Elisa Carrillo, Vladmir Berka, Vasanthi Jayaraman 273-Pos B oard B207 FATTY ACIDS INHIBIT A PENTAMERIC LIGAND-GATED ION CHANNEL THROUGH ONE OF TWO BINDING SITES. Noah Dietzen, John T. Petroff, Douglas F. Covey, Wayland W. Cheng 274-Pos B oard B208 SOLUTION STRUCTURE OF THE GLOEOBACTER VIOLACEUS LIGAND-GAT- ED ION CHANNEL PROBED BY SMALL-ANGLE NEUTRON SCATTERING. Marie Lycksell , Urska Rovsnik, Cathrine C. Bergh, Nicolai T. Johansen, Anne Martel, Lionel Porcar, Lise Arleth, Rebecca J. Howard, Erik Lindahl 275-Pos B oard B209 AGONIST EFFICIENCY ESTIMATED FROM CONCENTRATION RESPONSE CURVE. Dinesh Indurthi , Anthony Auerbach 276-Pos B oard B210 INVESTIGATION OF CATION PERMEATION THROUGH AMPA RECEPTORS BY MOLECULAR DYNAMICS SIMULATIONS. Johann Biedermann , Andrew J. Plested, Han Sun, Sebastian Braunbeck

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