Biophysical Society 65th Annual Meeting Program Guide

Skeletal and Smooth Muscle Mechanics, Structure, and Regulation (Boards B225 - B240) 291-Pos B oard B225 COLLECTIVE FORCE GENERATOR MODEL OF MUSCLE CONTRAC- TION. Vidya Murthy , Travis J. Stewart, Josh E. Baker 292-Pos B oard B226 SATURATION OF ACTIN-MYOSIN KINETICS AND MECHANICS. Josh E. Baker 293-Pos B oard B227 MECHANICAL FORCE RATHER THAN STRONG BINDING INTERMEDIATES EXTENDS ACTIVATION OF REGULATED ACTIN. Henry G. Zot , Prescott B. Chase, Javier E. Hasbun, J. Renato D. Pinto 294-Pos B oard B228 TIRASEMTIV AND DATP SYNERGISTICALLY REVERSE THE ACIDOSIS- INDUCED DEPRESSION OF MYOSIN’S FORCE AND MOTION GENERATING CAPACITY. Christopher P. Marang , Brent D. Scott, Mike K. Woodward, Edward P. Debold 295-Pos B oard B229 CONTRACTILITY DEFICIENCY OF TPNT-CD70 FLY MUSCLES UNDERLYING THE HOMOZYGOUS LETHALITY. Gabriela Aires Moragas 296-Pos B oard B230 THE ATOMIC MODEL FOR MYOSIN II COILED-COIL SHOWS NOVEL OBSER- VATIONS AND INSIGHTS INTO MUSCLE CONTRACTION. Hamidreza Rahmani , Nadia Daneshparvar, Dianne W. Taylor, Wen Ma, Kenneth A. Taylor 297-Pos B oard B231 TWO ATP ENERGY-SAVING MECHANISMS IN RELAXED TARANTULA SKELETAL MUSCLE. Raul Padron , Weikang Ma, Sebastian Duno-Miranda, Thomas C. Irving, Roger W. Craig 298-Pos B oard B232 DYNAMICS OF STRUCTURAL CHANGES IN MYOSIN-CONTAINING FILA- MENTS OF INTACT MOUSE EDL DURING TWITCH AND TETANIC CONTRAC- TIONS. Cameron Hill , Elisabetta Brunello, Luca Fusi, Jesus G. Ovejero, Malcolm Irving 299-Pos B oard B233 GRADED TITIN CLEAVAGE UNCOVERS THE PROTEIN’S ROLE FOR SAR- COMERE STRUCTURE AND FORCE GENERATION OF CONTRACTING MUSCLE. Anthony L. Hessel , Yong Li, Andreas Unger, David Ing, Franziska Koser, Jannik Recker, Johanna K. Freundt, Wolfgang A. Linke 300-Pos B oard B234 SARCOMERIC PROTEIN FATZ FORMS A TIGHT FUZZY COMPLEX WITH Α-ACTININ AND PHASE-SEPARATES IN VITRO. Antonio Sponga, Joan L. Arolas, Thomas C. Schwarz, Cy M. Jeffries, Julius Kostan, Anton A. Poly- ansky, Bojan Zagrovic, Dmitri Svergun, Bettina Warscheid, Robert Konrat, Mathias Gautel, Kristina Djinovic-Carugo 301-Pos B oard B235 THE COMPLIANCE-INDUCED SLOWDOWN OF STRESS RELAXATION IN AC- TIVE SARCOMERES. Khoi D. Nguyen , Madhusudhan Venkadesan 302-Pos B oard B236 STRETCH-ACTIVATION IN DROSOPHILA JUMP MUSCLE FIBERS IS DE- SCRIBED BY A MINIMAL CROSS-BRIDGE MODEL THAT INCLUDES FORCE- DEPENDENT WEAKLY-BOUND CROSS-BRIDGES AND SERIES ELASTIC- ITY. Katelyn Jarvis , Kaylyn Bell, Amy K. Loya, Douglas M. Swank, Sam Walcott

277-Pos B oard B211 INHIBITION OF AMPA RECEPTORS BY ZN 2+ . Elisa Carrillo , Nidhi Kaur Bha- tia, Askar M. Akimzhanov, Vasanthi Jayaraman 278-Pos B oard B212 STOICHIOMETRY OF GLUA1/GLUA2 HETEROMER OF AMPA RECEP- TOR. Antara Mukhopadhyay , Chenlu Yu, Maximilian H. Ulbrich 279-Pos B oard B213 A STATE-SPECIFIC INTERACTION STABILIZES NMDA RECEPTOR OPEN- ING. Gary J. Iacobucci , Han Wen, Matthew Helou, Beiying Liu, Wenjun Zheng, Gabriela K. Popescu 280-Pos B oard B214 SINGLE MOLECULE FRET INVESTIGATIONS OF THE NMDA RECEP- TOR. Ryan J. Durham , Nabina Paudyal, Elisa Carrillo, Nidhi Kaur Bhatia, David M. MacLean, Vladimir Berka, DrewM. Dolino, Alemayehu A. Gorfe, Vasanthi Jayaraman 281-Pos B oard B215 DIRECT M3-M4 INTERACTIONS CONTROL NMDA RECEPTOR GATING AND DESENSITIZATION. Hannah Premo , Beiying Liu, Gary J. Iacobucci, Gabriela K. Popescu 282-Pos B oard B216 PROBING ALLOSTERIC NETWORKS IN LIGAND-GATED ION CHANNEL GATING BY ELECTROPHYSIOLOGY AND MOLECULAR DYNAMICS IN THE MODEL RECEPTOR GLIC. Rebecca J. Howard , Yuxuan Zhuang, Sabina Gutheim, Luise Zeckey, Stephanie A. Heusser, Erik R. Lindahl 283-Pos B oard B217 THE ROLE OF THE OUTER LIPID-FACING HELIX IN CATIONIC PLGICS IS DEPENDENT ON THE CELLULAR CONTEXT. Susanne M. Mesoy , Sarah C.R. B oard B218 CONFORMATIONAL LANDSCAPES OF LIGAND-GATED ION CHANNEL GLIC FROMMARKOV STATE MODELING. Cathrine Bergh , Stephanie A. Heusser, Rebecca J. Howard, Erik R. Lindahl Other Channels (Boards B219 - B224) 285-Pos B oard B219 CENTRAL ROLE OF THE LOWEST PART OF S4 OF CI-VSP IN COUPLING MECHANISM. Natsuki Mizutani , Akira Kawanabe, Yasushi Okamura 286-Pos B oard B220 EVOLUTION OF INVERTED REPEATS IN MEMBRANE TRANSPORT- ERS. Christian B. Macdonald , Troy Cao, Randy Stockbridge 287-Pos B oard B221 EXPLORING THE PROTON-TRANSFER MECHANISM IN HV1 BY MULTI- SCALE SIMULATIONS. William B. Stone , AdamW. Duster, Ashley L. Ben- nett, I. Scott Ramsey, Hai Lin 288-Pos B oard B222 ALPHA-HEMOLYSIN CHANNEL INTERACTION WITH NEUTRAL POLY- MERS. Vicente M. Aguilella , Marcel Aguilella-Arzo 289-Pos B oard B223 PERMUTATION OF THE AMINO ACID AT THE CYTOSOLIC ENTRY TO THE CAVITY ALTERS CONDUCTANCE AND GATING OF K + CHANNEL IN AN AMINO SPECIFIC MANNER. Kerri Kukovetz , Matea Cartolano, Jonas Stein, Oliver Rauh, Alessandro Porro, Anna Moroni, Gerhard Thiel 290-Pos B oard B224 INFLUENCE OF HYDROPHOBICITY ON ANION SELECTIVITY. Linda X. Phan , Charlotte I. Lynch, Jason Crain, Stephen J. Tucker, Mark S. Sansom Lummis 284-Pos

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