Biophysical Society 65th Annual Meeting Program Guide

Platform Intrinsically Disordered Proteins (IDP) and Aggregates II 12:00 pm - 1:30 pm

Platform Protein-Lipid Interactions I 12:00 pm - 1:30 pm

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Chair Aurélien Roux, University of Geneva, Switzerland No Abstract 12:00 pm MECHANICS OF ESCRT-III MEMBRANE REMODELLING. Aurélien Roux 527-Plat 12:30 pm A WEB-BASED FRAMEWORK FOR THE AUTOMATED DATA ANALYSIS AND VISUALIZATION OF LIPID-PROTEIN INTERACTIONS. Besian I. Sejdiu , Peter D. Tieleman 528-Plat 12:45 pm ELUCIDATING THE MECHANISM OF MEMBRANE DESTABILIZATION BY THE PREFERRED MODES OF INSERTION OF THE SARS-COV2 FUSION PEPTIDE. George Khelashvili , Harel Weinstein 529-Plat 1:00 pm MEMBRANE SURFACE RECOGNITION BY THE ASAP1 PH DOMAIN AND CONSEQUENCES FOR INTERACTIONS WITH THE SMALL GTPASE ARF1. Olivier Soubias , Shashank Pant, Frank Heinrich, Yue Zhang, Paul Randaz- zo, Mathias Loesche, Emad Tajkhorshid, Robert A. Byrd 530-Plat 1:15 pm STRUCTURE AND FUNCTION OF VIROPORINS IN LIPID MEMBRANES: INSIGHTS FROM STUDIES BY EPR SPECTROSCOPY. Peter P. Borbat, Saman Majeed, Jack H. Freed, Elka R. Georgieva Platform Muscle, Calcium and Signaling I 12:00 pm - 1:30 pm Chair Claudia Moreno, University of Washington, USA No Abstract 12:00 pm EFFECTS OF AGING ON THE FUNCTION AND MODULATION OF L-TYPE CALCIUM CHANNELS IN THE CARDIAC PACEMAKER. Claudia Moreno 531-Plat 12:30 pm CA2+ HANDLING IN NON-FAILING HYPERTROPHIC CARDIOMYOCYTES SUBJECTED TO INOTROPIC INTERVENTIONS. Anna Krstic , Marie-Louise Ward 532-Plat 12:45 pm HIGH FREQUENCY ACOUSTIC CELL STIMULATION PROMOTES EXOSOME GENERATION REGULATED BY A CALCIUM- DEPENDENT MECHANISM. Lizebona August Ambattu , Shwathy Ramesan, Chaitali Dekiwadia, Eric Hanssen, Haiyan Li, Leslie Yeo 533-Plat 1:00 pm THE MALIGNANT HYPERTHERMIA G2435R MUTATION CAUSES CONSTITU- TIVE RYR1 OPENINGS. Thomas M. Humberstone , Chris Lindsay, Abigail D. Wilson, Elisa Venturi, Ahmed Alhussni, Charalampos Sigalas, Paul D. Allen, Rebecca M. Sitsapesan 534-Plat 1:15 pm TRPP1 CHANNEL CALCIUM SIGNALING AS A KEY DETERMINANT OF MYO- GENESIS. Sara Osorio Valencia , Virdjinija Vuchkovska, Elisabeth DiNello, Ivana Y. Kuo

Chair David Drummond, University of Chicago, USA No Abstract 12:00 pm RETHINKING STRESS-TRIGGERED PROTEIN AGGREGATION. David Drummond 518-Plat 12:30 pm A GENERAL FRET-BASED METHOD TO MONITOR PROTEIN OLIGOMER- IZATION AND CONDENSATE PHASE TRANSITION IN CELLS. Qi Wan , Sara Mavrova, Liesbeth Veenhoff, Arnold J. Boersma 519-Plat 12:45 pm CHARACTERIZATION OF THE STRUCTURAL FEATURES THAT MEDIATE PHASE SEPARATION OF INTRINSICALLY DISORDERED LOW-COMPLEXITY DOMAINS. Ivan Peran , Youlin Xia, Tanja Mittag 520-Plat 1:00 pm REAL-TIME MONITORING CONFORMATIONAL CHANGES OF A INTRINSI- CALLY DISORDERED PROTEIN WITH AEROLYSIN NANOPORE. Hongyan Niu , Xue-yuan Wu, Yi-Lun Ying, Yi-Tao Long 521-Plat 1:15 pm LIQUID-LIQUID PHASE SEPARATION OF REPEAT DISORDER SEQUENCES LEADS TO RNA CONFORMATIONAL AND DYNAMICAL HETEROGENEITY. Hung T. Nguyen , Dave Thirumalai Platform Nucleic Acid Replication, Transcription, Translation and Repair 12:00 pm - 1:30 pm Chair Alexandra Zidovska, New York University, USA 522-Plat 12:00 pm THE “SELF-STIRRED” GENOME: DYNAMICS, FLOWS AND RHEOLOGY. Alexandra Zidovska 523-Plat 12:30 pm STRUCTURAL AND DYNAMICAL SIGNATURES OF LOCAL DNA DAMAGE IN LIVE CELLS. Jonah A. Eaton , Alexandra Zidovska 524-Plat 12:45 pm STOCHASTIC SPATIAL SIMULATION OF GENETIC INFORMATION PROCESS- ES IN THE MINIMAL CELL. Zane R. Thornburg , Benjamin R. Gilbert, Julio Maia, John E. Stone, Vinson Lam, Elizabeth Villa, Zaida Luthey-Schulten 525-Plat 1:00 pm SINGLE-MOLECULE FRET ANALYSIS OF KEY PROTEIN CONFORMATIONAL CHANGES DURING PROMOTER ESCAPE BY RNA POLYMERASE. Anna Wang , Abhishek Mazumder, Achillefs N. Kapanidis 526-Plat 1:15 pm THE ROLE TRNA-MEDIATED REGULATION OF RIBOSOME DYNAMICS PLAYS IN FRAMESHIFTING BY +1 FRAMESHIFT-INDUCING TRNAS. Haixing Li , Howard Gamper, Ya-Ming Hou, Ruben L. Gonzalez

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