Biophysical Society 65th Annual Meeting Program Guide

Protein Stability, Folding, and Chaperones (Boards B1 - B27) 951-Pos B oard B1 THE MOLECULAR ORIGINS OF THE INFLUENCE OF TRANSLATION-ELON- GATION KINETICS ON THE SPECIFIC ACTIVITY OF ENZYMES. Yang Jiang , Edward P. O’Brien 952-Pos B oard B2 STRUCTURAL BASIS FOR RECOGNITION OF THE HSP90 CLOSED, ATP STATE BY THE TPR-CONTAINING CO-CHAPERONE FKBP51. Kanghyun Lee , Aye Thwin, Daniel R. Southworth 953-Pos B oard B3 MAPPING STRUCTURAL INTERMEDIATES DURING CO-TRANSLATIONAL FOLDING OF HSP70 WITH CROSSLINKING MASS SPECTROMETRY. Anneliese M. Faustino , Stephen D. Fried 954-Pos B oard B4 INTERACTION BETWEEN RIBOSOME-BOUND NASCENT PROTEINS AND A SPECIFIC REGION OF THE RIBOSOMAL SURFACE. Valeria Guzman Luna , AndrewM. Fuchs, Rayna M. Addabbo, Anna J. Allen, Silvia Cavagnero 955-Pos B oard B5 PROBING THE ROLE OF CHAIN CONNECTIVITY IN THE CO-TRANSLATION- AL FOLDING PROCESS OF HALOTAG THROUGH CIRCULAR PERMUTA- TION. Natalie R. Dall , Susan Marqusee 956-Pos B oard B6 DETAIL DYNAMICS AFTER ATP BINDING IN HSP90 CHAPERONE CYCLE AND THE EFFECT OF NOVEL PEPTIDE DRUG CANDIDATE USING MOLECULAR DYNAMICS SIMULATIONS. Lisa Matsukura , Naoyuki Miyashita 957-Pos B oard B7 SPATIAL RELATIONSHIP BETWEEN MEMBRANE, AAA+ DOMAIN AND BOUND PROTEIN SUBSTRATE DETERMINES THE UNFOLDASE ACTIVITY OF THE MEMBRANE-INTEGRATED AAA+ PROTEASE FTSH. Mihiravi Gunasekara , Heedeok Hong 958-Pos B oard B8 DOMAIN INTERACTIONS DETERMINE THE CONFORMATIONAL ENSEMBLE OF THE PERIPLASMIC CHAPERONE SURA. Mathis J. Leblanc , Dagan C. Marx, Ashlee M. Plummer, Susan Krueger, Karen G. Fleming 959-Pos B oard B9 THE HSP70 CHAPERONE IS MOST EFFICIENT AT CIRCUMVENTING AG- GREGATION IF CLIENT PROTEINS FOLD BEFORE THEIR RELEASE IN SOLU- TION. Miranda Mecha , Jasmine Machhi, Silvia Cavagnero 960-Pos B oard B10 OPTIMAL PREVENTION OF CLIENT-PROTEIN AGGREGATION ON THE SUR- FACE OF THE HSP70 CHAPERONE: A COMPUTATIONAL STUDY. Jasmine Machhi , Miranda Mecha, Silvia Cavagnero 961-Pos B oard B11 MOLECULAR DETAILS OF PROTEIN MISFOLDING IN MYOCILIN-ASSOCIAT- ED GLAUCOMA. Raquel L. Lieberman 962-Pos B oard B12 NEGATIVE INTERDOMAIN COUPLING OF DYSTROPHIN SPECTRIN REPEATS. Kari S. Olson , Althea Amaris, Adeesha Jayathilaka, Jonathan Tigner, John Shortreed, Michael Fealey, Anne Hinderliter 963-Pos B oard B13 ROLE OF SALT BRIDGES IN UBIQUITIN IN MODULATING THERMODYNAM- IC, KINETIC AND MECHANICAL STABILITIES. Tathagata Nandi , Sri Rama Koti Ainavarapu

964-Pos B oard B14 PROBING FOLDING BARRIERS IN HIGH THROUGHPUT USING PROTEOLY- SIS AND YEAST DISPLAY. Miriam R. Hood , Eva Gerber, Susan Marqusee 965-Pos B oard B15 SELECTION ORIGINATING FROM PROTEIN STABILITY AND FOLDABILITY: RELATIONSHIPS BETWEEN FOLDING FREE ENERGY, SEQUENCE ENSEM- BLE, AND FITNESS. Sanzo Miyazawa 966-Pos B oard B16 CHARACTERIZATION OF CAMKIIALPHA HOLOENZYME STABILITY. Ana P. Torres-Ocampo , Can Özden, Alexandra Hommer, Anne Gardella, Emily Lapinskas, Alfred Samkutty, Edward Esposito, Scott C. Garman, Margaret B oard B17 AN INVESTIGATION OF THE DISULFIDE BRIDGE FORMATION OF A THY- LAKOID PROTEASE USING NANOSECOND-LEVEL MD SIMULATIONS. Alaa El-Khouly , Adithya Polasa, Vivek Govind Kumar, Mahmoud Moradi 968-Pos B oard B18 IDENTIFYING HOTSPOTS IN BINDING OF SARS-COV-2 SPIKE GLYCOPRO- TEIN AND HUMAN ACE2. Jenny Mendis , Ekrem Kaya, Tugba G. Kucukkal 969-Pos B oard B19 MODELLING PH DEPENDENCE OF THE INTERACTION OF ALPHA-B CRYS- TALLIN WITH CLIENT PROTEINS. Yusrah B. Kaudeer, Esi Obeng, Patricia B. O’Hara 970-Pos B oard B20 EFFECT OF THE ANTI-SICKLE CELL DRUG GBT440 (VOXELOTOR) ON MET- HEMOLOBIN. Aldo J. Munoz , Melanie J. Cocco 971-Pos B oard B21 NON-CLASSICAL PROTEIN KINASE A ACTIVATION BY AGGREGATION OF THE PKA R-SUBUNITS AS A MECHANISM OF INHERITED CARNEY COM- PLEX MUTATIONS. Naeimeh Jafari , Jason Delrio, Madoka Akimoto, Olivia Byun, Stephen Boulton, Kody Moleschi, Yousif Sayyed, Pascale Swanson, Jinfeng Huang, Chi Lee, Jian Wu, Susan S. Taylor, Giuseppe Melacini 972-Pos B oard B22 GENERATION OF ENHANCED RIBOSOMES FOR OPTIMAL PROTEIN OVEREXPRESSION VIA CRISPR-CAS9-ASSISTED RECOMBINEERING. Anna J. Allen , Valeria Guzman Luna, Hunter J. Furley, Silvia Cavagnero 973-Pos B oard B23 MOLECULAR DYNAMICS MODELING OF SURFACTANT BLOCK COPOLYMER CATALYSIS OF PROTEIN DISAGGREGATION AND REFOLDING. Kyle McCollum , Michelle Ling, Raphael C. Lee 974-Pos B oard B24 DUAL MECHANISM OF IONIC LIQUID-INDUCED PROTEIN UNFOLD- ING. Pei-Yin Lee , Onkar Singh, Harry Bermudez, Silvina Matysiak 975-Pos B oard B25 INTERPRETING SMFRET-BASED CALCULATION OF TRANSITION PATH TIME WITH MOLECULAR SIMULATIONS. Grace H. Taumoefolau , Robert B. Best 976-Pos B oard B26 GENERALIZATION OF THE GIBBS-THOMSON EQUATION AND PREDICT- ING MELTING TEMPERATURES OF BIOMACROMOLECULES IN CONFINED GEOMETRIES. David V. Svintradze 977-Pos B oard B27 CRYO-EM STRUCTURE OF AN ACTIVE TETRADECAMERIC AAA+ CHAP- ERONE CLPL. Gyuhee Kim , Seong-Gyu Lee, Seungsu Han, Jaeeun Jung, Hyeong Seop Jeong, Jae-kyung Hyun, Dong-Kwon Rhee, Ho Min Kim, Sangho Lee Stratton 967-Pos

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